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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma

  • Authors:
    • Teng Li
    • Yun Liu
    • Yanming Sun

  • View Affiliations / Copyright

    Affiliations: Department of Interventional Radiology, The People's Hospital of Weifang, Weifang, Shandong 261041, P.R. China, Department of Hematology, The People's Hospital of Weifang, Weifang, Shandong 261041, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3419-3424
    |
    Published online on: August 14, 2017
       https://doi.org/10.3892/etm.2017.4927
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Abstract

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and the second most common cause of cancer-related mortalities. With a high potential for metastasis and recurrence, HCC is refractory to cure. The present study aimed to explore the role of a recent‑discovered LncRNA, AB209630, in human HCC, in order to provide new insights useful for clinical HCC diagnosis and treatment. Reverse transcription‑quantitative polymerase chain reaction was performed to examine the expression of AB209630 in cli­nical HCC samples and the adjacent non‑cancerous tissues. The reduced expression of AB209630 observed in HCC tissues and cultured HCC cells compared with normal hepatic tissues and cells prompted the construction of an AB209630‑expressing plasmid with a CBP tag on the plasmid backbone. Cell proli­feration and colony formation assays were conducted to detect the effects of AB209630 on HCC cell proliferation. In addition, Transwell assay and wound‑healing assays were performed, the results of which further indicated that the overexpression of AB209630 inhibited the migration and invasion of HCC cells. These results revealed the inhibitory effects of AB209630 on HCC progression, and suggest the potential of AB209630 as an inhibitor of HCC for clinical use.

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Copy and paste a formatted citation
Spandidos Publications style
Li T, Liu Y and Sun Y: Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma. Exp Ther Med 14: 3419-3424, 2017.
APA
Li, T., Liu, Y., & Sun, Y. (2017). Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma. Experimental and Therapeutic Medicine, 14, 3419-3424. https://doi.org/10.3892/etm.2017.4927
MLA
Li, T., Liu, Y., Sun, Y."Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma". Experimental and Therapeutic Medicine 14.4 (2017): 3419-3424.
Chicago
Li, T., Liu, Y., Sun, Y."Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3419-3424. https://doi.org/10.3892/etm.2017.4927
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Liu Y and Sun Y: Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma. Exp Ther Med 14: 3419-3424, 2017.
APA
Li, T., Liu, Y., & Sun, Y. (2017). Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma. Experimental and Therapeutic Medicine, 14, 3419-3424. https://doi.org/10.3892/etm.2017.4927
MLA
Li, T., Liu, Y., Sun, Y."Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma". Experimental and Therapeutic Medicine 14.4 (2017): 3419-3424.
Chicago
Li, T., Liu, Y., Sun, Y."Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3419-3424. https://doi.org/10.3892/etm.2017.4927
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