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Article

Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells

  • Authors:
    • Qiang Zhang
    • Guangdong Cheng
    • Hongbin Qiu
    • Yuexin Wang
    • Jingtao Wang
    • Hui Xu
    • Tao Zhang
    • Lixin Liu
    • Ye Tao
    • Zhongjuan Ren
  • View Affiliations / Copyright

    Affiliations: Department of Preventive Medicine, School of Public Health, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China, Department of Animal Science, College of Life Science, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China, Department of Biological Chemistry, College of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China, Department of Pharmaceutical Engineering, School of Pharmacological Science, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China
  • Pages: 1795-1801
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    Published online on: June 21, 2017
       https://doi.org/10.3892/etm.2017.4638
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Abstract

Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer cases and may be a potential therapeutic target in the treatment of prostate cancer. The present study evaluated the cytotoxicity of three flavonoids (genistein, luteolin and quercetin) towards DU145 prostate cancer cells, and investigated the effect of these flavonoids on PSCA expression. The results demonstrated that genistein, luteolin and quercetin inhibited the growth of DU145 cells in a dose-dependent manner (P<0.05) and induced morphological changes characteristic of apoptosis in DU145 cells. Flow cytometry analysis also indicated that the flavonoids induced S phase cycle arrest in DU145 cells. Notably, it was observed that expression of PSCA was inhibited at the mRNA (P<0.05) and protein levels in DU145 cells following flavonoid treatment compared with the control. These results suggest that flavonoids may be potential therapeutic agents in the treatment and prevention of prostate cancer.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Quinn M and Babb P: Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: International comparisons. BJU Int. 90:162–173. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Pu YS, Chiang HS, Lin CC, Huang CY, Huang KH and Chen J: Changing trends of prostate cancer in Asia. Aging Male. 7:120–132. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Gu Z, Yamashiro J, Kono E and Reiter RE: Anti-prostate stem cell antigen monoclonal antibody 1G8 induces cell death in vitro and inhibits tumor growth in vivo via a Fc-independent mechanism. Cancer Res. 65:9495–9500. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Barve A, Jin W and Cheng K: Prostate cancer relevant antigens and enzymes for targeted drug delivery. J Control Release. 187:118–132. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Nejatollahi F, Abdi S and Asgharpour M: Antiproliferative and apoptotic effects of a specific antiprostate stem cell single chain antibody on human prostate cancer cells. J Oncol. 2013:8398312013. View Article : Google Scholar : PubMed/NCBI

7 

Antonarakis ES, Carducci MA, Eisenberger MA, Denmeade SR, Slovin SF, Jelaca-Maxwell K, Vincent ME, Scher HI and Morris MJ: Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: A PCCTC trial. Cancer Chemother Pharmacol. 69:763–771. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Saffran DC, Raitano AB, Hubert RS, Witte ON, Reiter RE and Jakobovits A: Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts. Proc Natl Acad Sci USA. 98:pp. 2658–2663. 2001; View Article : Google Scholar : PubMed/NCBI

9 

Kang R, Zhao S, Liu L, Li F, Li E, Luo L, Xu L, Wan S and Zhao Z: Knockdown of PSCA induces EMT and decreases metastatic potentials of the human prostate cancer DU145 cells. Cancer Cell Int. 16:202016. View Article : Google Scholar : PubMed/NCBI

10 

Zhao Z, Ma W, Zeng G, Qi D, Ou L and Liang Y: Small interference RNA-mediated silencing of prostate stem cell antigen attenuates growth, reduces migration and invasion of human prostate cancer PC-3M cells. Urol Oncol. 31:343–351. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Ravishankar D, Rajora AK, Greco F and Osborn HM: Flavonoids as prospective compounds for anti-cancer therapy. Int J Biochem Cell Biol. 45:2821–2831. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Harborne JB and Williams CA: Advances in flavonoid research since 1992. Phytochemistry. 55:481–504. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Ren W, Qiao Z, Wang H, Zhu L and Zhang L: Flavonoids: Promising anticancer agents. Med Res Rev. 23:519–534. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Chiyomaru T, Yamamura S, Fukuhara S, Yoshino H, Kinoshita T, Majid S, Saini S, Chang I, Tanaka Y, Enokida H, et al: Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS One. 8:e703722013. View Article : Google Scholar : PubMed/NCBI

16 

Tsui KH, Chung LC, Feng TH, Chang PL and Juang HH: Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. Int J Cancer. 130:2812–2823. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Tsai PH, Cheng CH, Lin CY, Huang YT, Lee LT, Kandaswami CC, Lin YC, Lee KP, Hung CC, Hwang JJ, et al: Dietary flavonoids luteolin and quercetin suppressed cancer stem cell properties and metastatic potential of isolated prostate cancer cells. Anticancer Res. 36:6367–6380. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Schwartz GK and Shah MA: Targeting the cell cycle: A new approach to cancer therapy. J Clin Oncol. 23:9408–9421. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Lee HZ, Leung HW, Lai MY and Wu CH: Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. Anticancer Res. 25:959–964. 2005.PubMed/NCBI

20 

Shenouda NS, Zhou C, Browning JD, Ansell PJ, Sakla MS, Lubahn DB and Macdonald RS: Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer. 49:200–208. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Knowles LM, Zigrossi DA, Tauber RA, Hightower C and Milner JA: Flavonoids suppress androgen-independent human prostate tumor proliferation. Nutr Cancer. 38:116–122. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Z, Wang CZ, Du GJ, Qi LW, Calway T, He TC, Du W and Yuan CS: Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. Int J Oncol. 43:289–296. 2013.PubMed/NCBI

23 

Markaverich BM, Vijjeswarapu M, Shoulars K and Rodriguez M: Luteolin and gefitinib regulation of EGF signaling pathway and cell cycle pathway genes in PC-3 human prostate cancer cells. J Steroid Biochem Mol Biol. 122:219–231. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Liu KC, Yen CY, Wu RS, Yang JS, Lu HF, Lu KW, Lo C, Chen HY, Tang NY, Wu CC and Chung JG: The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells. Environ Toxicol. 29:428–439. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Neves MP, Cidade H, Pinto M, Silva AM, Gales L, Damas AM, Lima RT, Vasconcelos MH and de São José Nascimento M: Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Eur J Med Chem. 46:2562–2574. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Ahmad N, Adhami VM, Afaq F, Feyes DK and Mukhtar H: Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin Cancer Res. 7:1466–1473. 2001.PubMed/NCBI

27 

Calcabrini A, García-Martínez JM, González L, Tendero MJ, Ortuño MT, Crateri P, Lopez-Rivas A, Arancia G, González-Porqué P and Martín-Pérez J: Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate. Carcinogenesis. 27:1699–1712. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Wang G, Song L, Wang H and Xing N: Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells. Oncol Rep. 30:357–363. 2013.PubMed/NCBI

29 

Zhu QY, Hu R, Liu L, Yuan L, Huang WZ, Ma L and Gu XJ: Quercetin induces the apoptosis of human PC-3 cells. Zhonghua Nan Ke Xue. 17:790–793. 2011.(In Chinese). PubMed/NCBI

30 

Senthilkumar K, Elumalai P, Arunkumar R, Banudevi S, Gunadharini ND, Sharmila G, Selvakumar K and Arunakaran J: Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 344:173–184. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Verma M and Srivastava S: New cancer biomarkers deriving from NCI early detection research. Recent Results Cancer Res. 163:72–84, 264-266. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Kelloff GJ, Bast RC Jr, Coffey DS, D'Amico AV, Kerbel RS, Park JW, Ruddon RW, Rustin GJ, Schilsky RL, Sigman CC and Woude GF Vande: Biomarkers, surrogate end points and the acceleration of drug development for cancer prevention and treatment: An update prologue. Clin Cancer Res. 10:3881–3884. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Collins I and Workman P: New approaches to molecular cancer therapeutics. Nat Chem Biol. 2:689–700. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Kummar S, Gutierrez M, Doroshow JH and Murgo AJ: Drug development in oncology: Classical cytotoxics and molecularly targeted agents. Br J Clin Pharmacol. 62:15–26. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Madu CO and Lu Y: Novel diagnostic biomarkers for prostate cancer. J Cancer. 1:150–177. 2010. View Article : Google Scholar : PubMed/NCBI

36 

White RW deVere, Tsodikov A, Stapp EC, Soares SE, Fujii H and Hackman RM: Effects of a high dose, aglycone-rich soy extract on prostate-specific antigen and serum isoflavone concentrations in men with localized prostate cancer. Nutr Cancer. 62:1036–1043. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Adjakly M, Bosviel R, Rabiau N, Boiteux JP, Bignon YJ, Guy L and Bernard-Gallon D: DNA methylation and soy phytoestrogens: Quantitative study in DU-145 and PC-3 human prostate cancer cell lines. Epigenomics. 3:795–803. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Khan N, Bharali DJ, Adhami VM, Siddiqui IA, Cui H, Shabana SM, Mousa SA and Mukhtar H: Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model. Carcinogenesis. 35:415–423. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Stettner M, Kaulfuss S, Burfeind P, Schweyer S, Strauss A, Ringert RH and Thelen P: The relevance of estrogen receptor-beta expression to the antiproliferative effects observed with histone deacetylase inhibitors and phytoestrogens in prostate cancer treatment. Mol Cancer Ther. 6:2626–2633. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Ross S, Spencer SD, Holcomb I, Tan C, Hongo J, Devaux B, Rangell L, Keller GA, Schow P, Steeves RM, et al: Prostate stem cell antigen as therapy target: Tissue expression and in vivo efficacy of an immunoconjugate. Cancer Res. 62:2546–2553. 2002.PubMed/NCBI

41 

Dannull J, Diener PA, Prikler L, Fürstenberger G, Cerny T, Schmid U, Ackermann DK and Groettrup M: Prostate stem cell antigen is a promising candidate for immunotherapy of advanced prostate cancer. Cancer Res. 60:5522–5528. 2000.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Cheng G, Qiu H, Wang Y, Wang J, Xu H, Zhang T, Liu L, Tao Y, Ren Z, Ren Z, et al: Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells. Exp Ther Med 14: 1795-1801, 2017.
APA
Zhang, Q., Cheng, G., Qiu, H., Wang, Y., Wang, J., Xu, H. ... Ren, Z. (2017). Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells. Experimental and Therapeutic Medicine, 14, 1795-1801. https://doi.org/10.3892/etm.2017.4638
MLA
Zhang, Q., Cheng, G., Qiu, H., Wang, Y., Wang, J., Xu, H., Zhang, T., Liu, L., Tao, Y., Ren, Z."Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells". Experimental and Therapeutic Medicine 14.2 (2017): 1795-1801.
Chicago
Zhang, Q., Cheng, G., Qiu, H., Wang, Y., Wang, J., Xu, H., Zhang, T., Liu, L., Tao, Y., Ren, Z."Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1795-1801. https://doi.org/10.3892/etm.2017.4638
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Cheng G, Qiu H, Wang Y, Wang J, Xu H, Zhang T, Liu L, Tao Y, Ren Z, Ren Z, et al: Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells. Exp Ther Med 14: 1795-1801, 2017.
APA
Zhang, Q., Cheng, G., Qiu, H., Wang, Y., Wang, J., Xu, H. ... Ren, Z. (2017). Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells. Experimental and Therapeutic Medicine, 14, 1795-1801. https://doi.org/10.3892/etm.2017.4638
MLA
Zhang, Q., Cheng, G., Qiu, H., Wang, Y., Wang, J., Xu, H., Zhang, T., Liu, L., Tao, Y., Ren, Z."Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells". Experimental and Therapeutic Medicine 14.2 (2017): 1795-1801.
Chicago
Zhang, Q., Cheng, G., Qiu, H., Wang, Y., Wang, J., Xu, H., Zhang, T., Liu, L., Tao, Y., Ren, Z."Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1795-1801. https://doi.org/10.3892/etm.2017.4638
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