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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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Article Open Access

Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway

  • Authors:
    • Xinle Zhang
    • Liyi Zou
    • Jin Li
    • Bilian Xu
    • Tie Wu
    • Huanqiong Fan
    • Weiming Xu
    • Weimin Yao
    • Yajun Yang
    • Yuyu Liu
    • Liao Cui

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China, Department of Respiratory Medicine, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2779-2788
    |
    Published online on: August 9, 2017
       https://doi.org/10.3892/etm.2017.4914
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Abstract

The aim of the present study was to investigate the effect of salvianolic acid B (Sal B) and danshensu (DSU) on the osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) and the mechanisms of the effects. The osteogenic differentiation of MSCs in culture was assessed by measuring alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, nitric oxide (NO) production and the mRNA expression levels of osteoprotegerin (OPG) and its ligand by MSCs. MSCs were successfully induced to differentiate into osteoblasts and adipocytes. Sal B and DSU increased the ALP activity and the production of OCN in the absence of an ossification inducer. The increase in ALP activity was more pronounced when induction was combined with the osteogenic inducer, Sal B, which enhanced the expression of OPG; however, Sal B reduced the expression of receptor activator of nuclear factor‑κB ligand (RANKL) by MSCs. Sal B reversed the inhibitory effect of N‑nitro L‑arginine methylester on the MSCs and increased ALP activity, OCN content and the OPG/RANKL ratio. Based on these results, it was concluded that Sal B increases the osteogenic differentiation of MSCs, most likely by regulating the nitric oxide pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Zou L, Li J, Xu B, Wu T, Fan H, Xu W, Yao W, Yang Y, Liu Y, Liu Y, et al: Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway. Exp Ther Med 14: 2779-2788, 2017.
APA
Zhang, X., Zou, L., Li, J., Xu, B., Wu, T., Fan, H. ... Cui, L. (2017). Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway. Experimental and Therapeutic Medicine, 14, 2779-2788. https://doi.org/10.3892/etm.2017.4914
MLA
Zhang, X., Zou, L., Li, J., Xu, B., Wu, T., Fan, H., Xu, W., Yao, W., Yang, Y., Liu, Y., Cui, L."Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway". Experimental and Therapeutic Medicine 14.4 (2017): 2779-2788.
Chicago
Zhang, X., Zou, L., Li, J., Xu, B., Wu, T., Fan, H., Xu, W., Yao, W., Yang, Y., Liu, Y., Cui, L."Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway". Experimental and Therapeutic Medicine 14, no. 4 (2017): 2779-2788. https://doi.org/10.3892/etm.2017.4914
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Zou L, Li J, Xu B, Wu T, Fan H, Xu W, Yao W, Yang Y, Liu Y, Liu Y, et al: Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway. Exp Ther Med 14: 2779-2788, 2017.
APA
Zhang, X., Zou, L., Li, J., Xu, B., Wu, T., Fan, H. ... Cui, L. (2017). Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway. Experimental and Therapeutic Medicine, 14, 2779-2788. https://doi.org/10.3892/etm.2017.4914
MLA
Zhang, X., Zou, L., Li, J., Xu, B., Wu, T., Fan, H., Xu, W., Yao, W., Yang, Y., Liu, Y., Cui, L."Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway". Experimental and Therapeutic Medicine 14.4 (2017): 2779-2788.
Chicago
Zhang, X., Zou, L., Li, J., Xu, B., Wu, T., Fan, H., Xu, W., Yao, W., Yang, Y., Liu, Y., Cui, L."Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway". Experimental and Therapeutic Medicine 14, no. 4 (2017): 2779-2788. https://doi.org/10.3892/etm.2017.4914
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