Correlation study between gene and respiratory disease in children

Liu,Huaibin; Min,Jie; Sun,Haomiao; Zhang,Chong-Lin

doi:10.3892/etm.2017.4643

Correlation study between gene and respiratory disease in children

Authors:
- Huaibin Liu
- Jie Min
- Haomiao Sun
- Chong-Lin Zhang
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Affiliations: Department of Internal Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China, Department of Respiration, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China
Published online on: June 22, 2017 https://doi.org/10.3892/etm.2017.4643
Pages: 1463-1466
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The study was designed to explore the correlation between c-Jun N-terminal kinase 1 (JNK1) gene and bronchitis in children with respiratory diseases. From April 2013 to April 2015, 32 cases of children who were admitted to our hospital for bronchitis were selected as the observation group, while 28 cases of normal children in the same period were selected as the control group. The JNK1 gene expression level in the blood of patients of the control and observation groups was detected by quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and western blot analysis. Additionally, the correlation between the levels of JNK1 expression and bronchitis in children was statistically analyzed using SPSS software. JNK1 expression significantly increased in the observation group compared to the control group, and a significant difference was identified (P<0.05). Furthermore, from the detection of JNK1 protein content of blood of child bronchitis with different conditions, we found JNK1 expression gradually increased with the aggravation of bronchitis in children, showing a positive correlation. JNK1 expression was significantly higher in the blood of patients with acute pediatric bronchitis than that of patients with chronic bronchitis. In conclusion, JNK1 promotes the production and deterioration of bronchitis in children, which provides a theoretical and experimental basis for the diagnosis and treatment of children afflicted with bronchitis.

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