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Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis

  • Authors:
    • Jing‑Xiu Li
    • En‑Ze Jin
    • Long‑Hao Yu
    • Yang Li
    • Nan‑Nan Liu
    • Yu‑Mei Dong
    • Xin Li
    • Xue‑Qi Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1568-1576
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    Published online on: June 27, 2017
       https://doi.org/10.3892/etm.2017.4678
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Abstract

It is acknowledged that contrast‑induced nephropathy (CIN) is a common cause of acute renal insufficiency after cardiac catheterization and affects mortality and morbidity. To date, it is unknown whether oral N‑acetylcysteine (NAC) is able to prevent contrast‑induced nephropathy (CIN) in patients undergoing coronary angioplasty. A meta‑analysis of randomized controlled trials was performed to assess the effects of NAC in the prevention of CIN in patients following coronary angioplasty. A total of 19 studies published prior to January 2015 that investigated the efficacy of oral NAC for the prevention of CIN were collected from Medline, Cochrane and Embase databases and conference proceedings from cardiology and nephrology meetings. The primary point of investigation was CIN, and the secondary points were renal failure requiring dialysis, mortality and length of hospitalization. The meta‑analysis was performed using fixed‑ or random‑effect models according to heterogeneity. Up to January 2015, 19 randomized placebo‑controlled clinical trials met the inclusion criteria for the meta‑analysis, including 4,514 patients. The pooled data showed that oral NAC did not reduce the CIN incidence [relative risk 0.84, 95% confidence interval (CI) 0.65‑1.10; P=0.20], without heterogeneity among trials (I2=29%). Thus, the present meta‑analysis suggests that oral NAC therapy is not effective as an alternative treatment to prevent CIN in patients following angioplasty. Further high quality randomized clinical controlled trials are required to confirm the usage and availability of this treatment.
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1 

Tepel M, Aspelin P and Lameire N: Contrast-induced nephropathy: A clinical and evidence-based approach. Circulation. 113:1799–1806. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Thomsen HS: European Society of Urogenital Radiology (ESUR) guidelines on the safe use of iodinated contrast media. Eur J Radiol. 60:307–313. 2006. View Article : Google Scholar : PubMed/NCBI

3 

McCullough PA, Wolyn R, Rocher LL, Levin RN and O'Neill WW: Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality. Am J Med. 103:368–375. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Rihal CS, Textor SC, Grill DE, Berger PB, Ting HH, Best PJ, Singh M, Bell MR, Barsness GW, Mathew V, et al: Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation. 105:2259–2264. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Nikolsky E, Mehran R, Turcot D, Aymong ED, Mintz GS, Lasic Z, Lansky AJ, Tsounias E, Moses JW, Stone GW, et al: Impact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention. Am J Cardiol. 94:300–305. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Bartholomew BA, Harjai KJ, Dukkipati S, Boura JA, Yerkey MW, Glazier S, Grines CL and O'Neill WW: Impact of nephropathy after percutaneous coronary intervention and a method for risk stratification. Am J Cardiol. 93:1515–1519. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz GS, Lansky AJ, Moses JW, Stone GW, et al: A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: Development and initial validation. J Am Coll Cardiol. 44:1393–1399. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Parfrey PS, Griffiths SM, Barrett BJ, Paul MD, Genge M, Withers J, Farid N and McManamon PJ: Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. A prospective controlled study. N Eng J Med. 320:143–149. 1989. View Article : Google Scholar

9 

Rudnick MR and Goldfarb S: Pathogenesis of contrast-induced nephropathy: Experimental and clinical observations with an emphasis on the role of osmolality. Rev Cardiovasc Med. 4 Suppl 5:S28–S33. 2003.PubMed/NCBI

10 

Murphy SW, Barrett BJ and Parfrey PS: Contrast nephropathy. J Am Soc Nephrol. 11:177–182. 2000.PubMed/NCBI

11 

Wright RS, Anderson JL, Adams CD, Bridges CR, Casey DE Jr, Ettinger SM, Fesmire FM, Ganiats TG, Jneid H, Lincoff AM, et al: 2011 ACCF/AHA focused update of the Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction (Updating the 2007 Guideline): A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in collaboration with the American College of Emergency Physicians, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 59:1920–1959. 2011. View Article : Google Scholar

12 

Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D and Zidek W: Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med. 343:180–184. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Shalansky SJ, Vu T, Pate GE, Levin A, Humphries KH and Webb JG: N-acetylcysteine for prevention of radiographic contrast material-induced nephropathy: Is the intravenous route best? Pharmacotherapy. 25:1095–1103. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Karimzadeh I, Khalili H, Sagheb MM and Farsaei S: A double-blinded, placebo-controlled, multicenter clinical trial of N-acetylcysteine for preventing amphotericin B-induced nephrotoxicity. Expert Opin Drug Metab Toxicol. 11:1345–1355. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Baker CS, Wragg A, Kumar S, De Palma R, Baker LR and Knight CJ: A rapid protocol for the prevention of contrast induced renal dysfunction: The RAPPID study. J Am Coll Cardiol. 41:2114–2118. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Ochoa A, Pellizzon G, Addala S, Grines C, Isayenko Y, Boura J, Rempinski D, O'Neill W and Kahn J: Abbreviated dosing of N-acetylcysteine prevents contrast-induced nephropathy after elective and urgent coronary angiography and intervention. J Interv Cardiol. 17:159–165. 2004. View Article : Google Scholar : PubMed/NCBI

17 

MacNeill BD, Harding SA, Bazaril H, Patton KK, Colon-Hernadez P, DeJoseph D and Jang IK: Prophylaxis of contrast-induced nephropathy in patients undergoing coronary angiography. Catheter Cardiovasc Interv. 60:458–461. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Briguori C, Manganelli F, Scarpato P, Elia PP, Golia B, Riviezzo G, Lepore S, Librera M, Villari B, Colombo A and Ricciardelli B: Acetylcysteine and contrast agent associated nephrotoxicity. J Am Coll Cardiol. 40:298–303. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Diaz-Sandoval LJ, Kosowsky BD and Losordo DW: Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial). Am J Cardiol. 89:356–358. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Kay J, Chow WH, Chan TM, Lo SK, Kwok OH, Yip A, Fan K, Lee CH and Lam WF: Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: A randomized controlled trial. JAMA. 289:553–558. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Shyu KG, Cheng JJ and Kuan P: Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure. J Am Coll Cardiol. 40:1383–1388. 2002. View Article : Google Scholar : PubMed/NCBI

22 

ACT Investigators, . Acetylcysteine for prevention of renal outcomes in patients undergoing coronary and peripheral vascularangiography: Main results from the randomized Acetylcysteine for Contrast-induced nephropathy Trial (ACT). Circulation. 124:1250–1259. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Allaqaband S, Tumuluri R, Malik AM, Gupta A, Volkert P, Shalev Y and Bajwa TK: Prospective randomized study of N-acetylcysteine, fenoldopam and saline for prevention of radiocontrast-induced nephropathy. Catheter Cardiovasc Interv. 57:279–283. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Amini M, Salarifar M, Amirbaigloo A, Masoudkabir F and Esfahani F: N-acetylcysteine does not prevent contrast-induced nephropathy after cardiac catheterization in patients with diabetes mellitus and chronic kidney disease: A randomized clinical trial. Trials. 10:452009. View Article : Google Scholar : PubMed/NCBI

25 

Baskurt M, Okcun B, Abaci O, Dogan GM, Kilickesmez K, Ozkan AA, Ersanli M and Gurmen T: N-acetylcysteine versus N-acetylcysteine+theophylline for the prevention of contrast nephropathy. Eur J Clin Invest. 39:793–179. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Oldemeyer JB, Biddle WP, Wurdeman RL, Mooss AN, Cichowski E and Hilleman DE: Acetylcysteine in the prevention of contrast induced nephropathy after coronary angiography. Am Heart J. 146:E232003. View Article : Google Scholar : PubMed/NCBI

27 

Durham JD, Caputo C, Dokko J, Zaharakis T, Pahlavan M, Keltz J, Dutka P, Marzo K, Maesaka JK and Fishbane S: A randomized controlled trial of N-acetylcysteine to prevent contrast nephropathy in cardiac angiography. Kidney Int. 62:2202–2207. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Ferrario F, Barone MT, Landoni G, Genderini A, Heidemperger M, Trezzi M, Piccaluga E, Danna P and Scorza D: Acetylcysteine and non-ionic isosmolar contrast-induced nephropathy - a randomized controlled study. Nephrol Dial Transplant. 24:3103–3107. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Fung JW, Szeto CC, Chan WW, Kum LC, Chan AK, Wong JT, Wu EB, Yip GW, Chan JY, Yu CM, et al: Effect of N-acetylcysteine for prevention of contrast nephropathy in patients with moderate to severe renal insufficiency: A randomized trial. Am J Kidney Dis. 43:801–808. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Goldenberg I, Shechter M, Matetzky S, Jonas M, Adam M, Pres H, Elian D, Agranat O, Schwammenthal E and Guetta V: Oral acetylcysteine as an adjunct to saline hydration for the prevention of contrast-induced nephropathy following coronary angiography. A randomized controlled trial and review of the current literature. Eur Heart J. 25:212–218. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Gomes VO, de Figueredo CE Poli, Caramori P, Lasevitch R, Bodanese LC, Araújo A, Röedel AP, Caramori AP, Brito FS Jr, Bezerra HG, et al: N-acetylcysteine does not prevent contrast induced nephropathy after cardiac catheterisation with an ionic low osmolality contrast medium: A multicentre clinical trial. Heart. 91:774–778. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Kimmel M, Butscheid M, Brenner S, Kuhlmann U, Klotz U and Alscher DM: Improved estimation of glomerular filtration rate by serum cystatin C in preventing contrast induced nephropathy by N-acetylcysteine or zinc - preliminary results. Nephrol Dial Transplant. 23:1241–1245. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Ozcan EE, Guneri S, Akdeniz B, Akyildiz IZ, Senaslan O, Baris N, Aslan O and Badak O: Sodium Bicarbonate, N-acetylcysteine and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J. 154:539–544. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Yang K, Liu W, Ren W and Lv S: Different interventions in preventing contrast-induced nephropathy after percutaneous coronary intervention. Int Urol Nephrol. 46:1801–1807. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS, European Association for Percutaneous Cardiovascular Interventions (EAPCI), ; Wijns W, Kolh P, Danchin N, Di Mario C, Falk V, Folliguet T, Garg S, Huber K, et al: Guidelines on myocardial revascularization. Eur Heart J. 31:2501–2555. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Stephan Windecker, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, Jüni P, et al: 2014 ESC/EACTS guidelines on myocardial revascularization. Rev Esp Cardiol (Engl Ed). 68:1442015.PubMed/NCBI

37 

Nash K, Hafeez A and Hou S: Hospital-acquired renal insufficiency. Am J Kidney Dis. 39:930–936. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Morcos SK, Thomsen HS and Webb JA: Contrast-media-induced nephrotoxicity: A consensus report. Contrast Media Safety Committee, European Society of Urogenital Radiology (ESUR). Eur Radiol. 9:1602–1613. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Stacul F, van der Molen AJ, Reimer P, Webb JA, Thomsen HS, Morcos SK, Almén T, Aspelin P, Bellin MF, Clement O, et al: Contrast induced nephropathy: Updated ESUR contrast media safety committee guidelines. Eur Radiol. 21:2527–2541. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Waikar SS and Bonventre JV: Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol. 20:672–679. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Thomsen HS and Morcos SK: Risk of contrast-medium-induced nephropathy in high-risk patients undergoing MDCT - a pooled analysis of two randomized trials. Eur Radiol. 19:891–897. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Reddan D, Laville M and Garovic VD: Contrast-induced nephropathy and its prevention: What do we really know from evidence-based findings? J Nephrol. 22:333–351. 2009.PubMed/NCBI

43 

Toprak O: What is the best definition of contrast-induced nephropathy? Ren Fail. 29:387–388. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, Li Y, Xu JS, Huang SM, Wang LN, Huang W, et al: Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol. 17:2937–2944. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Bräutigam M and Persson PB: Do iodinated contrast media interfere with renal tubular creatinine secretion? Radiology. 240:6152006. View Article : Google Scholar : PubMed/NCBI

46 

Sun Z, Fu Q, Cao L, Jin W, Cheng L and Li Z: Intravenous N-acetylcysteine for prevention of contrast-induced nephropathy: A meta-analysis of randomized, controlled trials. PLoS One. 8:e551242013. View Article : Google Scholar : PubMed/NCBI

47 

Kim BJ, Sung KC, Kim BS, Kang JH, Lee KB, Kim H and Lee MH: Effect of N-acetylcysteine on cystatin C-based renal function after elective coronary angiography (ENABLE Study): A prospective, randomized trial. Int J Cardiol. 138:239–245. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Molitoris BA, Levin A, Warnock DG, Joannidis M, Mehta RL, Kellum JA, Ronco C and Shah SV; Acute Kidney Injury Network working group, : Improving outcomes of acute kidney injury: report of an initiative. Nat Clin Pract Nephrol. 3:439–442. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Chen Y, Hu S, Liu Y, Zhao R, Wang L, Fu G, He Q, Su X, Zheng Y, Qi X, et al: Renal tolerability of iopromide and iodixanol in 562 renally impaired patients undergoing cardiac catheterisation: The DIRECT study. EuroIntervention. 8:830–838. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Stacul F, Adam A, Becker CR, Davidson C, Lameire N, McCullough PA and Tumlin J; CIN Consensus Working Panel, : Strategies to reduce the risk of contrast-induced nephropathy. Am J Cardiol. 98:59K–77K. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Mueller C, Buerkle G, Buettner HJ, Petersen J, Perruchoud AP, Eriksson U, Marsch S and Roskamm H: Prevention of contrast media-associated nephropathy: randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty. Arch Intern Med. 162:329–336. 2002. View Article : Google Scholar : PubMed/NCBI

52 

Erley CM, Duda SH, Rehfuss D, Scholtes B, Bock J, Müller C, Osswald H and Risler T: Prevention of radiocontrast-media-induced nephropathy in patients with pre-existing renal insufficiency by hydration in combination with the adenosine antagonist theophylline. Nephrol Dial Transplant. 14:1146–1149. 1999. View Article : Google Scholar : PubMed/NCBI

53 

Sendeski M, Patzak A and Persson PB: Constriction of the vasa recta, the vessels supplying the area at risk for acute kidney injury, by four different iodinated contrast media, evaluating ionic, nonionic, monomeric and dimeric agents. Invest Radiol. 45:453–457. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Seeliger E, Sendeski M, Rihal CS and Persson PB: Contrast-induced kidney injury: Mechanisms, risk factors, and prevention. Eur Heart J. 33:2007–2015. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Seeliger E, Lenhard DC and Persson PB: Contrast media viscosity versus osmolality in kidney injury: Lessons from animal studies. Biomed Res Int. 2014:3581362014. View Article : Google Scholar : PubMed/NCBI

56 

Parfrey P: The clinical epidemiology of contrast-induced nephropathy. Cardiovasc Intervent Radiol. 28 Suppl 2:S3–S11. 2005. View Article : Google Scholar : PubMed/NCBI

57 

Kiefer P, Vogt J and Radermacher P: From mucolytic to antioxidant and liver protection: New aspects in the intensive care unit career of N-acetylcysteine. Crit Care Med. 28:3935–3936. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Efrati S, Dishy V, Averbukh M, Blatt A, Krakover R, Weisgarten J, Morrow JD, Stein MC and Golik A: The effect of N-acetylcysteine on renal function, nitric oxide, and oxidative stress after angiography. Kidney Int. 64:2182–2187. 2003. View Article : Google Scholar : PubMed/NCBI

59 

Quintavalle C, Brenca M, De Micco F, Fiore D, Romano S, Romano MF, Apone F, Bianco A, Zabatta MA, Troncone G, et al: In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis. Cell Death Dis. 2:e1552011. View Article : Google Scholar : PubMed/NCBI

60 

Li JX, Shen YQ, Cai BZ, Zhao J, Bai X, Lu YJ and Li XQ: Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation. Mol Biol Rep. 37:1569–1576. 2010. View Article : Google Scholar : PubMed/NCBI

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Li JX, Jin EZ, Yu LH, Li Y, Liu NN, Dong YM, Li X and Li XQ: Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis. Exp Ther Med 14: 1568-1576, 2017.
APA
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y. ... Li, X. (2017). Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis. Experimental and Therapeutic Medicine, 14, 1568-1576. https://doi.org/10.3892/etm.2017.4678
MLA
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y., Li, X., Li, X."Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis". Experimental and Therapeutic Medicine 14.2 (2017): 1568-1576.
Chicago
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y., Li, X., Li, X."Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1568-1576. https://doi.org/10.3892/etm.2017.4678
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Spandidos Publications style
Li JX, Jin EZ, Yu LH, Li Y, Liu NN, Dong YM, Li X and Li XQ: Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis. Exp Ther Med 14: 1568-1576, 2017.
APA
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y. ... Li, X. (2017). Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis. Experimental and Therapeutic Medicine, 14, 1568-1576. https://doi.org/10.3892/etm.2017.4678
MLA
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y., Li, X., Li, X."Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis". Experimental and Therapeutic Medicine 14.2 (2017): 1568-1576.
Chicago
Li, J., Jin, E., Yu, L., Li, Y., Liu, N., Dong, Y., Li, X., Li, X."Oral N‑acetylcysteine for prophylaxis of contrast‑induced nephropathy in patients following coronary angioplasty: A meta‑analysis". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1568-1576. https://doi.org/10.3892/etm.2017.4678
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