Sevoflurane may be more beneficial than propofol in patients receiving endoscopic variceal ligation and endoscopic variceal sclerotherapy: A randomized, double-blind study

  • Authors:
    • Linghua Tang
    • Huimin Liu
    • Yang Wu
    • Mei Li
    • Wei Li
    • Meng Jiang
    • Jiabao Hou
    • Ying Jiang
    • Zhongyuan Xia
    • Qingtao Meng
  • View Affiliations

  • Published online on: August 9, 2017     https://doi.org/10.3892/etm.2017.4919
  • Pages: 3145-3152
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Abstract

The aim of the present study was to evaluate the safety and efficacy of various general anesthesia regimens during endoscopic variceal ligation (EVL) and endoscopic variceal sclerotherapy (EVS). A total of 123 patients with American Society of Anesthesiologists physical status III and IV, aged 40‑70 years, undergoing general anesthesia for EVL and EVS were randomly divided into two groups: Sevoflurane anesthesia (group S; n=60) and propofol anesthesia (group P; n=60). Vital signs, particularly heart rate (HR) and mean arterial pressure (MAP), were monitored. The designated time points were as follows: 5 min before induction (T0), and 1, 5, 10, 15, 20, 25 and 30 min after intubation (T1, T2, T3, T4, T5, T6 and T7, respectively). Time intervals were recorded, including recovery time and extubation time. Following surgery, the observer recorded the Ramsay sedation scale (RSS) score and the visual analogue scale (VAS) score. Adverse reactions were noted. Results demonstrated that there were significant differe­nces in MAP between the two groups at T2, T3, T5, T6 and T7 (P<0.05). There was a significant difference in HR between the two groups at T2, T3 and T4 (P<0.05). Recovery time and extubation time in group P were significantly longer than those in group S (P<0.05; 18.38±2.25 min vs. 14.57±1.04 min and 21.70±2.70 min vs. 15.83±0.88 min, respectively). The rate of ephedrine injected was 58.3% (35/60 patients) in group P vs. 28.3% (17/60 patients) in group S (P<0.05). There was a significant difference in the RSS score between the two groups 5 min after extubation (P<0.05). VRS scores demonstrated that anesthetists and patients were significantly more satisfied with the procedure in group S than in group P (P<0.01). In conclusion, the superiority and special clinical value of inhalational anesthesia has been demonstrated during EVL and EVS attributed to stable hemodynamics and high quality of anesthesia recovery in the present study.

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October-2017
Volume 14 Issue 4

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Spandidos Publications style
Tang L, Liu H, Wu Y, Li M, Li W, Jiang M, Hou J, Jiang Y, Xia Z, Meng Q, Meng Q, et al: Sevoflurane may be more beneficial than propofol in patients receiving endoscopic variceal ligation and endoscopic variceal sclerotherapy: A randomized, double-blind study. Exp Ther Med 14: 3145-3152, 2017
APA
Tang, L., Liu, H., Wu, Y., Li, M., Li, W., Jiang, M. ... Meng, Q. (2017). Sevoflurane may be more beneficial than propofol in patients receiving endoscopic variceal ligation and endoscopic variceal sclerotherapy: A randomized, double-blind study. Experimental and Therapeutic Medicine, 14, 3145-3152. https://doi.org/10.3892/etm.2017.4919
MLA
Tang, L., Liu, H., Wu, Y., Li, M., Li, W., Jiang, M., Hou, J., Jiang, Y., Xia, Z., Meng, Q."Sevoflurane may be more beneficial than propofol in patients receiving endoscopic variceal ligation and endoscopic variceal sclerotherapy: A randomized, double-blind study". Experimental and Therapeutic Medicine 14.4 (2017): 3145-3152.
Chicago
Tang, L., Liu, H., Wu, Y., Li, M., Li, W., Jiang, M., Hou, J., Jiang, Y., Xia, Z., Meng, Q."Sevoflurane may be more beneficial than propofol in patients receiving endoscopic variceal ligation and endoscopic variceal sclerotherapy: A randomized, double-blind study". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3145-3152. https://doi.org/10.3892/etm.2017.4919