Open Access

The combined strategy of mesenchymal stem cells and tissue-engineered scaffolds for spinal cord injury regeneration (Review)

  • Authors:
    • Rosaliana Libro
    • Placido Bramanti
    • Emanuela Mazzon
  • View Affiliations

  • Published online on: August 16, 2017     https://doi.org/10.3892/etm.2017.4939
  • Pages: 3355-3368
  • Copyright: © Libro et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Spinal cord injury (SCI) is a traumatic lesion that can result in the loss of motor or sensory neurons. Stem cell (SC)‑based therapies have been demonstrated to promote neuronal regeneration following SCI, by releasing a range of trophic factors that support endogenous repair or by differentiating into neurons, or glial cells in order to replace the damaged cells. However, numerous limitations remain for therapies based on SC transplantion alone, including a low rate of survival/engraftment. Nevertheless, scaffolds are 3‑dimentional substrates that have revealed to support cell survival, proliferation and differentiation in vivo, by mimicking a more favorable endogenous microenvironment. A multidisciplinary approach, which combines engineered scaffolds with SCs has been proposed as a promising strategy for encouraging spinal cord regeneration. The present review has focused on the regenerative potential of mesenchymal SCs isolated from different sources and combined with various scaffold types, in preclinical and clinical SCI studies.

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October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Libro R, Bramanti P and Mazzon E: The combined strategy of mesenchymal stem cells and tissue-engineered scaffolds for spinal cord injury regeneration (Review). Exp Ther Med 14: 3355-3368, 2017
APA
Libro, R., Bramanti, P., & Mazzon, E. (2017). The combined strategy of mesenchymal stem cells and tissue-engineered scaffolds for spinal cord injury regeneration (Review). Experimental and Therapeutic Medicine, 14, 3355-3368. https://doi.org/10.3892/etm.2017.4939
MLA
Libro, R., Bramanti, P., Mazzon, E."The combined strategy of mesenchymal stem cells and tissue-engineered scaffolds for spinal cord injury regeneration (Review)". Experimental and Therapeutic Medicine 14.4 (2017): 3355-3368.
Chicago
Libro, R., Bramanti, P., Mazzon, E."The combined strategy of mesenchymal stem cells and tissue-engineered scaffolds for spinal cord injury regeneration (Review)". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3355-3368. https://doi.org/10.3892/etm.2017.4939