Open Access

SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes

  • Authors:
    • Fei Mao
    • Siying Liu
    • Xiaona Qiao
    • Hangping Zheng
    • Qian Xiong
    • Jie Wen
    • Shuo Zhang
    • Zhaoyun Zhang
    • Hongying Ye
    • Hongli Shi
    • Bin Lu
    • Yiming Li
  • View Affiliations

  • Published online on: June 27, 2017     https://doi.org/10.3892/etm.2017.4689
  • Pages: 1343-1350
  • Copyright: © Mao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

SUDOSCAN is a non‑invasive method of measuring peripheral small fiber and autonomic nerve activity by detection of abnormal sweat gland function through electrochemical skin conductance. It has been reported to be an effective screening tool in early detection of microvascular type 2 diabetes mellitus (T2DM) complications including diabetic neuropathy and nephropathy in recent studies. However, previous studies used estimated glomerular filtration rate (eGFR) as the golden standard, which has a 90% chance of being within 30% of the measured GFR at best. No relevant study has been performed in the Chinese population concerning SUDOSCAN in the screening of diabetic nephropathy (DN) in comparison with GFR. In this cross‑sectional study, SUDOSCAN was performed in 176 Chinese patients with T2DM between September 2014 and September 2015. It was found that the SUDOSCAN test had a sensitivity of 57.8% and a specificity of 100% to detect chronic kidney disease at a cut‑off SUDOSCAN‑DN score of 59.5. The area under receiver operating characteristic curve for DN was 0.85 [95% confidence interval (CI), 0.76‑0.93] compared with 0.84 for eGFRMDRD (MDRD, modification of diet in renal disease; 95% CI, 0.71‑0.98) and 0.77 for eGFREPI (EPI, epidemiology collaboration; 95% CI, 0.68‑0.87). Patients with DN score <59.5 had a significantly lower GFR level (P<0.001) and significantly older age (P<0.001), longer duration of T2DM (P<0.001) and higher risk of diabetic complications, including diabetic neuropathy (P<0.001) and peripheral vascular disease (P<0.05). These results suggested that SUDOSCAN may be useful for detecting patients at risk of impaired renal function as part of a screening program in the Chinese population with T2DM.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Mao F, Liu S, Qiao X, Zheng H, Xiong Q, Wen J, Zhang S, Zhang Z, Ye H, Shi H, Shi H, et al: SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes. Exp Ther Med 14: 1343-1350, 2017
APA
Mao, F., Liu, S., Qiao, X., Zheng, H., Xiong, Q., Wen, J. ... Li, Y. (2017). SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes. Experimental and Therapeutic Medicine, 14, 1343-1350. https://doi.org/10.3892/etm.2017.4689
MLA
Mao, F., Liu, S., Qiao, X., Zheng, H., Xiong, Q., Wen, J., Zhang, S., Zhang, Z., Ye, H., Shi, H., Lu, B., Li, Y."SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes". Experimental and Therapeutic Medicine 14.2 (2017): 1343-1350.
Chicago
Mao, F., Liu, S., Qiao, X., Zheng, H., Xiong, Q., Wen, J., Zhang, S., Zhang, Z., Ye, H., Shi, H., Lu, B., Li, Y."SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1343-1350. https://doi.org/10.3892/etm.2017.4689