Overexpression of dominant-negative Ikaros 6 isoform is associated with resistance to TKIs in patients with Philadelphia chromosome positive acute lymphoblastic leukemia

  • Authors:
    • Changfeng Shao
    • Jie Yang
    • Yirong Kong
    • Cong Cheng
    • Wei Lu
    • Hongzai Guan
    • Haiyan Wang
  • View Affiliations

  • Published online on: August 16, 2017     https://doi.org/10.3892/etm.2017.4941
  • Pages: 3874-3879
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The clinical significance of the dominant-negative Ikaros 6 (DN‑IK6) in the treatment of patients with Philadelphia-positive acute lymphoblastic leukemia (Ph+‑ALL) with tyrosine kinase inhibitors (TKIs) remains elusive. In the present study, it was demonstrated that DN‑IK6 was overexpressed in B‑cell (B)‑ALL cases compared with T cell‑ALL cases at the mRNA and protein levels. Furthermore, nucleotide sequencing revealed that DN‑IK6 was due to the deletion of IKAROS family zinc finger 1 exons 4‑7. The outcome of patients with Ph+‑B‑ALL with DN‑IK6, and treated with TKIs and hyper-cyclophosphamide/vincristine/doxorubicin/dexamethasone regimen were restrospectively evaluated in a 2 year follow‑up. The results demonstrated that those with the DN isoform exhibited significantly lower incidences of remission, shorter median cumulative incidence of relapse times (P<0.05) and shorter median overall survival times (P<0.05) compared with those without the DN isoform. In conclusion, the results of the present study demonstrated that DN‑IK6 is overexpressed in the majority of patients with Ph+‑ALL, and is significantly associated with resistance to TKI therapy.

Related Articles

Journal Cover

October 2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Shao, C., Yang, J., Kong, Y., Cheng, C., Lu, W., Guan, H., & Wang, H. (2017). Overexpression of dominant-negative Ikaros 6 isoform is associated with resistance to TKIs in patients with Philadelphia chromosome positive acute lymphoblastic leukemia. Experimental and Therapeutic Medicine, 14, 3874-3879. https://doi.org/10.3892/etm.2017.4941
MLA
Shao, C., Yang, J., Kong, Y., Cheng, C., Lu, W., Guan, H., Wang, H."Overexpression of dominant-negative Ikaros 6 isoform is associated with resistance to TKIs in patients with Philadelphia chromosome positive acute lymphoblastic leukemia". Experimental and Therapeutic Medicine 14.4 (2017): 3874-3879.
Chicago
Shao, C., Yang, J., Kong, Y., Cheng, C., Lu, W., Guan, H., Wang, H."Overexpression of dominant-negative Ikaros 6 isoform is associated with resistance to TKIs in patients with Philadelphia chromosome positive acute lymphoblastic leukemia". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3874-3879. https://doi.org/10.3892/etm.2017.4941