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Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide

  • Authors:
    • Qin Liu
    • Tao Yin
    • Guoping Wang
    • Fuchun Guo
    • Yuhong Ou
    • Yi Li
    • Yongsheng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4263-4271
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    Published online on: August 24, 2017
       https://doi.org/10.3892/etm.2017.5028
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Abstract

Thalidomide (THD) exhibits antitumor effects in several types of cancer. However, the failure of THD to inhibit tumor growth has also been observed in a number of murine models in vivo. The mechanism involved in the therapeutic failure of THD remains unclear. The present study demonstrated that, accompanied by growth‑arresting and apoptosis‑inducing effects (P<0.05), THD upregulated vascular endothelial growth factor receptor 1 (VEGFR1) expression levels in CT26 murine colorectal carcinoma cell lines. This in vitro phenomenon was also observed in various other cell lines, including human umbilical vein endothelial cells, SW480, SW620 and HCT116. Reactive oxygen species (ROS) levels were increased compared with those in the untreated control when cells were exposed to THD (P<0.05). Furthermore, results suggested that ROS suppression may have provoked the induction of VEGFR1 expression to some extent. In addition, the results revealed that THD failed to inhibit CT26 tumor growth in vivo and the expression of VEGFR1 protein was elevated by THD treatment compared with the control group in the murine colorectal tumor model (P<0.05). The results of further experiments suggested that VEGFR1 was elevated in response to various stress‑associated situations, including chemotherapy, radiotherapy and thermotherapy, which indicate that it may act as a stress‑associated protein. The present findings provide a foundation for the future study of VEGFR1‑targeted therapy to enhance the efficacy of current therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Yin T, Wang G, Guo F, Ou Y, Li Y and Wang Y: Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide. Exp Ther Med 14: 4263-4271, 2017.
APA
Liu, Q., Yin, T., Wang, G., Guo, F., Ou, Y., Li, Y., & Wang, Y. (2017). Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide. Experimental and Therapeutic Medicine, 14, 4263-4271. https://doi.org/10.3892/etm.2017.5028
MLA
Liu, Q., Yin, T., Wang, G., Guo, F., Ou, Y., Li, Y., Wang, Y."Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide". Experimental and Therapeutic Medicine 14.5 (2017): 4263-4271.
Chicago
Liu, Q., Yin, T., Wang, G., Guo, F., Ou, Y., Li, Y., Wang, Y."Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4263-4271. https://doi.org/10.3892/etm.2017.5028
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Yin T, Wang G, Guo F, Ou Y, Li Y and Wang Y: Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide. Exp Ther Med 14: 4263-4271, 2017.
APA
Liu, Q., Yin, T., Wang, G., Guo, F., Ou, Y., Li, Y., & Wang, Y. (2017). Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide. Experimental and Therapeutic Medicine, 14, 4263-4271. https://doi.org/10.3892/etm.2017.5028
MLA
Liu, Q., Yin, T., Wang, G., Guo, F., Ou, Y., Li, Y., Wang, Y."Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide". Experimental and Therapeutic Medicine 14.5 (2017): 4263-4271.
Chicago
Liu, Q., Yin, T., Wang, G., Guo, F., Ou, Y., Li, Y., Wang, Y."Vascular endothelial growth receptor 1 acts as a stress‑associated protein in the therapeutic response to thalidomide". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4263-4271. https://doi.org/10.3892/etm.2017.5028
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