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Article Open Access

Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease

  • Authors:
    • Xin-Guo Peng
    • Yu-Yuan Li
    • Hui-Ting Chen
    • Yan Zhou
    • Jian-Guo Ma
    • Hong-Min Yin
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P.R. China, Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510000, P.R. China, Department of General Surgery, Yantai Mountain Hospital, Yantai, Shandong 264000, P.R. China, Department of Gastroenterology, Binzhou Central Hospital, Binzhou, Shandong 256603, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1487-1490
    |
    Published online on: June 27, 2017
       https://doi.org/10.3892/etm.2017.4696
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Abstract

The present study was planned to evaluate correlation between Helicobacter pylori (HP) infection and autoimmune liver disease (AILD). A total of 60 patients diagnosed with AILD in Affiliated Hospital of Binzhou Medical College were continuously enrolled in the present study. HP infection was detected by 13C-urea breath test. The levels of anti-myeloperoxidase were tested by ELISA. The positive rate of anti-nuclear antibody (ANA), anti-mitochondrial antibody (AMA), anti-smooth muscle antibody (SMA) and anti-neutrophil cytoplasm antibody (ANCA) were tested by indirect immunofluorescence. The positive rates of anti-mitochondrial antibody (AMA-M2), anti-liver-kidney microsomal antibody (LKM-1), anti-liver cytoplasm antibody I (LC-1) and anti-soluble liver antigen/liver-pancreas antigen (SLA/LP) were tested by immunoblotting. Liver function indexes including alanine transaminase, aspartate transaminase, alkaline phosphatase and glutamyltransferase, were analyzed with a fully automatic biochemical analyzer. The levels of serum cytokine IFN-γ, interleukin-6 (IL-6), IL-10 and tumor necrosis factor-α (TNF-α) were tested by ELISA. A total of 37 patients (61.67%) were observed to be HP-positive. MPO-positive rate, positive rate of ANA, AMA, SMA and ANCA and positive rate of AMA-M2, LKM-1, LC-1 and SLA/LP in patients with positive HP infection were significantly higher than those of patients with negative HP infection. On the other hand, the levels of liver function indices did not showed any significant differences among HP-positive cases or HP-negative cases. However, the levels of IFN-γ, IL-6, IL-10 and TNF-α in patients with positive HP infection were significantly higher than those of patients with negative HP infection. In conclusion, the positive infection rate of HP infection in patients with AILD is high and is closely associated with various positive immune antibodies as well as cytokine levels.
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1 

Montano-Loza AJ, Thandassery RB and Czaja AJ: Targeting hepatic fibrosis in autoimmune hepatitis. Dig Dis Sci. 61:3118–3139. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Czaja AJ: Nature and implications of oxidative and nitrosative stresses in autoimmune hepatitis. Dig Dis Sci. 13:122–123. 2016.

3 

Yeo SH and Yang CH: Peptic ulcer disease associated with Helicobacter pylori infection. Korean J Gastroenterol. 67:289–299. 2016.(In Korean). View Article : Google Scholar : PubMed/NCBI

4 

El-Matary W, Dalzell AM and Ashworth M: Helicobacter pylori and autoimmune hepatitis. Eur J Pediatr. 164:54–55. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Muratori P, Lalanne C, Bianchi G, Lenzi M and Muratori L: Predictive factors of poor response to therapy in autoimmune hepatitis. Dig Liver Dis. 48:1078–1081. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Utiyama SR, Zenatti KB, Nóbrega HA, Soares JZ, Skare TL, Matsubara C, Muzzilo DA and Nisihara RM: Rheumatic disease autoantibodies in autoimmune liver diseases. Immunol Invest. 45:566–573. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Muratori L, Deleonardi G, Lalanne C, Barbato E, Tovoli A, Libra A, Lenzi M, Cassani F and Muratori P: Autoantibodies in autoimmune hepatitis. Dig Dis. 33 Suppl 2:65–69. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Tomizawa M, Shinozaki F, Fugo K, Motoyoshi Y, Sugiyama T, Yamamoto S, Kishimoto T and Ishige N: Anti-mitochondrial M2 antibody-positive autoimmune hepatitis. Exp Ther Med. 10:1419–1422. 2015.PubMed/NCBI

9 

Sun L, Wang Y, Liu Y, Zhao Y, Zhang X, Wang Y, Zhao D, Zhang H and Ma Y: Differential characteristics of AMA-M2 autoantibody in primary biliary cirrhosis and non-PBC patients. Zhonghua Gan Zang Bing Za Zhi. 23:343–349. 2015.(In Chinese). PubMed/NCBI

10 

Longhi MS, Mieli-Vergani G and Vergani D: Autoimmune hepatitis. Curr Pediatr Rev. 10:268–274. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Stinton LM, Bentow C, Mahler M, Norman GL, Eksteen B, Mason AL, Kaplan GG, Lindkvist B, Hirschfield GM, Milkiewicz P, et al: PR3-ANCA: A promising biomarker in primary sclerosing cholangitis (PSC). PLoS One. 9:e1128772014. View Article : Google Scholar : PubMed/NCBI

12 

Nagai T, Imamura M, Kamiya Y and Mori M: Graves' disease accompanied by anti-myeloperoxidase antibody-related nephropathy and autoimmune hepatitis. Intern Med. 43:516–520. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Liberal R, Grant CR, Longhi MS, Mieli-Vergani G and Vergani D: Diagnostic criteria of autoimmune hepatitis. Autoimmun Rev. 13:435–440. 2014. View Article : Google Scholar : PubMed/NCBI

14 

An IC, Tiwari AK, Ameda S and Laird-Fick HS: Autoimmune hepatitis: Diagnostic dilemma in the setting of suspected iron overload. Case Rep Gastrointest Med. 2013:8729872013.PubMed/NCBI

15 

Silva LD, Rocha AM, Rocha GA, de Moura SB, Rocha MM, Dani R, de Melo FF, Guerra JB, de Castr LP, Mendes GS, et al: The presence of Helicobacter pylori in the liver depends on the Th1, Th17 and Treg cytokine profile of the patient. Mem Inst Oswaldo Cruz. 106:748–754. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Mackay IR, Leskovsek NV and Rose NR: Cell damage and autoimmunity: A critical appraisal. J Autoimmun. 30:5–11. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Dzierzanowska-Fangrat K, Nilsson I, Wozniak M, Jozwiak P, Rozynek E, Woynarowski M, Socha J, Ljungh A and Wadström T: Lack of an association between Helicobacter infection and autoimmune hepatitis in children. Pol J Microbiol. 55:157–159. 2006.PubMed/NCBI

18 

Vorobjova T, Nilsson I, Terjajev S, Granholm M, Lyyra M, Porkka T, Prükk T, Salupere R, Maaroos HI and Wadström T: Serum antibodies to enterohepatic Helicobacter spp. in patients with chronic liver diseases and in a population with high prevalence of H. pylori infection. Dig Liver Dis. 38:171–176. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Durazzo M, Pellicano R, Premoli A, Berrutti M, Leone N, Ponzetto A and Rizzetto M: Helicobacter pylori seroprevalence in patients with autoimmune hepatitis. Dig Dis Sci. 47:380–383. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Galperin C and Gershwin ME: Immunopathogenesis of gastrointestinal and hepatobiliary diseases. JAMA. 278:1946–1955. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Peng X, Li Y, Chen H, Zhou Y, Ma J and Yin H: Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease. Exp Ther Med 14: 1487-1490, 2017.
APA
Peng, X., Li, Y., Chen, H., Zhou, Y., Ma, J., & Yin, H. (2017). Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease. Experimental and Therapeutic Medicine, 14, 1487-1490. https://doi.org/10.3892/etm.2017.4696
MLA
Peng, X., Li, Y., Chen, H., Zhou, Y., Ma, J., Yin, H."Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease". Experimental and Therapeutic Medicine 14.2 (2017): 1487-1490.
Chicago
Peng, X., Li, Y., Chen, H., Zhou, Y., Ma, J., Yin, H."Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1487-1490. https://doi.org/10.3892/etm.2017.4696
Copy and paste a formatted citation
x
Spandidos Publications style
Peng X, Li Y, Chen H, Zhou Y, Ma J and Yin H: Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease. Exp Ther Med 14: 1487-1490, 2017.
APA
Peng, X., Li, Y., Chen, H., Zhou, Y., Ma, J., & Yin, H. (2017). Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease. Experimental and Therapeutic Medicine, 14, 1487-1490. https://doi.org/10.3892/etm.2017.4696
MLA
Peng, X., Li, Y., Chen, H., Zhou, Y., Ma, J., Yin, H."Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease". Experimental and Therapeutic Medicine 14.2 (2017): 1487-1490.
Chicago
Peng, X., Li, Y., Chen, H., Zhou, Y., Ma, J., Yin, H."Evolution of correlation between Helicobacter pylori infection and autoimmune liver disease". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1487-1490. https://doi.org/10.3892/etm.2017.4696
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