Protective effect of glycyrrhizin on myocardial ischemia/reperfusion injury‑induced oxidative stress, inducible nitric oxide synthase and inflammatory reactions through high‑mobility group box 1 and mitogen‑activated protein kinase expression

  • Authors:
    • Xiangna Cai
    • Xin Wang
    • Jilin Li
    • Shuying Chen
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  • Published online on: June 15, 2017     https://doi.org/10.3892/etm.2017.4617
  • Pages: 1219-1226
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Abstract

Glycyrrhizin, which is a type of perennial leguminous caudex, has been used in various Asian countries, including P.R. China, India and Japan, for thousands of years. The present study was designed to investigate the protective effect of glycyrrhizin on myocardial ischemia/reperfusion (I/R) injury through oxidative stress, inducible nitric oxide synthase (iNOS), and inflammatory reactions via high‑mobility group box 1 (HMGB1) and mitogen‑activated protein kinase (MAPK) expression. Sprague‑Dawley rats were divided into five groups: Sham; myocardial I/R injury + non‑treated; myocardial I/R injury + 2 mg/kg glycyrrhizin; myocardial I/R injury + 4 mg/kg glycyrrhizin; and myocardial I/R injury + 10 mg/kg glycyrrhizin. Pre‑treatment with glycyrrhizin significantly reduced infarct size and inhibited creatine kinase, creatine kinase‑MB, lactate dehydrogenase and cardiac troponin T activities in rats with myocardial I/R injury. Furthermore, glycyrrhizin treatment significantly suppressed oxidative stress, iNOS protein expression and inflammatory reactions in rats with myocardial I/R injury. Additionally, treatment with glycyrrhizin significantly decreased the release of HMGB1 from the cerebral cortex into the serum in rats with myocardial I/R injury. Notably, glycyrrhizin significantly suppressed p‑ERK, p‑p38 MAPK and p‑c‑Jun N‑terminal kinase protein expressions, and promoted extracellular signal‑regulated kinase protein expression in rats with myocardial I/R injury. Collectively, the present study indicates that the protective effect of glycyrrhizin may reduce myocardial I/R injury through oxidative stress, iNOS and inflammatory reactions, via HMGB1 and MAPK expression.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cai X, Wang X, Li J and Chen S: Protective effect of glycyrrhizin on myocardial ischemia/reperfusion injury‑induced oxidative stress, inducible nitric oxide synthase and inflammatory reactions through high‑mobility group box 1 and mitogen‑activated protein kinase expression. Exp Ther Med 14: 1219-1226, 2017
APA
Cai, X., Wang, X., Li, J., & Chen, S. (2017). Protective effect of glycyrrhizin on myocardial ischemia/reperfusion injury‑induced oxidative stress, inducible nitric oxide synthase and inflammatory reactions through high‑mobility group box 1 and mitogen‑activated protein kinase expression. Experimental and Therapeutic Medicine, 14, 1219-1226. https://doi.org/10.3892/etm.2017.4617
MLA
Cai, X., Wang, X., Li, J., Chen, S."Protective effect of glycyrrhizin on myocardial ischemia/reperfusion injury‑induced oxidative stress, inducible nitric oxide synthase and inflammatory reactions through high‑mobility group box 1 and mitogen‑activated protein kinase expression". Experimental and Therapeutic Medicine 14.2 (2017): 1219-1226.
Chicago
Cai, X., Wang, X., Li, J., Chen, S."Protective effect of glycyrrhizin on myocardial ischemia/reperfusion injury‑induced oxidative stress, inducible nitric oxide synthase and inflammatory reactions through high‑mobility group box 1 and mitogen‑activated protein kinase expression". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1219-1226. https://doi.org/10.3892/etm.2017.4617