Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Hard clam extracts induce atypical apoptosis in human gastric cancer cells

  • Authors:
    • Eing‑Ju Song
    • Michael W.Y. Chan
    • Jyh‑Wei Shin
    • Che‑Chun Chen
  • View Affiliations / Copyright

    Affiliations: Department of Bioscience Technology, Chang Jung Christian University, Tainan 71101, Taiwan R.O.C., Department of Life Science, Institute of Molecular Biology, National Chung Cheng University, Chiayi 62102, Taiwan R.O.C., Department of Parasitology, College of Medical, National Cheng Kung University, Tainan 70403, Taiwan R.O.C., Department of Aquatic Biosciences, National Chiayi University, Chiayi 60004, Taiwan R.O.C.
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1409-1418
    |
    Published online on: June 20, 2017
       https://doi.org/10.3892/etm.2017.4630
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hard clams (HCs) are a nutritionally high‑quality and popular seafood, and are established to be a potent antitumor food. The aim of the present study was to determine whether HC extracts induce apoptosis in the human gastric cancer cell line, AGS. In contrast with previously reported methods of extraction, crude extracts of HC were obtained by freezing and thawing and by a method free of hot water or organic solvents. The composition, quality and properties of the HC extracts were demonstrated to be stable since the extracts that were evaluated by capillary electrophoresis and HPLC analysis at different timepoints were similar. HC extracts also have an inhibitory effect against the survival of AGS cells. Treatment with HC extracts induced a marked sub‑G1 DNA peak and reduced the expression of the anti‑apoptotic genes BIRC5 and KPNA2. However, hallmarks of classical apoptosis such as DNA fragmentation and apoptotic body formation were not observed, indicating atypical apoptosis. Furthermore, it was revealed that HC extracts interrupted cell cycle progression in AGS cells through altered expression of six cell cycle‑associated genes: CDC20, KPNA2, BIRC5, ANAPC2, CDKN1A and RB1. The present findings suggest that HC may contribute to a novel future anticancer agent.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ferruzzi MG and Blakeslee J: Digestion, absorption, and cancer preventative activity of dietary chlorophyll derivatives. Nutr Res. 27:1–12. 2007. View Article : Google Scholar

2 

Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet R and Sigman CC: Chemopreventive drug development: Perspectives and progress. Cancer Epidemiol Biomarkers Prev. 3:85–98. 1994.PubMed/NCBI

3 

Lee HS, Na MH and Kim WK: alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells. Nutr Res. 30:403–409. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Sutandyo N: Nutritional carcinogenesis. Acta Med Indones. 42:36–42. 2010.PubMed/NCBI

5 

Howson CP, Hiyama T and Wynder EL: The decline in gastric cancer: Epidemiology of an unplanned triumph. Epidemiol Rev. 8:1–27. 1986. View Article : Google Scholar : PubMed/NCBI

6 

Suruo T: Mechanisms of multidrug resistance and implications for therapy. Jpn J Cancer Res. 79:285–296. 1988. View Article : Google Scholar : PubMed/NCBI

7 

Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I and Willingham MC: Cellular localization of the multidrug- resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA. 84:pp. 7735–7738. 1987; View Article : Google Scholar : PubMed/NCBI

8 

Woolley PV III, Kumar S, Monks TF and Ortiz JE: Colon cancer as a model for resistance to antineoplastic drugsMechanisms of Drug Resistance in Neoplastic Cells. Woolley PV III and Tew KD: Academic Press Inc.; San Diego, CA: pp. 31988, View Article : Google Scholar

9 

Ikeda Y, Mori M, Adachi Y, Matsushima T, Sugimachi K and Saku M: Carcinoembryonic antigen (CEA) in stage IV gastric cancer as a risk factor for liver metastasis: A univariate and multivariate analysis. J Surg Oncol. 53:235–238. 1993. View Article : Google Scholar : PubMed/NCBI

10 

Song EJ, Yang VC, Chiang CD and Chao CC: Potentiation of growth inhibition due to vincristine by ascorbic acid in a resistant human non-small cell lung cancer cell line. Eur J Pharmacol. 292:119–125. 1995.PubMed/NCBI

11 

Zhang D and Fan D: Multidrug resistance in gastric cancer: Recent research advances and ongoing therapeutic challenges. Expert Rev Anticancer Ther. 7:1369–1378. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Graham S, Haughey B, Marshall J, Brasure J, Zielezny M, Freudenheim J, West D, Nolan J and Wilkinson G: Diet in the epidemiology of gastric cancer. Nutr Cancer. 13:19–34. 1990. View Article : Google Scholar : PubMed/NCBI

13 

Kono S and Hirohata T: Nutrition and stomach cancer. Cancer Causes Control. 7:41–55. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Kelley JR and Duggan JM: Gastric cancer epidemiology and risk factors. J Clin Epidemiol. 56:1–9. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Chijimatsu T, Tatsuguchi I, Oda H and Mochizuki S: A Freshwater clam (Corbicula fluminea) extract reduces cholesterol level and hepatic lipids in normal rats and xenobiotics-induced hypercholesterolemic rats. J Agric Food Chem. 57:3108–3112. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Pan MH, Huang YT, Ho CT, Chang CI, Hsu PC and Sun Pan B: Induction of apoptosis by Meretrix lusoria through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia cells. Life Sci. 79:1140–1152. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Sazimal I and Dangelo GB: The Asian invasive freshwater clam Corbicula fluminea as prey of two native waterbirds in South-Eastern Brazil. Folia Malacol. 21:293–295. 2013. View Article : Google Scholar

19 

Sugita M, Nakae H, Yamamura T, Takamiya Y, Itasaka O and Hori T: The occurrence of glycosphingolipids containing mannose in the sea-water bivalve, Meretrix lusoria (Hamaguri). J Biochem. 98:27–34. 1985. View Article : Google Scholar : PubMed/NCBI

20 

Karnjanapratum S, Benjakul S, Kishimura H and Tsai YH: Chemical compositions and nutritional value of Asian hard clam (Meretrix lusoria) from the coast of Andaman Sea. Food Chem. 141:4138–4145. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Kritchevsky D, Tepper SA, Ditullo NW and Holmes WL: The sterols of seafood. J Food Sci. 32:64–66. 1967. View Article : Google Scholar

22 

Simopoulos AP: Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr. 54:438–463. 1991.PubMed/NCBI

23 

Sinclair AJ, Murphy KJ and Li D: Marine lipids: Overview ‘news insights and lipid composition of Lyprinol’. Allerg Immunol (Paris). 32:261–271. 2000.PubMed/NCBI

24 

Bevans CG and Harris AL: Regulation of connexin channels by pH. Direct action of the protonated form of taurine and other aminosulfonates. J Biol Chem. 274:3711–3719. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Wu HC and Shiau CY: Proximate composition, free amino acids and peptides contents in commercial chicken and other meat essences. J Food Drug Anal. 10:170–177. 2002.

26 

Hayes KC: Taurine requirement in primates. Nutr Rev. 43:65–70. 1985. View Article : Google Scholar : PubMed/NCBI

27 

Iritani N, Fukuda E and Inoguchi K: Effect of feeding the shell fish (Corbicula japonica) on lipid metabolism in the rat. Atherosclerosis. 34:41–47. 1979. View Article : Google Scholar : PubMed/NCBI

28 

Kong ZL, Chiang LC, Fang F, Shinohara K and Pan P: Immune bioactivity in shellfish toward serum-free cultured human cell lines. Biosci Biotechnol Biochem. 61:24–28. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Tsai JS, Chen JL and Pan BS: ACE-inhibitory peptides identified from the muscle protein hydrolysate of hard clam (Meretrix lusoria). Process Biochem. 43:743–747. 2008. View Article : Google Scholar

30 

Wijesekara I and Kim SK: Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: Prospects in the pharmaceutical industry. Mar Drugs. 8:1080–1093. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Martin KR: Targeting apoptosis with dietary bioactive agents. Exp Biol Med (Maywood). 231:117–129. 2006.PubMed/NCBI

32 

Häkkinen SH, Kärenlampi SO, Heinonen IM, Mykkänen HM and Törrönen AR: HPLC method for screening of flavonoids and phenolic acids in berries. J Sci Food Agric. 77:543–551. 1998. View Article : Google Scholar

33 

Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. 65:55–63. 1983. View Article : Google Scholar : PubMed/NCBI

34 

Huang YT, Huang YH, Hour TC, Pan BS, Liu YC and Pan MH: Apoptosis-inducing active components from Corbicula fluminea through activation of caspase-2 and production of reactive oxygen species in human leukemia HL-60 cells. Food Chem Toxicol. 44:1261–1272. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Sun SY, Hail N Jr and Lotan R: Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst. 96:662–672. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Zhang Y, Zhang QH, Wu LJ, Tashiro S, Onodera S and Ikejima T: Atypical apoptosis in L929 cells induced by evodiamine isolated from Evodia rutaecarpa. J Asian Nat Prod Res. 6:19–27. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Ambrosini G, Adida C and Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 3:917–921. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Zaffaroni N, Pennati M, Colella G, Perego P, Supino R, Gatti L, Pilotti S, Zunino F and Daidone MG: Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer. Cell Mol Life Sci. 59:1406–1412. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Pozarowski P, Halicka DH and Darzynkiewicz Z: NF-kappaB inhibitor sesquiterpene parthenolide induces concurrently atypical apoptosis and cell necrosis: Difficulties in identification of dead cells in such cultures. Cytometry A. 54:118–124. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Hart LS, Ornelles D and Koumenis C: The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage. J Biol Chem. 282:6061–6067. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Hamada M, Nishio K, Doe M, Usuki Y and Tanaka T: Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells. FEBS Lett. 514:250–254. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Shiokawa D, Maruta H and Tanuma S: Inhibitors of poly(ADP-ribose) polymerase suppress nuclear fragmentation and apoptotic-body formation during apoptosis in HL-60 cells. FEBS Lett. 413:99–103. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Son M, Kim HK, Kim WB, Yang J and Kim BK: Protective effect of taurine on indomethacin-induced gastric mucosal injury. Adv Exp Med Biol. 403:147–155. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Scioscia KA, Snyderman CH and Wagner R: Altered serum amino acid profiles in head and neck cancer. Nutr Cancer. 30:144–147. 1998. View Article : Google Scholar : PubMed/NCBI

45 

Vecer J, Kvapil M, Sprongl L, Kubátová H, Hoch J, Jech Z and Charvát J: Tissue amino acids in patients with colorectal carcinoma. Vnitr Lek. 44:192–194. 1998.(In Czech). PubMed/NCBI

46 

You JS and Chang KJ: Taurine protects the liver against lipid peroxidation and membrane disintegration during rat hepatocarcinogenesis. Adv Exp Med Biol. 442:105–112. 1998. View Article : Google Scholar : PubMed/NCBI

47 

Klamt F and Shacter E: Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage. J Biol Chem. 280:21346–21352. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Opstad KS, Bell BA, Griffiths JR and Howe FA: Taurine: A potential marker of apoptosis in gliomas. Br J Cancer. 100:789–794. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Xu XF, Cai BL, Guan SM, Li Y, Wu JZ, Wang Y and Liu B: Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Invest New Drugs. 29:637–645. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Decesse JT, Medjkane S, Datto MB and Crémisi CE: RB regulates transcription of the p21/WAF1/CIP1 gene. Oncogene. 20:962–971. 2001. View Article : Google Scholar : PubMed/NCBI

51 

Carreira S, Goodall J, Aksan I, La Rocca SA, Galibert MD, Denat L, Larue L and Goding CR: Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature. 433:764–769. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Cayrol C, Knibiehler M and Ducommun B: p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene. 16:311–320. 1998. View Article : Google Scholar : PubMed/NCBI

53 

Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:805–816. 1993. View Article : Google Scholar : PubMed/NCBI

54 

Padua MB and Hansen PJ: Changes in expression of cell-cycle-related genes in PC-3 prostate cancer cells caused by ovine uterine serpin. J Cell Biochem. 107:1182–1188. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Löhr K, Möritz C, Contente A and Dobbelstein M: p21/CDKN1A mediates negative regulation of transcription by p53. J Biol Chem. 278:32507–32516. 2003. View Article : Google Scholar : PubMed/NCBI

56 

Baker DJ, Dawlaty MM, Galardy P and van Deursen JM: Mitotic regulation of the anaphase-promoting complex. Cell Mol Life Sci. 64:589–600. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Harper JW, Burton JL and Solomon MJ: The anaphase-promoting complex: It's not just for mitosis any more. Genes Dev. 16:2179–2206. 2002. View Article : Google Scholar : PubMed/NCBI

58 

Kidokoro T, Tanikawa C, Furukawa Y, Katagiri T, Nakamura Y and Matsuda K: CDC20, a potential cancer therapeutic target, is negatively regulated by p53. Oncogene. 27:1562–1571. 2008. View Article : Google Scholar : PubMed/NCBI

59 

Heilman DW, Teodoro JG and Green MR: Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies. J Virol. 80:7535–7545. 2006. View Article : Google Scholar : PubMed/NCBI

60 

Mo M, Fleming SB and Mercer AA: Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11. Proc Natl Acad Sci USA. 106:pp. 19527–19532. 2009; View Article : Google Scholar : PubMed/NCBI

61 

Morgan D, Eley L, Sayer J, Strachan T, Yates LM, Craighead AS and Goodship JA: Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. Hum Mol Genet. 11:3345–3350. 2002. View Article : Google Scholar : PubMed/NCBI

62 

Wirth KG, Ricci R, Giménez-Abián JF, Taghybeeglu S, Kudo NR, Jochum W, Vasseur-Cognet M and Nasmyth K: Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev. 18:88–98. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Song EJ, Chan MW, Shin JW and Chen CC: Hard clam extracts induce atypical apoptosis in human gastric cancer cells. Exp Ther Med 14: 1409-1418, 2017.
APA
Song, E., Chan, M.W., Shin, J., & Chen, C. (2017). Hard clam extracts induce atypical apoptosis in human gastric cancer cells. Experimental and Therapeutic Medicine, 14, 1409-1418. https://doi.org/10.3892/etm.2017.4630
MLA
Song, E., Chan, M. W., Shin, J., Chen, C."Hard clam extracts induce atypical apoptosis in human gastric cancer cells". Experimental and Therapeutic Medicine 14.2 (2017): 1409-1418.
Chicago
Song, E., Chan, M. W., Shin, J., Chen, C."Hard clam extracts induce atypical apoptosis in human gastric cancer cells". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1409-1418. https://doi.org/10.3892/etm.2017.4630
Copy and paste a formatted citation
x
Spandidos Publications style
Song EJ, Chan MW, Shin JW and Chen CC: Hard clam extracts induce atypical apoptosis in human gastric cancer cells. Exp Ther Med 14: 1409-1418, 2017.
APA
Song, E., Chan, M.W., Shin, J., & Chen, C. (2017). Hard clam extracts induce atypical apoptosis in human gastric cancer cells. Experimental and Therapeutic Medicine, 14, 1409-1418. https://doi.org/10.3892/etm.2017.4630
MLA
Song, E., Chan, M. W., Shin, J., Chen, C."Hard clam extracts induce atypical apoptosis in human gastric cancer cells". Experimental and Therapeutic Medicine 14.2 (2017): 1409-1418.
Chicago
Song, E., Chan, M. W., Shin, J., Chen, C."Hard clam extracts induce atypical apoptosis in human gastric cancer cells". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1409-1418. https://doi.org/10.3892/etm.2017.4630
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team