Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase‑3, cyclooxygenase‑2 and inducible nitric oxide synthase expression

  • Authors:
    • Zhuanghui Zhu
    • Shuanglian Yi
    • Zhonggui Shan
    • Hongwei Guo
    • Shaofan Ke
  • View Affiliations

  • Published online on: August 25, 2017     https://doi.org/10.3892/etm.2017.5029
  • Pages: 4377-4382
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Abstract

The aim of this study was to evaluate the effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin T (cTnT). A total of 60 patients were randomized into two groups: isoflurane + N2O inhalation (n=30) and propofol + fentanyl anesthesia (n=30). The findings demonstrated that there was no significant difference between the two experimental groups in terms of cTnT levels, demographic properties or hemodynamic parameters. Isoflurane + N2O inhalation and propofol + fentanyl anesthesia, respectively, were also investigated in a rat model of myocardial infarction. Myocardial cell damage, inflammation and oxidative stress levels, caspase‑3/9 activities and cyclooxygenase‑2 protein expression were markedly decreased, although there was no statistical significance difference between the two experimental groups. Notably, inducible nitric oxide synthase protein expression in the isoflurane + N2O inhalation group was significantly higher than that of the propofol + fentanyl anesthesia group (P<0.01). In conclusion, isoflurane + N2O inhalation and propofol + fentanyl anesthesia are not associated with risks for myocardial function.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhu Z, Yi S, Shan Z, Guo H and Ke S: Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase‑3, cyclooxygenase‑2 and inducible nitric oxide synthase expression. Exp Ther Med 14: 4377-4382, 2017
APA
Zhu, Z., Yi, S., Shan, Z., Guo, H., & Ke, S. (2017). Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase‑3, cyclooxygenase‑2 and inducible nitric oxide synthase expression. Experimental and Therapeutic Medicine, 14, 4377-4382. https://doi.org/10.3892/etm.2017.5029
MLA
Zhu, Z., Yi, S., Shan, Z., Guo, H., Ke, S."Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase‑3, cyclooxygenase‑2 and inducible nitric oxide synthase expression". Experimental and Therapeutic Medicine 14.5 (2017): 4377-4382.
Chicago
Zhu, Z., Yi, S., Shan, Z., Guo, H., Ke, S."Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase‑3, cyclooxygenase‑2 and inducible nitric oxide synthase expression". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4377-4382. https://doi.org/10.3892/etm.2017.5029