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High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway

  • Authors:
    • Yan‑Hong Zhou
    • Qian‑Feng Han
    • Lan‑Hua Wang
    • Tao Liu
    • Xiao‑Yan Meng
    • Lei Wu
    • Tai Li
    • Yue‑Ru Jiao
    • Heng‑Chen Yao
    • De‑Yong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Liaocheng People's Hospital Affiliated to Shandong University and Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1582-1588
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    Published online on: June 22, 2017
       https://doi.org/10.3892/etm.2017.4653
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Abstract

The present study aimed to determine the effects of high mobility group box 1 protein (HMGB1) on myocardial ischemia reperfusion (I/R) injury in rats following acute myocardial ischemia and investigate the underlying molecular mechanisms of these effects. Male Wistar rats were randomly divided into the following groups (n=10/group): Sham operation; I/R; HMGB50 (50 ng/kg HMGB1 before I/R); HMGB100 (100 ng/kg HMGB1 before I/R); and HMGB200 (200 ng/kg HMGB1 before I/R). Serum cardiac troponin I (cTnI), interleukin (IL)‑6 and tumor necrosis factor (TNF)‑α levels were subsequently measured. Myocardial levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were also determined. Myocardial infarction size (IS) was determined by 2,3,5‑triphenyltetrazolium chloride staining. Myocardial expression of hypoxia inducible factor (HIF)‑1α and phosphorylated p38 mitogen‑activated protein kinase (P‑p38 MAPK) protein was measured using western blotting. The results demonstrated that HMGB1 significantly decreased serum levels of cTnI, IL‑6 and TNF‑α and myocardial IS in I/R rats compared with the sham group (all P<0.05). HMGB1 also significantly decreased and increased myocardial levels of MDA and SOD, respectively (both P<0.05). HMGB1 significantly increased myocardial expression of HIF‑1α and decreased expression of P‑p38 MAPK following I/R (both P<0.05). These effects of HMGB1 occurred in a dose‑ dependent manner. The results of the current study indicate that the cardioprotective effects of intravenous HMGB1 are associated with increased myocardial expression of HIF‑1α via inhibition of P‑p38 MAPK expression, leading to inhibition of the P‑p38 MAPK signaling pathway.
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View References

1 

Eltzschig HK and Eckle T: Ischemia and reperfusion-from mechanism to translation. Nat Med. 17:1391–1401. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Maes C, Carmeliet G and Schipani E: Hypoxia-driven pathways in bone development, regeneration and disease. Nat Rev Rheumatol. 8:358–366. 2012. View Article : Google Scholar : PubMed/NCBI

3 

van de Sluis B, Groot AJ, Vermeulen J, van der Wall E, van Diest PJ, Wijmenga C, Klomp LW and Vooijs M: COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70. PLoS One. 4:e73322009. View Article : Google Scholar : PubMed/NCBI

4 

Yao HC, Liu T, Meng XY, Han QF, Zhang M and Wang LX: Effect of basic fibroblast growth factor on the myocardial expression of hypoxia-inducible factor-1α and vascular endothelial growth factor following acute myocardial infarctio. Heart Lung Circ. 22:946–951. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Li J, Kokkola R, Tabibzadeh S, Yang R, Ochani M, Qiang X, Harris HE, Czura CJ, Wang H, Ulloa L, et al: Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med. 9:37–45. 2003.PubMed/NCBI

6 

Yan XX, Lu L, Peng WH, Wang LJ, Zhang Q, Zhang RY, Chen QJ and Shen WF: Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients. Atherosclerosis. 205:544–548. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Kohno T, Anzai T, Naito K, Miyasho T, Okamoto M, Yokota H, Yamada S, Maekawa Y, Takahashi T, Yoshikawa T, et al: Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling. Cardiovasc Res. 81:565–573. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ and Marshak-Rothstein A: RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity. 43:103–110. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Ding HS and Yang J: High mobility group box-1 and cardiovascular diseases. Saudi Med J. 31:486–489. 2010.PubMed/NCBI

10 

Yao HC, Zhao AP, Han QF, Wu L, Yao DK and Wang LX: Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease. Exp Ther Med. 6:121–124. 2013.PubMed/NCBI

11 

Ulloa L and Messmer D: High-mobility group box 1 (HMGB1) protein: Friend and foe. Cytokine Growth Factor Rev. 17:189–201. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Xu H, Yao Y, Su Z, Yang Y, Kao R, Martin CM and Rui T: Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-&alpha;/JNK. Am J Physiol Heart Circ Physiol. 300:H913–H921. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Ran K, Gong ZX, Yang DL, Chang YT, Duan KM and Ou YW: Effect of morphine preconditioning in the delayed phase on the expression of p38 mitogen-activated protein kinase in a rabbit model of myocardial ischemia-reperfusion injury. Genet Mol Res. 14:6642–6648. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Limana F, Germani A, Zacheo A, Kajstura J, Di Carlo A, Borsellino G, Leoni O, Palumbo R, Battistini L, Rastaldo R, et al: Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ Res. 97:e73–e83. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Limana F, Esposito G, Fasanaro P, Foglio E, Arcelli D, Voellenkle C, Di Carlo A, Avitabile D, Martelli F, Russo M Antonio, et al: Transcriptional profiling of hmgb1-induced myocardial repair identifies a key role for notch signaling. Mol Ther. 21:1841–1851. 2013. View Article : Google Scholar

16 

Abarbanell AM, Hartley JA, Herrmann JL, Weil BR, Wang Y, Manukyan MC, Poynter JA and Meldrum DR: Exogenous high-mobility group box 1 improves myocardial recovery after acute global ischemia/reperfusion injury. Surgery. 149:329–335. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Zhang DY, Zhang AX, Zhou YH, Wang LH and Yao HC: Protection of intravenous HMGB1 on myocardial ischemia reperfusion injury. Int J Cardiol. 184:280–282. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Biscetti F, Ghirlanda G and Flex A: Therapeutic potential of high mobility group box-1 in ischemic injury and tissue regeneration. Curr Vasc Pharmacol. 9:677–681. 2011. View Article : Google Scholar : PubMed/NCBI

19 

National Research Council, . Guide for the Care and Use of Laboratory Animals. 8th. The National Academies Press; Washington, DC: 2011, PubMed/NCBI

20 

Takahashi K, Fukushima S, Yamahara K, Yashiro K, Shintani Y, Coppen SR, Salem HK, Brouilette SW, Yacoub MH and Suzuki K: Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart. Circulation. 118 14 Suppl:S106–S114. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Limana F, Esposito G, D'Arcangelo D, Di Carlo A, Romani S, Melillo G, Mangoni A, Bertolami C, Pompilio G, Germani A and Capogrossi MC: HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3. PLoS One. 6:e198452011. View Article : Google Scholar : PubMed/NCBI

22 

Yao HC, Yang LJ, Han QF, Wang LH, Wu L, Zhang CY, Tian KL and Zhang M: Postconditioning with simvastatin decreases myocardial injury in rats following acute myocardial ischemia. Exp Ther Med. 9:1166–1170. 2015.PubMed/NCBI

23 

Chen M, Huang W, Wang C, Nie H, Li G, Sun T, Yang F, Zhang Y, Shu K, Wang C and Gong Q: High-mobility group box 1 exacerbates CCl4-induced acute liver injury in mice. Clin Immunol. 153:56–63. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Zhou X, Hu X, Xie J, Xu C, Xu W and Jiang H: Exogenous high-mobility group box 1 protein injection improves cardiac function after myocardial infarction: Involvement of Wnt signaling activation. J Biomed Biotechnol. 2012:7438792012. View Article : Google Scholar : PubMed/NCBI

25 

He Y, Zhou X, Zheng X and Jiang X: Exogenous high-mobility group box 1 protein prevents postinfarction adverse myocardial remodeling through TGF-β/Smad signaling pathway. J Cell Biochem. 114:1634–1641. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Khimenko PL, Bagby GJ, Fuseler J and Taylor AE: Tumor necrosis factor-alpha in ischemia and reperfusion injury in rat lungs. J Appl Physiol (1985). 85:2005–2011. 1998.PubMed/NCBI

27 

Zhu J, Liu M, Kennedy RH and Liu SJ: TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes. Cytokine. 34:96–105. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Jahangiri A, Leifert WR, Kind KL and McMurchie EJ: Dietary fish oil alters cardiomyocyte Ca2+ dynamics and antioxidant status. Free Radic Bio Med. 40:1592–1602. 2006. View Article : Google Scholar

29 

Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B and Sadoshima J: Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 100:914–922. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Rapino C, Bianchi G, Di Giulio C, Centurione L, Cacchio M, Antonucci A and Cataldi A: HIF-1alpha cytoplasmic accumulation is associated with cell death in old rat cerebral cortex exposed to intermittent hypoxia. Aging Cell. 4:177–185. 2005. View Article : Google Scholar : PubMed/NCBI

31 

AI-Salam S and Hashmi S: Galectin-1 in early acute myocardial infarction. PLoS One. 9:e869942014. View Article : Google Scholar : PubMed/NCBI

32 

Cai Z, Luo W, Zhan H and Semenza GL: Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proc Natl Acad Sci USA. 110:pp. 17462–17467. 2013; View Article : Google Scholar : PubMed/NCBI

33 

Li Q Fang, Xu H, Sun Y, Hu R and Jiang H: Induction of inducible nitric oxide synthase by isoflurane post-conditioning via hypoxia inducible factor-1α during tolerance against ischemic neuronal injury. Brain Res. 1451:1–9. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Li X, Zhao H, Wu Y, Zhang S, Zhao X, Zhang Y, Wang J, Wang J and Liu H: Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. Acta Biochim Biophys Sin (Shanghai). 46:112–118. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Poynter JA, Manukyan MC, Wang Y, Brewster BD, Herrmann JL, Weil BR, Abarbanell AM and Meldrum DR: Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1α and VEGF production and improves functional recovery after acute ischemia/reperfusion. Surgery. 150:278–283. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA and Semenza GL: Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res. 77:463–470. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Adluri RS, Thirunavukkarasu M, Dunna NR, Zhan L, Oriowo B, Takeda K, Sanchez JA, Otani H, Maulik G, Fong GH and Maulik N: Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice. Antioxid Redox Signal. 15:1789–1797. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Ke Q and Costa M: Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol. 70:1469–1480. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Si J, Wang N, Wang H, Xie J, Yang J, Yi H, Shi Z, Ma J, Wang W, Yang L, et al: HIF-1α signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injury. PLoS One. 9:e1078322014. View Article : Google Scholar : PubMed/NCBI

40 

Oriowo B, Thirunavukkarasu M, Selvaraju V, Adluri RS, Zhan L, Takeda K, Fong GH, Sanchez JA and Maulik N: Targeted gene deletion of prolyl hydroxylase domain protein 3 triggers angiogenesis and preserves cardiac function by stabilizing hypoxia inducible factor 1 alpha following myocardial infarction. Curr Pharm Des. 20:1305–1310. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Ong SG, Lee WH, Theodorou L, Kodo K, Lim SY, Shukla DH, Briston T, Kiriakidis S, Ashcroft M, Davidson SM, et al: HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. Cardiovasc Res. 104:24–36. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Yuan X, Niu HT, Wang PL, Lu J, Zhao H, Liu SH, Zheng QS and Li CG: Cardioprotective effect of licochalcone d against myocardial ischemia/reperfusion injury in langendorff-perfused rat hearts. PLoS One. 10:e01283752015. View Article : Google Scholar : PubMed/NCBI

43 

Kumphune S, Surinkaew S, Chattipakorn SC and Chattipakorn N: Inhibition of p38 MAPK activation protects cardiac mitochondria from ischemia/reperfusion injury. Pharm Biol. 53:1831–1841. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Wang X, Lv H, Gu Y, Wang X, Cao H, Tang Y, Chen H and Huang C: Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9. J Mol Histol. 45:113–120. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou YH, Han QF, Wang LH, Liu T, Meng XY, Wu L, Li T, Jiao YR, Yao HC, Zhang DY, Zhang DY, et al: High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway. Exp Ther Med 14: 1582-1588, 2017.
APA
Zhou, Y., Han, Q., Wang, L., Liu, T., Meng, X., Wu, L. ... Zhang, D. (2017). High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway. Experimental and Therapeutic Medicine, 14, 1582-1588. https://doi.org/10.3892/etm.2017.4653
MLA
Zhou, Y., Han, Q., Wang, L., Liu, T., Meng, X., Wu, L., Li, T., Jiao, Y., Yao, H., Zhang, D."High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway". Experimental and Therapeutic Medicine 14.2 (2017): 1582-1588.
Chicago
Zhou, Y., Han, Q., Wang, L., Liu, T., Meng, X., Wu, L., Li, T., Jiao, Y., Yao, H., Zhang, D."High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1582-1588. https://doi.org/10.3892/etm.2017.4653
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou YH, Han QF, Wang LH, Liu T, Meng XY, Wu L, Li T, Jiao YR, Yao HC, Zhang DY, Zhang DY, et al: High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway. Exp Ther Med 14: 1582-1588, 2017.
APA
Zhou, Y., Han, Q., Wang, L., Liu, T., Meng, X., Wu, L. ... Zhang, D. (2017). High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway. Experimental and Therapeutic Medicine, 14, 1582-1588. https://doi.org/10.3892/etm.2017.4653
MLA
Zhou, Y., Han, Q., Wang, L., Liu, T., Meng, X., Wu, L., Li, T., Jiao, Y., Yao, H., Zhang, D."High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway". Experimental and Therapeutic Medicine 14.2 (2017): 1582-1588.
Chicago
Zhou, Y., Han, Q., Wang, L., Liu, T., Meng, X., Wu, L., Li, T., Jiao, Y., Yao, H., Zhang, D."High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1582-1588. https://doi.org/10.3892/etm.2017.4653
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