A novel antitumor compound nobiliside D isolated from sea cucumber (Holothuria nobilis Selenka)

  • Authors:
    • Jia-Jia Zhang
    • Ke-Qi Zhu
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  • Published online on: June 23, 2017     https://doi.org/10.3892/etm.2017.4656
  • Pages: 1653-1658
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Abstract

An anticancer compound, triterpene glycoside, was isolated from Holothuria nobilis Selenka. Its chemical structure and configuration were determined by two‑dimensional nuclear magnetic resonance spectroscopy and electrospray ionization mass spectrometry. The novel active compound was identified as nobiliside D, with the molecular formula C40H61O17SNa and chemical name 3‑O‑[‑β-D-pyranosyl (1-2)‑4'-O-sulfon-ate-β‑D‑xylopyranosyl]‑alkoxy‑9‑ene‑3β, 12α, 17α, 25β‑4 alcohol. An antitumor test was performed using xCELLigence Real‑Time Cell Analysis. Nobiliside D exhibited inhibitory effects on human leukemic cell line K562, human leukemia cell line U937, human lung cancer cell line A‑549, human cervix carcinoma cell line HeLa, human breast cancer cell line MCF‑7 and human liver carcinoma cell line HepG2. Nobiliside exhibited the greatest inhibitory effect on K562 and MCF‑7 cells with an IC50 of 0.83±0.14 and 0.82±0.11 µg/ml, respectively. When human tumor cell lines K562 and MCF‑7 were treated by nobiliside D (0.5 µg/ml) for 24 h, 45.8% of K562 cells and 58.7% of MCF‑7 cells were apoptotic, whereas only 0.5% of un‑treated control cells were apoptotic. These data indicate the compound should offer potential as a novel drug for the treatment of a range of cancers.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang J and Zhu K: A novel antitumor compound nobiliside D isolated from sea cucumber (Holothuria nobilis Selenka). Exp Ther Med 14: 1653-1658, 2017.
APA
Zhang, J., & Zhu, K. (2017). A novel antitumor compound nobiliside D isolated from sea cucumber (Holothuria nobilis Selenka). Experimental and Therapeutic Medicine, 14, 1653-1658. https://doi.org/10.3892/etm.2017.4656
MLA
Zhang, J., Zhu, K."A novel antitumor compound nobiliside D isolated from sea cucumber (Holothuria nobilis Selenka)". Experimental and Therapeutic Medicine 14.2 (2017): 1653-1658.
Chicago
Zhang, J., Zhu, K."A novel antitumor compound nobiliside D isolated from sea cucumber (Holothuria nobilis Selenka)". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1653-1658. https://doi.org/10.3892/etm.2017.4656