Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis

  • Authors:
    • Yuanxin Liu
    • Guilai Zuo
    • Xin Meng
    • Xingxiao Gao
    • Lihai Zhang
    • Peifu Tang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, P.R. China, Department of Orthopaedics, Pingyin People Hospital, Jinan, Shandong 250400, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4009-4016
    |
    Published online on: August 24, 2017
       https://doi.org/10.3892/etm.2017.5025
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The current study aimed to improve the understanding on the association between adrenomedullin and osteoporosis in mice with glucocorticoid‑induced osteoporosis. Bone resorption and osteoporosis‑associated indexes, including maximum load, stiffness, energy to failure, ultimate strength, elastic modulus, post‑yield displacement and post‑yield displacement, in mice with osteoporosis were analyzed in order to evaluate the effect of adrenomedullin. The receptor activator of nuclear factor‑κB ligand (RANKL)­‑induced osteoclast differentiation was investigated subsequent to treatment with adrenomedullin in vitro. The results demonstrated that adrenomedullin significantly improved bone mass loss, density, bone strength and osteoporosis disease in the mice with glucocorticoid‑induced osteoporosis. In addition, adrenomedullin markedly improved the osteoporosis‑associated NFATc1, TRAP, OSCAR and c‑Fos expression levels. Furthermore, the current findings indicated that RANKL‑­mediated osteoclast differentiation was suppressed in vitro and in vivo. Notably, the data revealed that adrenomedullin significantly improved the osteoporotic symptoms through inhibition of RANKL‑induced NF‑κB activation in glucocorticoid‑induced osteoporosis. In conclusion, adrenomedullin serves an essential role in the progression of glucocorticoid‑induced osteoporosis, regulating the bone mass loss, density and strength through the NF‑κB signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

An G, Acharya C, Feng X, Wen K, Zhong M, Zhang L, Munshi NC, Qiu L, Tai YT and Anderson KC: Osteoclasts promote immune suppressive microenvironment in multiple myeloma: Therapeutic implication. Blood. 128:1590–1603. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Kim TH, Park EK, Huh MI, Kim HK, Kim SY and Lee SH: Rhus javanica gall extract inhibits the differentiation of bone marrow-derived osteoclasts and ovariectomy-induced bone loss. Evid Based Complement Alternat Med. 2016:32847042016. View Article : Google Scholar : PubMed/NCBI

3 

Jeon OH, Panicker LM, Lu Q, Chae JJ, Feldman RA and Elisseeff JH: Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials. Sci Rep. 6:267612016. View Article : Google Scholar : PubMed/NCBI

4 

Paglia DN, Yang X, Kalinowski J, Jastrzebski S, Drissi H and Lorenzo J: Runx1 regulates myeloid precursor differentiation into osteoclasts without affecting differentiation into antigen presenting or phagocytic cells in both males and females. Endocrinology. 157:3058–3069. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Laperine O, Blin-Wakkach C, Guicheux J, Beck-Cormier S and Lesclous P: Dendritic-cell-derived osteoclasts: A new game changer in bone-resorption-associated diseases. Drug Discov Today. 21:1345–1354. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Scott LJ: Denosumab: A review of its use in postmenopausal women with osteoporosis. Drugs Aging. 31:555–576. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Yu S, Liu F, Cheng Z and Wang Q: Association between osteoporosis and benign paroxysmal positional vertigo: A systematic review. BMC Neurol. 14:1102014. View Article : Google Scholar : PubMed/NCBI

8 

Henriksen K, Bollerslev J, Everts V and Karsdal MA: Osteoclast activity and subtypes as a function of physiology and pathology-implications for future treatments of osteoporosis. Endocr Rev. 32:31–63. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ghosh M and Majumdar SR: Antihypertensive medications, bone mineral density and fractures: A review of old cardiac drugs that provides new insights into osteoporosis. Endocrine. 46:397–405. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Iesato Y, Yuda K, Chong KT, Tan X, Murata T, Shindo T and Yanagi Y: Adrenomedullin: A potential therapeutic target for retinochoroidal disease. Prog Retin Eye Res. 52:112–129. 2016. View Article : Google Scholar : PubMed/NCBI

11 

DE LA, Torre-Prados MV, Garcia-DE LA, Torre A, Enguix A, Mayor-Reyes M, Nieto-González M and Garcia-Alcantara A: Mid-regional pro-adrenomedullin as prognostic biomarker in septic shock. Minerva Anestesiol. 82:760–766. 2016.PubMed/NCBI

12 

Hu W, Zhou PH, Rao T, Zhang XB, Wang W and Zhang LJ: Adrenomedullin attenuates interleukin-1β-induced inflammation and apoptosis in rat Leydig cells via inhibition of NF-κB signaling pathway. Exp Cell Res. 339:220–230. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Kim JH, Kim K, Kim I, Seong S, Nam KI, Lee SH, Kim KK and Kim N: Role of CrkII signaling in RANKL-induced osteoclast differentiation and function. J Immunol. 196:1123–1131. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Ito S, Ohmi A, Sakamiya A, Yano T, Okumura K, Nishimura N and Kagontani K: Ginger hexane extract suppresses RANKL-induced osteoclast differentiation. Biosci Biotechnol Biochem. 80:779–785. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Qian H, Yuan H, Wang J, Du Y, Zhang X, Sun Y, Li Z and Zhao W: A monoclonal antibody ameliorates local inflammation and osteoporosis by targeting TNF-α and RANKL. Int Immunopharmacol. 20:370–376. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Lakhan R, Baylink DJ, Lau KH, Tang X, Sheng MH, Rundle CH and Qin X: Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice. Gene Ther. 22:721–728. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Arrabal-Polo MA, Girón-Prieto MS, Cano-García Mdel C, Poyatos-Andujar A, Quesada-Charneco M, Abad-Menor F, Arias-Santiago S, Zuluaga-Gomez A and Arrabal-Martin M: Retrospective review of serum and urinary lithogenic risk factors in patients with osteoporosis and osteopenia. Urology. 85:782–785. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Chiu CK, Kuo MC, Yu SF, Su BY and Cheng TT: Adherence to osteoporosis regimens among men and analysis of risk factors of poor compliance: A 2-year analytical review. BMC Musculoskelet Disord. 14:2762013. View Article : Google Scholar : PubMed/NCBI

19 

Srikanth R, Cassidy G, Joiner C and Teeluckdharry S: Osteoporosis in people with intellectual disabilities: A review and a brief study of risk factors for osteoporosis in a community sample of people with intellectual disabilities. J Intellect Disabil Res. 55:53–62. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Papamanthos M, Varitimidis S, Dailiana Zh, Kogia E and Malizos K: Computer-assisted evaluation of Mandibular Cortical Width (MCW) index as an indicator of osteoporosis. Hippokratia. 18:251–257. 2014.PubMed/NCBI

21 

Schwarz P: Diphosphonate treatment of osteoporosis and risk of atypical femoral fractures. Ugeskr Laeger. 174:302012.(In Danish). PubMed/NCBI

22 

Kushwaha P, Khedgikar V, Ahmad N, Karvande A, Gautam J, Kumar P, Maurya R and Trivedi R: A neoflavonoid dalsissooal isolated from heartwood of Dalbergia sissoo Roxb. Has bone forming effects in mice model for osteoporosis. Eur J Pharmacol. 788:65–74. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Shum LC, White NS, Nadtochiy SM, Bentley KL, Brookes PS, Jonason JH and Eliseev RA: Cyclophilin D Knock-Out mice show enhanced resistance to osteoporosis and to metabolic changes observed in aging bone. PLoS One. 11:e01557092016. View Article : Google Scholar : PubMed/NCBI

24 

Penolazzi L, Lolli A, Sardelli L, Angelozzi M, Lambertini E, Trombelli L, Ciarpella F, Vecchiatini R and Piva R: Establishment of a 3D-dynamic osteoblasts-osteoclasts co-culture model to simulate the jawbone microenvironment in vitro. Life Sci. 152:82–93. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Baltacioglu E, Kehribar MA, Yuva P, Alver A, Atagün OS, Karabulut E and Akalın FA: Total oxidant status and bone resorption biomarkers in serum and gingival crevicular fluid of patients with periodontitis. J Periodontol. 85:317–326. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Ishihara A, Helbig HJ, Sanchez-Hodge RB, Wellman ML, Landrigan MD and Bertone AL: Performance of a gravitational marrow separator, multidirectional bone marrow aspiration needle, and repeated bone marrow collections on the production of concentrated bone marrow and separation of mesenchymal stem cells in horses. Am J Vet Res 74: 854–863, 2013. Am J Vet Res. 74:854–863. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Xiao S, Wang J and Xiao N: MicroRNAs as noninvasive biomarkers in bladder cancer detection: A diagnostic meta-analysis based on qRT-PCR data. Int J Biol Markers. 31:e276–e285. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Lisi S, Sisto M, Lofrumento DD and D'Amore M: Sjögren's syndrome autoantibodies provoke changes in gene expression profiles of inflammatory cytokines triggering a pathway involving TACE/NF-κB. Lab Invest. 92:615–624. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Shiraishi T, Fukuda K, Morotomi N, Imamura Y, Mishima J, Imai S, Miyazawa K and Taniguchi H: Influence of menstruation on the microbiota of healthy women's labia minora as analyzed using a 16S rRNA gene-based clone library method. Jpn J Infect Dis. 64:76–80. 2011.PubMed/NCBI

30 

Wai-Hoe L, Wing-Seng L, Ismail Z and Lay-Harn G: SDS-PAGE-based quantitative assay for screening of kidney stone disease. Biol Proced Online. 11:145–160. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Pengjam Y, Madhyastha H, Madhyastha R, Yamaguchi Y, Nakajima Y and Maruyama M: NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells. Phytomedicine. 23:417–428. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Kwak HB, Lee BK, Oh J, Yeon JT, Choi SW, Cho HJ, Lee MS, Kim JJ, Bae JM, Kim SH and Kim HS: Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression. Bone. 46:724–731. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Lee CH, Kwak SC, Kim JY, Oh HM, Rho MC, Yoon KH, Yoo WH, Lee MS and Oh J: Genipin inhibits RANKL-induced osteoclast differentiation through proteasome-mediated degradation of c-Fos protein and suppression of NF-κB activation. J Pharmacol Sci. 124:344–353. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Lee EG, Sung MS, Yoo HG, Chae HJ, Kim HR and Yoo WH: Increased RANKL-mediated osteoclastogenesis by interleukin-1β and endoplasmic reticulum stress. Joint Bone Spine. 81:520–526. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Lee SY, Lee KS, Yi SH, Kook SH and Lee JC: Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-κB pathway and attenuating ROS production. PLoS One. 8:e808732013. View Article : Google Scholar : PubMed/NCBI

36 

Yun HJ, Lee EG, Lee SI, Chae HJ and Yoo WH: Adrenomedullin inhibits MAPK pathway-dependent rheumatoid synovial fibroblast-mediated osteoclastogenesis by IL-1 and TNF-alpha. Rheumatol Int. 29:1161–1168. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Martinez-Herrero S, Larrayoz IM, Ochoa-Callejero L, Fernández LJ, Allueva A, Ochoa I and Martínez A: Prevention of bone loss in a model of postmenopausal osteoporosis through adrenomedullin inhibition. Front Physiol. 7:2802016. View Article : Google Scholar : PubMed/NCBI

38 

Lin J, Lu C and Gao L: Study on the level of plasma calcitonin gene-related peptide and adrenomedullin in subjects with primary osteoporosis. Zhonghua Yi Xue Za Zhi. 81:841–843. 2001.(In Chinese). PubMed/NCBI

39 

Prause M, Seeliger C, Unger M, Balmayor Rosado E, van Griensven M and Haug AT: Pantoprazole decreases cell viability and function of human osteoclasts in vitro. Mediators Inflamm. 2015:4130972015. View Article : Google Scholar : PubMed/NCBI

40 

Touaitahuata H, Cres G, de Rossi S, Vives V and Blangy A: The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth. Dev Biol. 393:57–70. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Wu C, Zhang J and Tian J: Research progress of osteoclasts function beyond bone resorption. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 29:1038–1042. 2015.(In Chinese). PubMed/NCBI

42 

Yang C, Madhu V, Thomas C, Yang X, Du X, Dighe AS and Cui Q: Inhibition of differentiation and function of osteoclasts by dimethyl sulfoxide (DMSO). Cell Tissue Res. 362:577–585. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Takami M: Differentiation and function of osteoclasts. Nihon Rinsho. 69:1170–1173. 2011.(In Japanese). PubMed/NCBI

44 

Reyes JP, Sims SM and Dixon SJ: P2 receptor expression, signaling and function in osteoclasts. Front Biosci (Schol Ed). 3:1101–1118. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Agrawal A, Buckley KA, Bowers K, Furber M, Gallagher JA and Gartland A: The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro. Purinergic Signal. 6:307–315. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Li H, Hong S, Qian J, Zheng Y, Yang J and Yi Q: Cross talk between the bone and immune systems: Osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells. Blood. 116:210–217. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Imai Y, Youn MY, Kondoh S, Nakamura T, Kouzmenko A, Matsumoto T, Takada I, Takaoka K and Kato S: Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclasts. Ann N Y Acad Sci. 1173 Suppl 1:E31–E39. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Witten PE and Huysseune A: A comparative view on mechanisms and functions of skeletal remodelling in teleost fish, with special emphasis on osteoclasts and their function. Biol Rev Camb Philos Soc. 84:315–346. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Dai X, Ma W, Jha RK and He X: Adrenomedullin and its expression in cancers and bone. A literature review. Front Biosci (Elite Ed). 2:1073–1080. 2010.PubMed/NCBI

50 

Iwase T, Nagaya N, Fujii T, Itoh T, Ishibashi-Ueda H, Yamagishi M, Miyatake K, Matsumoto T, Kitamura S and Kangawa K: Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia. Circulation. 111:356–362. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Pleguezuelos O, Hagi-Pavli E, Crowther G and Kapas S: Adrenomedullin signals through NF-kappaB in epithelial cells. FEBS Lett. 577:249–254. 2004. View Article : Google Scholar : PubMed/NCBI

52 

Yang J, Wang W, Dong M, Yu X and Luo Q: Effect of nucleoprotein factor-kB (NF-κB) in endothelial cells during high blood flow-associated pulmonary vascular remodeling on vasoactive substances adrenomedullin and prostacyclin. Int J Clin Exp Med. 8:13842–13847. 2015.PubMed/NCBI

53 

Lee CH, Jeon YT, Kim SH and Song YS: NF-kappaB as a potential molecular target for cancer therapy. Biofactors. 29:19–35. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Zuo G, Meng X, Gao X, Zhang L and Tang P: Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis. Exp Ther Med 14: 4009-4016, 2017.
APA
Liu, Y., Zuo, G., Meng, X., Gao, X., Zhang, L., & Tang, P. (2017). Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis. Experimental and Therapeutic Medicine, 14, 4009-4016. https://doi.org/10.3892/etm.2017.5025
MLA
Liu, Y., Zuo, G., Meng, X., Gao, X., Zhang, L., Tang, P."Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis". Experimental and Therapeutic Medicine 14.5 (2017): 4009-4016.
Chicago
Liu, Y., Zuo, G., Meng, X., Gao, X., Zhang, L., Tang, P."Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4009-4016. https://doi.org/10.3892/etm.2017.5025
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Zuo G, Meng X, Gao X, Zhang L and Tang P: Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis. Exp Ther Med 14: 4009-4016, 2017.
APA
Liu, Y., Zuo, G., Meng, X., Gao, X., Zhang, L., & Tang, P. (2017). Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis. Experimental and Therapeutic Medicine, 14, 4009-4016. https://doi.org/10.3892/etm.2017.5025
MLA
Liu, Y., Zuo, G., Meng, X., Gao, X., Zhang, L., Tang, P."Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis". Experimental and Therapeutic Medicine 14.5 (2017): 4009-4016.
Chicago
Liu, Y., Zuo, G., Meng, X., Gao, X., Zhang, L., Tang, P."Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor‑κB ligand‑induced nuclear factor‑κB activation in glucocorticoid‑induced osteoporosis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4009-4016. https://doi.org/10.3892/etm.2017.5025
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team