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Article

Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans

  • Authors:
    • Ying Liang
    • Qinying Cao
    • Xing Gao
    • Huilan Du
  • View Affiliations / Copyright

    Affiliations: Reproductive Medicine Center, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, Hebei 050011, P.R. China, Prenatal Diagnosis Center, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, Hebei 050011, P.R. China, Department of Integrated Traditional and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050091, P.R. China
  • Pages: 1171-1176
    |
    Published online on: June 14, 2017
       https://doi.org/10.3892/etm.2017.4603
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Abstract

Bone morphogenetic protein-6 (BMP-6), which is a member of the transforming growth factor‑β superfamily, is associated with the regulation of bone development and various physiological processes. In the present study, the expression of BMP‑6 in follicular fluid and granulosa cells (GCs) from pregnant and non‑pregnant patients was explored. A total of 44 pregnant patients (pregnant group) and 36 non-pregnant patients (non‑pregnant group) were recruited for the present study. The expression of BMP‑6 was detected using western blotting and reverse transcription‑quantitative polymerase chain reaction. The expression of BMP‑6 was significantly higher at the protein level (P<0.01) in follicular fluid obtained from the pregnant group compared with that from the non‑pregnant group. The mRNA and protein expression of BMP‑6 in GCs were significantly upregulated in the pregnant group compared with the non‑pregnant group (both P<0.01). These results suggest that high expression of BMP‑6 in pregnant women may be a novel biomarker for the fertility process.
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Copy and paste a formatted citation
Spandidos Publications style
Liang Y, Cao Q, Gao X and Du H: Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans. Exp Ther Med 14: 1171-1176, 2017.
APA
Liang, Y., Cao, Q., Gao, X., & Du, H. (2017). Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans. Experimental and Therapeutic Medicine, 14, 1171-1176. https://doi.org/10.3892/etm.2017.4603
MLA
Liang, Y., Cao, Q., Gao, X., Du, H."Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans". Experimental and Therapeutic Medicine 14.2 (2017): 1171-1176.
Chicago
Liang, Y., Cao, Q., Gao, X., Du, H."Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1171-1176. https://doi.org/10.3892/etm.2017.4603
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Cao Q, Gao X and Du H: Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans. Exp Ther Med 14: 1171-1176, 2017.
APA
Liang, Y., Cao, Q., Gao, X., & Du, H. (2017). Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans. Experimental and Therapeutic Medicine, 14, 1171-1176. https://doi.org/10.3892/etm.2017.4603
MLA
Liang, Y., Cao, Q., Gao, X., Du, H."Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans". Experimental and Therapeutic Medicine 14.2 (2017): 1171-1176.
Chicago
Liang, Y., Cao, Q., Gao, X., Du, H."Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1171-1176. https://doi.org/10.3892/etm.2017.4603
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