Open Access

Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis

  • Authors:
    • Yifei Liu
    • Xiufang Yao
    • Qing Zhang
    • Li Qian
    • Jia Feng
    • Tingting Bian
    • Jianguo Zhang
    • Ye Tian
  • View Affiliations

  • Published online on: June 20, 2017     https://doi.org/10.3892/etm.2017.4632
  • Pages: 1351-1356
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Kruppel‑like factor 8 (KLF8) belongs to the KLF family and has various roles in the regulation of the cell cycle, proliferation and tumor genesis. KLF8 is overexpressed in gastric, ovarian, breast and renal cancer. Additionally, KLF8 may affect invasion and metastasis of tumors. However, whether KLF8 also acts as an ontogeny in lung adenocarcinoma (LAC) remains unknown. The aim of the present study was to determine the association between KLF8 expression and various clinical and pathological parameters. Western blot assays and immune histochemistry analyses revealed that KLF8 level in LAC tissues was higher than that in the normal lung tissues and KLF8 expression was significantly associated with clinical variables (P<0.05). Kaplan‑Meier curves revealed that high expression of KLF8 was related to poor prognosis in patients with LAC. The present study also demonstrated that KLF8 was involved in the progression of lung adenocarcinoma. This data suggested that KLF8 may act as a prognostic factor in lung adenocarcinoma progression.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu Y, Yao X, Zhang Q, Qian L, Feng J, Bian T, Zhang J and Tian Y: Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis. Exp Ther Med 14: 1351-1356, 2017
APA
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T. ... Tian, Y. (2017). Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis. Experimental and Therapeutic Medicine, 14, 1351-1356. https://doi.org/10.3892/etm.2017.4632
MLA
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T., Zhang, J., Tian, Y."Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis". Experimental and Therapeutic Medicine 14.2 (2017): 1351-1356.
Chicago
Liu, Y., Yao, X., Zhang, Q., Qian, L., Feng, J., Bian, T., Zhang, J., Tian, Y."Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1351-1356. https://doi.org/10.3892/etm.2017.4632