Open Access

Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats

  • Authors:
    • Xiaobo Li
    • Min Ma
    • Xianggui Zhang
    • Liang Deng
    • Yarong Wang
    • Zhuang Bian
    • Shining Cai
    • Bangya Peng
    • Jiangquan Yang
    • Yang Chen
  • View Affiliations

  • Published online on: June 23, 2017     https://doi.org/10.3892/etm.2017.4662
  • Pages: 1381-1388
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gardenia fruit has been used in traditional Chinese medicine for thousands of years. A previous study by the present authors indicated that the ethanol extract of gardenia fruits (EEG) primarily contains eight constituents. In the present study, the potential effects of EEG on unilateral ureteral obstruction (UUO)‑induced renal interstitial fibrosis were observed in rats. A total of 30 rats were randomly divided into three groups (n=10 each): Sham group, UUO group, and EEG group, which were administered with EEG (200 mg/kg/day) or the same volume of distilled water as a vehicle. UUO were established by ligating left ureter at two points and cut between the ligatures. All rats were sacrificed at 14 days after UUO operation. the present results demonstrated that EEG significantly elevated the expressions of vascular endothelial growth factor and E‑cadherin induced by UUO (both P<0.05), and reduced levels of hypoxia‑inducible factor‑1α, transforming growth factor‑β1, connective tissue growth factor and α‑smooth muscle actin (all P<0.05). The present findings suggest that EEG is a potential novel renoprotective compound for renal fibrosis through inhibiting epithelial‑to‑mesenchymal transition.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li X, Ma M, Zhang X, Deng L, Wang Y, Bian Z, Cai S, Peng B, Yang J, Chen Y, Chen Y, et al: Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats. Exp Ther Med 14: 1381-1388, 2017
APA
Li, X., Ma, M., Zhang, X., Deng, L., Wang, Y., Bian, Z. ... Chen, Y. (2017). Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats. Experimental and Therapeutic Medicine, 14, 1381-1388. https://doi.org/10.3892/etm.2017.4662
MLA
Li, X., Ma, M., Zhang, X., Deng, L., Wang, Y., Bian, Z., Cai, S., Peng, B., Yang, J., Chen, Y."Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats". Experimental and Therapeutic Medicine 14.2 (2017): 1381-1388.
Chicago
Li, X., Ma, M., Zhang, X., Deng, L., Wang, Y., Bian, Z., Cai, S., Peng, B., Yang, J., Chen, Y."Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1381-1388. https://doi.org/10.3892/etm.2017.4662