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Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1

  • Authors:
    • Xiaolu Cui
    • Hongquan Song
    • Jie Su
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation Medicine, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China, Department of Spleen and Stomach, Affiliated Hospital of Shandong University of TCM, Jinan, Shandong 250013, P.R. China, Department of Cadres and Health Care, The Second Affiliated Hospital of Shandong University of TCM, Jinan, Shandong 250001, P.R. China
    Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1512-1518
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    Published online on: June 27, 2017
       https://doi.org/10.3892/etm.2017.4683
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Abstract

Curcumin has previously demonstrated anti‑inflammatory, anti‑infective and immuno‑suppressive effects. In the present study, whether the attenuating effects of curcumin against hypoxic‑ischemic brain injury in neonatal rats are mediated via nuclear factor erythroid‑2‑related factor 2 (Nrf2) and heme oxygenase‑1 (HO‑1) was investigated. A model of hypoxic‑ischemic brain injury was created using 1‑week‑old Sprague Dawley rats (weight, 52±1 g). The model rats were treated with 150 mg/kg curcumin by gavage for 3 days. Malondialdehyde levels, and superoxide dismutase and caspase‑3 activities were assayed using commercial kits and western blot analysis was used to measure inducible nitric oxide synthase (iNOS), Nrf2 and HO‑1 expression levels. Treatment with curcumin effectively reduced the brain injury score, increased myelin basic protein (MBP) expression and increased the quantity of neuronal cells in neonatal rats with hypoxic‑ischemic brain injury. Furthermore, treatment with curcumin significantly attenuated the changes in SOD activity and MDA levels and suppressed the iNOS protein expression induced in neonatal rats by hypoxic‑ischemic brain injury. Treatment with curcumin significantly increased Nrf2 and HO‑1 expression in the neonatal rats with hypoxic‑ischemic brain injury. The present study indicated that curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through the induction of Nrf2 and HO‑1.
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Copy and paste a formatted citation
Spandidos Publications style
Cui X, Song H and Su J: Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1. Exp Ther Med 14: 1512-1518, 2017.
APA
Cui, X., Song, H., & Su, J. (2017). Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1. Experimental and Therapeutic Medicine, 14, 1512-1518. https://doi.org/10.3892/etm.2017.4683
MLA
Cui, X., Song, H., Su, J."Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1". Experimental and Therapeutic Medicine 14.2 (2017): 1512-1518.
Chicago
Cui, X., Song, H., Su, J."Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1512-1518. https://doi.org/10.3892/etm.2017.4683
Copy and paste a formatted citation
x
Spandidos Publications style
Cui X, Song H and Su J: Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1. Exp Ther Med 14: 1512-1518, 2017.
APA
Cui, X., Song, H., & Su, J. (2017). Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1. Experimental and Therapeutic Medicine, 14, 1512-1518. https://doi.org/10.3892/etm.2017.4683
MLA
Cui, X., Song, H., Su, J."Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1". Experimental and Therapeutic Medicine 14.2 (2017): 1512-1518.
Chicago
Cui, X., Song, H., Su, J."Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1512-1518. https://doi.org/10.3892/etm.2017.4683
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