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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article Open Access

Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway

  • Authors:
    • Yue Wang
    • Huimin Mo
    • Jun Gu
    • Kan Chen
    • Zhihua Han
    • Yi Liu

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Ninth People's Hospital, Shanghai Jiaotong University Medical School, Shanghai 200011, P.R. China, Institute of Hematology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Ultrasound, Renji Hospital, Shanghai Jiaotong University Medical School, Shanghai 200127, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3067-3073
    |
    Published online on: July 31, 2017
       https://doi.org/10.3892/etm.2017.4855
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Abstract

The aim of the present study was to examine the apoptotic effect of cordycepin (COR) on human THP-1 acute monocytic leukemia cells. THP-1 cells were exposed to different concentrations of COR for 24, 48, 72 or 96 h. The cell viability and apoptotic rate were analyzed. The gene expression of Akt1, Akt2, Akt3, B‑cell lymphoma 2 (Bcl‑2) and Bcl‑2‑associated X protein (Bax) were assessed by reverse‑transcription quantitative PCR. Western blot analysis was used to detect the protein levels of phosphorylated (p)‑Akt, p‑extracellular signal‑regulated kinase (ERK) and cleaved caspase‑3. It was found that the viability of THP‑1 cells was inhibited by COR in a dose‑ and time‑dependent manner. After treatment with 200 µM COR for 24 h, the percentage of apoptotic cells was significantly increased. COR also downregulated the levels of Bcl‑2, Akt1, Akt2 and Akt3, and elevated the expression of Bax. The protein levels of p‑Akt and p‑ERK were suppressed and cleaved caspase‑3 was increased after treatment of COR. In conclusion, COR was found to induce apoptosis of THP‑1 acute monocytic leukemia cells through downregulation of ERK/Akt signaling.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Mo H, Gu J, Chen K, Han Z and Liu Y: Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway. Exp Ther Med 14: 3067-3073, 2017.
APA
Wang, Y., Mo, H., Gu, J., Chen, K., Han, Z., & Liu, Y. (2017). Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway. Experimental and Therapeutic Medicine, 14, 3067-3073. https://doi.org/10.3892/etm.2017.4855
MLA
Wang, Y., Mo, H., Gu, J., Chen, K., Han, Z., Liu, Y."Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway". Experimental and Therapeutic Medicine 14.4 (2017): 3067-3073.
Chicago
Wang, Y., Mo, H., Gu, J., Chen, K., Han, Z., Liu, Y."Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3067-3073. https://doi.org/10.3892/etm.2017.4855
Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Mo H, Gu J, Chen K, Han Z and Liu Y: Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway. Exp Ther Med 14: 3067-3073, 2017.
APA
Wang, Y., Mo, H., Gu, J., Chen, K., Han, Z., & Liu, Y. (2017). Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway. Experimental and Therapeutic Medicine, 14, 3067-3073. https://doi.org/10.3892/etm.2017.4855
MLA
Wang, Y., Mo, H., Gu, J., Chen, K., Han, Z., Liu, Y."Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway". Experimental and Therapeutic Medicine 14.4 (2017): 3067-3073.
Chicago
Wang, Y., Mo, H., Gu, J., Chen, K., Han, Z., Liu, Y."Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3067-3073. https://doi.org/10.3892/etm.2017.4855
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