Anti‑exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

  • Authors:
    • Songmei Sun
    • Xing Du
    • Mengxin Xu
    • Meijuan Liu
    • Zhifeng Liu
  • View Affiliations

  • Published online on: June 27, 2017     https://doi.org/10.3892/etm.2017.4679
  • Pages: 1837-1845
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Abstract

The present study aimed to investigate the anti‑exudative effects of sodium ferulate combined with oxymatrine in a mouse model of acetic acid‑induced peritonitis. Furthermore, the underlying mechanisms were explored by determining the effects of these drugs on the volume and aquaporin 1 (AQP1) expression in vascular endothelial cells on omentum majus and human umbilical vein endothelial cells (HUVEC). Treatment with sodium ferulate combined with oxymatrine was shown to significantly inhibit acetic acid‑induced vascular permeability in the peritonitis model mice and furthermore to significantly decrease the optical density of Evans blue, the leukocyte number and the levels of interleukin‑6, C‑reactive protein and interferon‑γ in peritoneal lavage fluid. Pathological analysis of the omentum majus revealed that sodium ferulate and oxymatrine combination treatment significantly alleviated vascular endothelial cell edema and capillary loss. In vitro, flow cytometry revealed that the volume of HUVECs was significantly reduced in the drug treatment groups, as reflected in the forward scatter value. The optical density of AQP1 on the membrane of the vascular endothelial cells on omentum majus and HUVECs were significantly increased in the drug treatment groups compared with the model group. These results indicated that sodium ferulate and oxymatrine combination treatment possessed prominent anti‑exudative effects and that the underlying mechanisms are likely to include the improvement of vascular endothelial cellular edema, possibly by upregulation of AQP1 expression on their membrane, which requires further exploration.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Sun S, Du X, Xu M, Liu M and Liu Z: Anti‑exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1. Exp Ther Med 14: 1837-1845, 2017
APA
Sun, S., Du, X., Xu, M., Liu, M., & Liu, Z. (2017). Anti‑exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1. Experimental and Therapeutic Medicine, 14, 1837-1845. https://doi.org/10.3892/etm.2017.4679
MLA
Sun, S., Du, X., Xu, M., Liu, M., Liu, Z."Anti‑exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1". Experimental and Therapeutic Medicine 14.2 (2017): 1837-1845.
Chicago
Sun, S., Du, X., Xu, M., Liu, M., Liu, Z."Anti‑exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1837-1845. https://doi.org/10.3892/etm.2017.4679