Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients

  • Authors:
    • Hiroyuki Shoji
    • Hajime Isomoto
    • Akira Yoshida
    • Haruo Ikeda
    • Hitomi Minami
    • Tsutomu Kanda
    • Shigetoshi Urabe
    • Kayoko Matsushima
    • Fuminao Takeshima
    • Kazuhiko Nakao
    • Haruhiro Inoue
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852‑8501, Japan, Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224‑8503, Japan
    Copyright: © Shoji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 898-904
    |
    Published online on: June 13, 2017
       https://doi.org/10.3892/etm.2017.4598
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Esophageal achalasia is considered as a risk factor of esophageal cancer. The etiologies of esophageal achalasia remain unknown. Peroral endoscopic myotomy (POEM) has recently been established as a minimally invasive method with high curability. The aims of the present study were to identify the microRNAs (miRs) specific to esophageal achalasia, to determine their potential target genes and to assess their alteration following POEM. RNA was extracted from biopsy samples from middle esophageal mucosa and analyzed using a microarray. Differentially expressed miRs in achalasia patients compared with control samples were identified and analyzed using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Correlations between specific miR expression levels and the patients' clinical background were also investigated. In addition, alterations of selected miR expression levels before and after POEM were analyzed. The results of RT‑qPCR analysis demonstrated that the miR‑130a expression levels were significantly higher in patients with achalasia (P<0.0001). In addition, miR‑130a expression was significantly correlated with male sex and smoking history in patients with achalasia. However, no significant change in miR‑130a expression was observed between before and after POEM. In conclusion, miR‑130a is highly expressed in the esophageal mucosa of patients with achalasia and may be a biomarker of esophageal achalasia.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Leeuwenburgh I, Scholten P, Alderliesten J, Tilanus HW, Looman CW, Steijerberg EW and Kuipers EJ: Long-term esophageal cancer risk in patients with primary achalasia: A prospective study. Am J Gastroenterol. 105:2144–2149. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Gockel I, Muller M and Schumacher J: Achalasia-a disease of unknown cause that is often diagnosed too late. Dtsch Arztebl Int. 109:209–214. 2012.PubMed/NCBI

3 

Zendehdel K, Nyrén O, Edberg A and Ye W: Risk of esophageal adenocarcinoma in achalasia patients, a retrospective cohort study in Sweden. Am J Gastroenterol. 106:57–61. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Meijssen MA, Tilanus HW, van Blankenstein M, Hop WC and Ong GL: Achalasia complicated by esophageal squamous cell carcinoma: A prospective study in 195 patients. Gut. 33:155–158. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Porschen R, Molsberger G, Kühn A, Sarbia M and Borchard F: Achalasia-associated squamous cell carcinoma of the esophagus: Flow-cytometric and histological evaluation. Gastroenterology. 108:5455491995. View Article : Google Scholar

6 

Streitz JM Jr, Ellis FH Jr, Gibb SP and Heatley GM: Achalasia and squamous cell carcinoma of the esophagus: Analysis of 241 patients. Ann Thorac Surg. 59:1604–1609. 1995. View Article : Google Scholar : PubMed/NCBI

7 

West RL, Hirsch DP, Bartelsman JF, de Borst J, Ferwerda G, Tytqat GN and Boeckxstaens GE: Long term results of pneumatic dilation in achalasia followed for more than 5 years. Am J Gastroenterol. 97:1346–1351. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Minami H, Yamaguchi N, Matsushima K, Akazawa Y, Ohnita K, Takeshima F, Nakayama T, Hayashi T, Inoue H, Nakao K and Isomoto H: Improvement of endocytoscopic findings after per oral endoscopic myotomy POEM) in esophageal achalasia; does POEM reduce the risk of developing esophageal carcinoma? Per oral endoscopic myotomy, endocytoscopy and carcinogenesis. BMC Gastroenterol. 13:222013. View Article : Google Scholar : PubMed/NCBI

9 

Campos GM, Vittinqhoff E, Rabl C, Takata M, Gadenstätter M, Lin F and Ciovica R: Endoscopic and surgical treatments for achalasia: A systematic review and meta-analysis. Ann Surg. 249:45–57. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Inoue H, Minami H, Kobayashi Y, Sato Y, Kaga M, Suzuki M, Satodate H, Okada N, Itoh H and Kudo S: Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 42:265–271. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Minami H, Isomoto H, Yamaguchi N, Matsushima K, Akazawa Y, Ohnita K, Takeshima F, Inoue H and Nakao K: Peroral endoscopic myotomy for esophageal achalasia: Clinical impact of 28 cases. Dig Endosc. 26:43–51. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Matsushima K, Isomoto H, Yamaguchi N, Inoue N, Machida H, Nakayama T, Hayashi T, Kunizaki M, Hidaka S, Nagayasu T, et al: MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. J Transl Med. 9:302011. View Article : Google Scholar : PubMed/NCBI

13 

Carthew RW and Sontheimer EJ: Origins and Mechanisms of miRNAs and siRNAs. Cell. 136:642–655. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Schmittgen TD: Regulation of microRNA processing in development, differentiation and cancer. J Cell Mol Med. 12:1811–1819. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Rosenfeld N, Aharonov R, Meiri E, Rosenwald S, Spector Y, Zepeniuk M, Benjamin H, Shabes N, Tabak S, Levy A, et al: MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol. 26:462–469. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Liang Y, Ridzon D, Wong L and Chen C: Characterization of microRNA expression profiles in normal human tissues. BMC Genomics. 8:1662007. View Article : Google Scholar : PubMed/NCBI

17 

Croce CM: Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 10:704–714. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Mathé EA, Nguyen GH, Bowman ED, Zhao Y, Budhu A, Schetter AJ, Braun R, Reimers M, Kumamoto K, Hughes D, et al: MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: Associations with survival. Clin Cancer Res. 15:6192–6200. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Feber A, Xi L, Luketich JD, Pennathur A, Landreneau RJ, Wu M, Swanson SJ, Godfrey TE and Litle VR: MicroRNA expression profiles of esophageal cancer. J Thorac Cardiovasc Surg. 135:255–260. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Lebanony D, Benjamin H, Gilad S, Ezagouri M, Dov A, Ashkenazi K, Gefen N, Izraeli S, Rechavi G, Pass H, et al: Diagnostic assay based on I-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J Clin Oncol. 27:2030–2037. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K and Itoh H: Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC. Oncol Rep. 23:1625–1633. 2010.PubMed/NCBI

22 

Smith CM, Michael MZ, Watson DI, Tan G, Astill DS, Hummel R and Hussey DJ: Impact of gastro-oesophageal reflux on microRNA expression, location and function. BMC Gastroenterol. 13:42013. View Article : Google Scholar : PubMed/NCBI

23 

Leeuwenburgh I, Haringsma J, Van Dekken H, Scholten P, Siersema PD and Kuipers EJ: Long-term risk of oesophagitis, Barrett's oesophagus and oesophageal cancer in achalasia patients. Scand J Gastroenterol. Suppl 7–10:2006. View Article : Google Scholar

24 

Descriptive Rules for Achalasia of the Esophagus. 4th. Japan Society of Esophageal Diseases, Kanehara & Co., Ltd.; Tokyo: 2012

25 

Matsui N, Akahoshi K, Nakamura K, Ihara E and Kita H: Endoscopic submucosal dissection for removal of superficial gastrointestinal neoplasms: A technical review. World J Gastrointest Endosc. 4:123–136. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Gibcus JH, Menkema L, Mastik MF, Hermsen MA, de Bock GH, van Velthuysen ML, Takes RP, Kok K, Marcos CA Alvarez, van der Laan BF, et al: Amplicon mapping and expression profiling identify the Fas-associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer. Clin Cancer Res. 13:6257–6266. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Reshmi SC, Huang X, Schoppy DW, Black RC, Saunders WS, Smith DI and Gollin SM: Relationship between FRA11F and 11q13 gene amplification in oral cancer. Genes Chromosomes Cancer. 46:143–54. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Cheng CK, Chow LW, Loo WT, Chan TK and Chan V: The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer. Cancer Res. 65:8646–8654. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Zheng SL, Stevens VL, Wiklund F, Isaacs SD, Sun J, Smith S, Pruett K, Wiley KE, Kim ST, Zhu Y, et al: Two independent prostate cancer risk-associated Loci at 11q13. Cancer Epidemiol Biomarkers Prev. 18:1815–1820. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Chen Y and Gorski DH: Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Blood. 111:1217–1226. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Boll K, Reiche K, Kasack K, Mörbt N, Kretzschmar AK, Tomm JM, Verhaegh G, Schalken J, von Bergen M, Horn F and Hackermüller J: MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma. Oncogene. 32:277–285. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Xu N, Shen C, Luo Y, Xia L, Xue F, Xia Q and Zhang J: Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell. Biochem Biophys Res Commun. 425:468–272. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Yang L, Li N, Wang H, Jia X, Wang X and Luo J: Altered microRNA expression in cisplatin-resistant ovarian cancer cells and upregulation of miR-130a associated with MDR1/P-glycoprotein-mediated drug resistance. Oncol Rep. 28:592–600. 2012.PubMed/NCBI

34 

Acunzo M, Visone R, Romano G, Veronese A, Lovat F, Palmieri D, Bottoni A, Garofalo M, Gasparini P, Condorelli G, et al: miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222. Oncogene. 31:634–642. 2012.PubMed/NCBI

35 

Shi B, Gao H, Zhang T and Cui Q: Analysis of plasma microRNA expression profiles revealed different cancer susceptibility in healthy young adult smokers and middle-aged smokers. Oncotarget. 7:21676–21685. 2016.PubMed/NCBI

36 

Mullany LE, Herrick JS, Wolff RK, Stevens JR and Slattery ML: Assosiation of cigarette smoking and microRNA expression in rectal cancer: Insight into tumor phenotype. Cancer Epidemiol. 45:98–107. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Laporte J, Hu LJ, Kretz C, Mandel JL, Kioschis P, Coy JF, Kluack SM, Poustka A and Dahl N: A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast. Nat Genet. 13:175–182. 1996. View Article : Google Scholar : PubMed/NCBI

38 

Senderek J, Bergmann C, Weber S, Ketelsen UP, Schorle H, Rudnik-Shöneborn S, Büttner R, Buchheim E and Zerres K: Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15. Hum Mol Genet. 12:349–356. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shoji H, Isomoto H, Yoshida A, Ikeda H, Minami H, Kanda T, Urabe S, Matsushima K, Takeshima F, Nakao K, Nakao K, et al: MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients. Exp Ther Med 14: 898-904, 2017.
APA
Shoji, H., Isomoto, H., Yoshida, A., Ikeda, H., Minami, H., Kanda, T. ... Inoue, H. (2017). MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients. Experimental and Therapeutic Medicine, 14, 898-904. https://doi.org/10.3892/etm.2017.4598
MLA
Shoji, H., Isomoto, H., Yoshida, A., Ikeda, H., Minami, H., Kanda, T., Urabe, S., Matsushima, K., Takeshima, F., Nakao, K., Inoue, H."MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients". Experimental and Therapeutic Medicine 14.2 (2017): 898-904.
Chicago
Shoji, H., Isomoto, H., Yoshida, A., Ikeda, H., Minami, H., Kanda, T., Urabe, S., Matsushima, K., Takeshima, F., Nakao, K., Inoue, H."MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients". Experimental and Therapeutic Medicine 14, no. 2 (2017): 898-904. https://doi.org/10.3892/etm.2017.4598
Copy and paste a formatted citation
x
Spandidos Publications style
Shoji H, Isomoto H, Yoshida A, Ikeda H, Minami H, Kanda T, Urabe S, Matsushima K, Takeshima F, Nakao K, Nakao K, et al: MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients. Exp Ther Med 14: 898-904, 2017.
APA
Shoji, H., Isomoto, H., Yoshida, A., Ikeda, H., Minami, H., Kanda, T. ... Inoue, H. (2017). MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients. Experimental and Therapeutic Medicine, 14, 898-904. https://doi.org/10.3892/etm.2017.4598
MLA
Shoji, H., Isomoto, H., Yoshida, A., Ikeda, H., Minami, H., Kanda, T., Urabe, S., Matsushima, K., Takeshima, F., Nakao, K., Inoue, H."MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients". Experimental and Therapeutic Medicine 14.2 (2017): 898-904.
Chicago
Shoji, H., Isomoto, H., Yoshida, A., Ikeda, H., Minami, H., Kanda, T., Urabe, S., Matsushima, K., Takeshima, F., Nakao, K., Inoue, H."MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients". Experimental and Therapeutic Medicine 14, no. 2 (2017): 898-904. https://doi.org/10.3892/etm.2017.4598
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team