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Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis

  • Authors:
    • Yifei Liu
    • Xiufang Yao
    • Qing Zhang
    • Li Qian
    • Jia Feng
    • Tingting Bian
    • Jianguo Zhang
    • Ye Tian
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China, Department of Pathology, The First People's Hospital of Rudong, Nantong, Jiangsu 226401, P.R. China, Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1351-1356
    |
    Published online on: June 20, 2017
       https://doi.org/10.3892/etm.2017.4632
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Abstract

Kruppel‑like factor 8 (KLF8) belongs to the KLF family and has various roles in the regulation of the cell cycle, proliferation and tumor genesis. KLF8 is overexpressed in gastric, ovarian, breast and renal cancer. Additionally, KLF8 may affect invasion and metastasis of tumors. However, whether KLF8 also acts as an ontogeny in lung adenocarcinoma (LAC) remains unknown. The aim of the present study was to determine the association between KLF8 expression and various clinical and pathological parameters. Western blot assays and immune histochemistry analyses revealed that KLF8 level in LAC tissues was higher than that in the normal lung tissues and KLF8 expression was significantly associated with clinical variables (P<0.05). Kaplan‑Meier curves revealed that high expression of KLF8 was related to poor prognosis in patients with LAC. The present study also demonstrated that KLF8 was involved in the progression of lung adenocarcinoma. This data suggested that KLF8 may act as a prognostic factor in lung adenocarcinoma progression.
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1 

Liu Y, Lv L, Xue Q, Wan C, Ni T, Chen B, Liu Y, Zhou Y, Ni R and Mao G: Vacuolar protein sorting 4B, an ATPase protein positively regulates the progression of NSCLC via promoting cell division. Mol Cell Biochem. 381:163–171. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Rivera C, Pecuchet N, Wermert D, Pricopi C, Le Pimpec-Barthes F, Riquet M and Fabre E: Obesity and lung cancer: Incidence and repercussions on epidemiology, pathology and treatments. Rev Pneumol Clin. 71:37–43. 2015.(In French). View Article : Google Scholar : PubMed/NCBI

3 

Xu MM, Mao GX, Liu J, Li JC, Huang H, Liu YF and Liu JH: Low expression of the FoxO4 gene may contribute to the phenomenon of EMT in non-small cell lung cancer. Asian Pac J Cancer Prev. 15:4013–4018. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Evans PM and Liu C: New insights into KLF8-mediated transactivation. Cell Cycle. 9:649–650. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Shi H, Ji Y, Zhang D, Liu Y and Fang P: MiR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells. Biochem Biophys Res Commun. 465:125–130. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Schnell O, Romagna A, Jaehnert I, Albrecht V, Eigenbrod S, Juerchott K, Kretzschmar H, Tonn JC and Schichor C: Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. PLoS One. 7:e304292012. View Article : Google Scholar : PubMed/NCBI

7 

Chen G, Yang W, Jin W, Wang Y, Tao C and Yu Z: Lentivirus-mediated gene silencing of KLF8 reduced the proliferation and invasion of gastric cancer cells. Mol Biol Rep. 39:9809–9815. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Wang X, Urvalek AM, Liu J and Zhao J: Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. J Biol Chem. 283:13934–13942. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Fu WJ, Li JC, Wu XY, Yang ZB, Mo ZN, Huang JW, Xia GW, Ding Q, Liu KD and Zhu HG: Small interference RNA targeting Krüppel-like factor 8 inhibits the renal carcinoma 786–0 cells growth in vitro and in vivo. J Cancer Res Clin Oncol. 136:1255–1265. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Wang X and Zhao J: KLF8 transcription factor participates in oncogenic transformation. Oncogene. 26:456–461. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Schwab U, Stein H, Gerdes J, Lemke H, Kirchner H, Schaadt M and Diehl V: Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells. Nature. 299:65–67. 1982. View Article : Google Scholar : PubMed/NCBI

12 

Leuverink EM, Brennan BA, Crook ML, Doherty DA, Hammond IG, Ruba S and Stewart CJ: Prognostic value of mitotic counts and Ki-67 immunoreactivity in adult-type granulosa cell tumour of the ovary. J Clin Pathol. 61:914–919. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Melling N, Kowitz CM, Simon R, Bokemeyer C, Terracciano L, Sauter G, Izbicki JR and Marx AH: High Ki67 expression is an independent good prognostic marker in colorectal cancer. J Clin Pathol. 69:209–214. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Sabattini E, Bisgaard K, Ascani S, Poggi S, Piccioli M, Ceccarelli C, Pieri F, Fraternali-Orcioni G and Pileri SA: The EnVision++ system: A new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP ChemMate, CSA, LABC, and SABC techniques. J Clin Pathol. 51:506–511. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Rodriguez E and Martignetti JA: The Kruppel traffic report: Cooperative signals direct KLF8 nuclear transport. Cell Res. 19:1041–1043. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Lahiri SK and Zhao J: Krüppel-like factor 8 emerges as an important regulator of cancer. Am J Transl Res. 4:357–363. 2012.PubMed/NCBI

18 

Eaton SA, Funnell AP, Sue N, Nicholas H, Pearson RC and Crossley M: A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo. J Biol Chem. 283:26937–26947. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF and Villard L: Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. J Med Genet. 39:113–117. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Lee H, Kim HJ, Lee YJ, Lee MY, Choi H, Lee H and Kim JW: Krüppel-like factor KLF8 plays a critical role in adipocyte differentiation. PLoS One. 7:e524742012. View Article : Google Scholar : PubMed/NCBI

21 

van Vliet J, Turner J and Crossley M: Human Krüppel-like factor 8: A CACCC-box binding protein that associates with CtBP and represses transcription. Nucleic Acids Res. 28:1955–1962. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Wei H, Wang X, Gan B, Urvalek AM, Melkoumian ZK, Guan JL and Zhao J: Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. J Biol Chem. 281:16664–16671. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Urvalek AM, Lu H, Wang X, Li T, Yu L, Zhu J, Lin Q and Zhao J: Regulation of the oncoprotein KLF8 by a switch between acetylation and sumoylation. Am J Transl Res. 3:121–132. 2011.PubMed/NCBI

24 

Wang X, Lu H, Urvalek AM, Li T, Yu L, Lamar J, DiPersio CM, Feustel PJ and Zhao J: KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9. Oncogene. 30:1901–1911. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Lu H, Hu L, Yu L, Wang X, Urvalek AM, Li T, Shen C, Mukherjee D, Lahiri SK, Wason MS and Zhao J: KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. Oncogene. 33:2909–2917. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Lu H, Wang X, Urvalek AM, Li T, Xie H, Yu L and Zhao J: Transformation of human ovarian surface epithelial cells by Krüppel-like factor 8. Oncogene. 33:10–18. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Liang K, Liu T, Chu N, Kang J, Zhang R, Yu Y, Li D and Lu D: KLF8 is required for bladder cancer cell proliferation and migration. Biotechnol Appl Biochem. 62:628–633. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Zhang H, Liu L, Wang Y, Zhao G, Xie R, Liu C, Xiao X, Wu K, Nie Y, Zhang H and Fan D: KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells. J Cancer Res Clin Oncol. 139:1033–1042. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Hsu LS, Wu PR, Yeh KT, Yeh CM, Shen KH, Chen CJ and Soon MS: Positive nuclear expression of KLF8 might be correlated with shorter survival in gastric adenocarcinoma. Ann Diagn Pathol. 18:74–77. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Zhao J, Bian ZC, Yee K, Chen BP, Chien S and Guan JL: Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell. 11:1503–1515. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Yao X, Zhang Q, Qian L, Feng J, Bian T, Zhang J and Tian Y: Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis. Exp Ther Med 14: 1351-1356, 2017.
APA
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T. ... Tian, Y. (2017). Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis. Experimental and Therapeutic Medicine, 14, 1351-1356. https://doi.org/10.3892/etm.2017.4632
MLA
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T., Zhang, J., Tian, Y."Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis". Experimental and Therapeutic Medicine 14.2 (2017): 1351-1356.
Chicago
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T., Zhang, J., Tian, Y."Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1351-1356. https://doi.org/10.3892/etm.2017.4632
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Yao X, Zhang Q, Qian L, Feng J, Bian T, Zhang J and Tian Y: Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis. Exp Ther Med 14: 1351-1356, 2017.
APA
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T. ... Tian, Y. (2017). Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis. Experimental and Therapeutic Medicine, 14, 1351-1356. https://doi.org/10.3892/etm.2017.4632
MLA
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T., Zhang, J., Tian, Y."Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis". Experimental and Therapeutic Medicine 14.2 (2017): 1351-1356.
Chicago
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T., Zhang, J., Tian, Y."Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1351-1356. https://doi.org/10.3892/etm.2017.4632
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