Histological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningocele

Carvalho,Natalia  S.; Moron,Antonio  F.; Menon,Ramkumar; Cavalheiro,Sergio; Barbosa,Mauricio  M.; Milani,Herbene J.; Ishigai,Marcia  M.

doi:10.3892/etm.2017.4976

October-2017 Volume 14 Issue 4

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October-2017 Volume 14 Issue 4

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Article Open Access

Histological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningocele

Authors:
- Natalia S. Carvalho
- Antonio F. Moron
- Ramkumar Menon
- Sergio Cavalheiro
- Mauricio M. Barbosa
- Herbene J. Milani
- Marcia M. Ishigai
View Affiliations / Copyright

Affiliations: Department of Obstetrics, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP 04021‑001, Brazil, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA, Fetal Medicine Division, Hospital e Maternidade Santa Joana, São Paulo, SP 04103‑000, Brazil, Department of Pathology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP 04021‑001, Brazil

Copyright: © Carvalho et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3732-3736
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Published online on: August 21, 2017

https://doi.org/10.3892/etm.2017.4976
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Abstract

An increased understanding of the reparative process in fetal membrane following surgical techniques may be helpful to decrease the risks to mother and fetus and avoid adverse pregnancy outcomes. The present study discusses histological evaluation of the fetal membrane following open fetal surgery. Chorioamniotic membranes (n=10) were obtained following birth from pregnancies that underwent open fetal surgery for myelomeningocele. The collagen distribution was quantified using picrosirius‑polarization method comparing the suture site with non‑suture site. The differences between the collagen fiber percentages at the two sites was evaluated by the paired t‑test with P<0.05. The mean gestational age of fetal surgery was 26.09±0.3 and 33.81±0.82 weeks at birth. The picrosirius red sign was more intense at the suture site, primarily associated with collagen type 1. Collagen observed in the surgical area was significantly increased (13.22±2.84%) compared with the non‑surgical area (6.16±1.09%; P<0.0001). It was observed that the reparative activity at the suture site of the fetal membrane was characterized by a significant increase in collagen fibers. The findings suggest nascent collagen synthesis, tissue remodeling and repair of suture site, a mechanism likely to prevent the amniotic fluid leakage and maintain pregnancy following open fetal surgery.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Histological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningocele

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