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Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation

  • Authors:
    • Bin Chen
    • Han‑Tao Wang
    • Bo Yu
    • Ji‑Dong Zhang
    • Yu Feng
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1614-1620
    |
    Published online on: June 22, 2017
       https://doi.org/10.3892/etm.2017.4645
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Abstract

Carthamin yellow (CY), which is a flavonoid compound isolated from safflower, has various pharmacological effects including promoting blood circulation to remove blood stasis and alleviating pain. CY is a herb used in Chinese traditional medicines. Intervertebral disc degeneration (IDD) is a common spinal disorder and degeneration of nucleus pulposus (NP) cells and inflammation are significant parts of the pathological cascade. The curative effect of CY on NP cells in association with degeneration and inflammation remains to be elucidated. In the present study, rat NP cells were isolated, cultured and used to detect the suppressive effects of CY on lipopolysaccharide (LPS)‑induced genetic expression variation and the expression of matrix degradation enzymes, including matrix metallopeptidase‑3, ADAM metallopeptidase with thrombospondin type 1 motif (ADAMTS)‑4 and ADAMTS‑5. A protective effect of CY on NP cells was observed against LPS‑induced matrix degradation and inflammation. Western blotting results demonstrated that pretreatment with CY significantly suppressed the LPS‑induced activation of the mitogen activated protein kinase (MAPK) pathway. The results of the present study suggested that CY exerted anti‑degenerative and anti‑inflammatory effects on NP cells via inhibition of MAPK pathway activation. Therefore, CY may be a potential therapeutic drug for the treatment of IDD in the future.
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1 

Li Y, Li K, Mao L, Han X, Zhang K, Zhao C and Zhao J: Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc. PeerJ. 4:e19922016. View Article : Google Scholar : PubMed/NCBI

2 

Li Y, Li K, Han X, Mao C, Zhang K, Zhao T and Zhao J: The imbalance between TIMP3 and matrix-degrading enzymes plays an important role in intervertebral disc degeneration. Biochem Biophys Res Commun. 469:507–514. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Campbell RJ, Mobbs RJ and Phan K: Evidence update-association between CILP and degeneration of the intervertebral disc: A meta-analysis. J Spine Surg. 2:242–243. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Ye S, Ju B, Wang H and Lee KB: Bone morphogenetic protein-2 provokes interleukin-18-induced human intervertebral disc degeneration. Bone Joint Res. 5:412–418. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Feng Y, Egan B and Wang J: Genetic factors in intervertebral disc degeneration. Genes Dis. 3:178–185. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Teichtahl AJ, Urquhart DM, Wang Y, Wluka AE, O'Sullivan R, Jones G and Cicuttini FM: Lumbar disc degeneration is associated with modic change and high paraspinal fat content-a 3.0T magnetic resonance imaging study. BMC Musculoskelet Disord. 17:4392016. View Article : Google Scholar : PubMed/NCBI

7 

Hart LG, Deyo RA and Cherkin DC: Physician office visits for low back pain. Frequency, clinical evaluation, and treatment patterns from a U.S. national survey. Spine (Phila Pa 1976). 20:11–19. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Liu MC, Chen WH, Wu LC, Hsu WC, Lo WC, Yeh SD, Wang MF, Zeng R and Deng WP: Establishment of a promising human nucleus pulposus cell line for intervertebral disc tissue engineering. Tissue Eng Part C Methods. 20:1–10. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Szabo G, Hoskin DW, et al: Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 228:1884–1896. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Wang B, Wang D, Yan T and Yuan H: MiR-138-5p promotes TNF-α-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling. Exp Cell Res. 345:199–205. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Liu XG, Hou HW and Liu YL: Expression levels of IL-17 and TNF-α in degenerated lumbar intervertebral discs and their correlation. Exp Ther Med. 11:2333–2340. 2016.PubMed/NCBI

12 

Yang W, Yu XH, Wang C, He WS, Zhang SJ, Yan YG, Zhang J, Xiang YX and Wang WJ: Interleukin-1β in intervertebral disk degeneration. Clin Chim Acta. 450:262–272. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Hu B, Shi C, Xu C, Cao P, Tian Y, Zhang Y, Deng L, Chen H and Yuan W: Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration. Sci Rep. 6:211902016. View Article : Google Scholar : PubMed/NCBI

14 

Fang F and Jiang D: IL-1β/HMGB1 signalling promotes the inflammatory cytokines release via TLR signalling in human intervertebral disc cells. Biosci Rep. 36(pii): e003792016. View Article : Google Scholar : PubMed/NCBI

15 

Li K, Li Y, Ma Z and Zhao J: Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK. Int J Mol Med. 36:1291–1299. 2015.PubMed/NCBI

16 

Zhang Y, Liu L, Wang S, Zhao Y, Liu Y, Li J, Nie L and Cheng L: Production of CCL20 on nucleus pulposus cells recruits IL-17-producing cells to degenerated IVD tissues in rat models. J Mol Histol. 47:81–89. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Karli P, Martlé V, Bossens K, Summerfield A, Doherr MG, Turner P, Vandevelde M, Forterre F and Henke D: Dominance of chemokine ligand 2 and matrix metalloproteinase-2 and −9 and suppression of pro-inflammatory cytokines in the epidural compartment after intervertebral disc extrusion in a canine model. Spine J. 14:2976–2984. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Cheng CY and Lee YC: Anti-inflammatory effects of traditional Chinese medicines against ischemic injury in in vivo models of cerebral ischemia. Evid Based Complement Alternat Med. 2016:57394342016. View Article : Google Scholar : PubMed/NCBI

19 

Zhu F, Yin L, Ji L, Yang F, Zhang G, Shi L and Xu L: Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: An in vivo and in vitro study. Int Immunopharmacol. 30:36–42. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Wang CC, Choy CS, Liu YH, Cheah KP, Li JS, Wang JT, Yu WY, Lin CW, Cheng HW and Hu CM: Protective effect of dried safflower petal aqueous extract and its main constituent, carthamus yellow, against lipopolysaccharide-induced inflammation in RAW264.7 macrophages. J Sci Food Agric. 91:218–225. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Kohno Y, Totsuka K, Ikoma S, Yoda K, Shibata M, Matsushima R, Tomita Y, Maeda Y and Kobayashi K: Photostability enhancement of anionic natural dye by intercalation into hydrotalcite. J Colloid Interface Sci. 337:117–121. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Fan S, Lin N, Shan G, Zuo P and Cui L: Safflower yellow for acute ischemic stroke: A systematic review of randomized controlled trials. Complement Ther Med. 22:354–361. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Zhou MX, Fu JH, Zhang Q and Wang JQ: Effect of hydroxy safflower yellow A on myocardial apoptosis after acute myocardial infarction in rats. Genet Mol Res. 14:3133–3141. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Han XG, Li Y, Mo HM, Li K, Lin D, Zhao CQ, Zhao J and Tang TT: TIMP3 regulates osteosarcoma cell migration, invasion, and chemotherapeutic resistances. Tumour Biol. 37:8857–8867. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Han XG, Du L, Qiao H, Tu B, Wang YG, Qin A, Dai KR, Fan QM and Tang TT: CXCR1 knockdown improves the sensitivity of osteosarcoma to cisplatin. Cancer Lett. 369:405–415. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Li HX, Han SY, Wang XW, Ma X, Zhang K, Wang L, Ma ZZ and Tu PF: Effect of the carthamins yellow from Carthamus tinctorius L. on hemorheological disorders of blood stasis in rats. Food Chem Toxicol. 47:1797–1802. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Vo NV, Hartman RA, Yurube T, Jacobs LJ, Sowa GA and Kang JD: Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. Spine J. 13:331–341. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Weiler C, Nerlich AG, Zipperer J, Bachmeier BE and Boos N: 2002 SSE award competition in basic science: Expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur Spine J. 11:308–320. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Gendron C, Kashiwagi M, Lim NH, Enghild JJ, Thøgersen IB, Hughes C, Caterson B and Nagase H: Proteolytic activities of human ADAMTS-5: Comparative studies with ADAMTS-4. J Biol Chem. 282:18294–18306. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Leckie SK, Bechara BP, Hartman RA, Sowa GA, Woods BI, Coelho JP, Witt WT, Dong QD, Bowman BW, Bell KM, et al: Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model. Spine J. 12:7–20. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Li Y, Li K, Hu Y, Xu B and Zhao J: Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc. Int J Clin Exp Pathol. 8:6203–6213. 2015.PubMed/NCBI

32 

Iwata M, Ochi H, Asou Y, Haro H, Aikawa T, Harada Y, Nezu Y, Yogo T, Tagawa M and Hara Y: Variations in gene and protein expression in canine chondrodystrophic nucleus pulposus cells following long-term three-dimensional culture. PloS One. 8:e631202013. View Article : Google Scholar : PubMed/NCBI

33 

Kang YM, Hong SH, Yang JH, Oh JC, Park JO, Lee BH, Lee SY, Kim HS, Lee HM and Moon SH: Pamidronate down-regulates tumor necrosis factor-alpha induced matrix metalloproteinases expression in human intervertebral disc cells. J Bone Metab. 23:165–173. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Williams LM, Lali F, Willetts K, Balague C, Godessart N, Brennan F, Feldmann M and Foxwell BM: Rac mediates TNF-induced cytokine production via modulation of NF-kappaB. Mol Immunol. 45:2446–2454. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Goldring MB, Otero M, Plumb DA, Dragomir C, Favero M, El Hachem K, Hashimoto K, Roach HI, Olivotto E, Borzì RM and Marcu KB: Roles of inflammatory and anabolic cytokines in cartilage metabolism: Signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater. 21:202–220. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Wang J, Chen H, Cao P, Wu X, Zang F, Shi L, Liang L and Yuan W: Inflammatory cytokines induce caveolin-1/β-catenin signalling in rat nucleus pulposus cell apoptosis through the p38 MAPK pathway. Cell Prolif. 49:362–372. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Pratsinis H, Constantinou V, Pavlakis K, Sapkas G and Kletsas D: Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways. J Orthop Res. 30:958–964. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Wang HT, Yu B, Zhang JD and Feng Y: Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation. Exp Ther Med 14: 1614-1620, 2017.
APA
Chen, B., Wang, H., Yu, B., Zhang, J., & Feng, Y. (2017). Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation. Experimental and Therapeutic Medicine, 14, 1614-1620. https://doi.org/10.3892/etm.2017.4645
MLA
Chen, B., Wang, H., Yu, B., Zhang, J., Feng, Y."Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation". Experimental and Therapeutic Medicine 14.2 (2017): 1614-1620.
Chicago
Chen, B., Wang, H., Yu, B., Zhang, J., Feng, Y."Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1614-1620. https://doi.org/10.3892/etm.2017.4645
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Wang HT, Yu B, Zhang JD and Feng Y: Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation. Exp Ther Med 14: 1614-1620, 2017.
APA
Chen, B., Wang, H., Yu, B., Zhang, J., & Feng, Y. (2017). Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation. Experimental and Therapeutic Medicine, 14, 1614-1620. https://doi.org/10.3892/etm.2017.4645
MLA
Chen, B., Wang, H., Yu, B., Zhang, J., Feng, Y."Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation". Experimental and Therapeutic Medicine 14.2 (2017): 1614-1620.
Chicago
Chen, B., Wang, H., Yu, B., Zhang, J., Feng, Y."Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1614-1620. https://doi.org/10.3892/etm.2017.4645
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