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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens

  • Authors:
    • Jun Wang
    • Zhi Peng Gao
    • Song Qin
    • Chang Bai Liu
    • Li Li Zou

  • View Affiliations / Copyright

    Affiliations: Translational Neuroscience and Neural Regeneration and Repair Institute/Institute of Cell Therapy, The First People's Hospital of Yichang, China Three Gorges University, Yichang, Hubei 443000, P.R. China, Department of Microbiology and Immunology, Medical College, China Three Gorges University, Yichang, Hubei 443002, P.R. China
  • Pages: 3399-3406
    |
    Published online on: August 22, 2017
       https://doi.org/10.3892/etm.2017.4989
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Abstract

As a key molecule involved in cell recognition, calreticulin (CRT) may be expressed on the surface of (pre‑) apoptotic cells and provide the signal that is recognized by dendritic cells (DCs) or other antigen presenting cells (APCs), which results in phagocytosis. Within the APCs, tumor‑associated antigens (TAAs) may be subsequently presented to T lymphocytes, which triggers a specific antitumor immune response. It has been hypothesized that CRT is able to act as the immunologic adjuvant and translocate itself and TAAs to the cell surface and induce a specific antitumor immune response. In the present study, CRT was demonstrated to translocate itself and mucin 1 (MUC1), a breast cancer antigen, to the surface of 4T1 cells and the MUC1‑CRT‑coated cells were able to induce apoptosis in a time‑dependent manner. When DCs were infected with adenovirus containing MUC1‑CRT, an increase in T cell proliferation and cytokine production was exhibited. These results suggest that CRT may act as an immunologic adjuvant with MUC1 and induce a strong immune response.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Gao ZP, Qin S, Liu CB and Zou LL: Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens. Exp Ther Med 14: 3399-3406, 2017.
APA
Wang, J., Gao, Z.P., Qin, S., Liu, C.B., & Zou, L.L. (2017). Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens. Experimental and Therapeutic Medicine, 14, 3399-3406. https://doi.org/10.3892/etm.2017.4989
MLA
Wang, J., Gao, Z. P., Qin, S., Liu, C. B., Zou, L. L."Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens". Experimental and Therapeutic Medicine 14.4 (2017): 3399-3406.
Chicago
Wang, J., Gao, Z. P., Qin, S., Liu, C. B., Zou, L. L."Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3399-3406. https://doi.org/10.3892/etm.2017.4989
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Gao ZP, Qin S, Liu CB and Zou LL: Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens. Exp Ther Med 14: 3399-3406, 2017.
APA
Wang, J., Gao, Z.P., Qin, S., Liu, C.B., & Zou, L.L. (2017). Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens. Experimental and Therapeutic Medicine, 14, 3399-3406. https://doi.org/10.3892/etm.2017.4989
MLA
Wang, J., Gao, Z. P., Qin, S., Liu, C. B., Zou, L. L."Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens". Experimental and Therapeutic Medicine 14.4 (2017): 3399-3406.
Chicago
Wang, J., Gao, Z. P., Qin, S., Liu, C. B., Zou, L. L."Calreticulin is an effective immunologic adjuvant to tumor‑associated antigens". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3399-3406. https://doi.org/10.3892/etm.2017.4989
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