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Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study

  • Authors:
    • Liang‑Zhu Jiang
    • Wei Jiang
    • Shi‑Yan Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250000, P.R. China, Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Pediatrics, The People's Hospital of Linyi, Linyi, Shandong 276000, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4238-4244
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    Published online on: August 25, 2017
       https://doi.org/10.3892/etm.2017.5031
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Abstract

The aim of the present study was to compare the clinical outcomes of conventional corneal collagen cross‑linking (CXL) and pulsed‑light accelerated CXL (pl‑ACXL) in the eyes of patients with progressive keratoconus. A total of 72 eyes with progressive keratoconus in 58 patients were equally divided into the CXL and pl‑ACXL treatment groups. The CXL treatment was performed using the UVX 1000 system with 0.1% riboflavin solution in 20% dextran presoak for 30 min, and 3 mW/cm2 ultraviolet A (UVA) light for 30 min. The pl‑ACXL group was treated with the KXL system using 0.1% riboflavin with HPMC presoak for 10 min, followed by 8 min (1 sec on/1 sec off) of 30 mW/cm2 UVA light. Patients were evaluated according to the uncorrected distance visual acuity (UDVA), corrected DVA (CDVA), refraction, maximum keratometry (Kmax), endothelial cell density (ECD), anterior segment optical coherence tomography and in vivo confocal microscopy. The follow‑up period was 12 months. Transient haze was observed in 17 eyes (47.22%) in the CXL group and 8 eyes (22.22%) in the pl‑ACXL group at 1 month postoperatively. There were no significant postoperative differences in the astigmatism, manifest refraction spherical equivalent, ECD or thinnest corneal thickness. By contrast, UDVA, CDVA and Kmax presented significant improvement at 12 months postoperatively in the two groups. The demarcation line depth was 284.94±33.29 µm in the CXL group, which was significantly deeper in comparison with that in the pl‑ACXL group (201.64±27.72 µm; P<0.01) at 1 month postoperatively. In vivo confocal microscopy revealed keratocyte apoptosis and stromal edema at 1 month postoperatively, which gradually recovered towards the normal status after 12 months in the two groups. There were no apparent changes in the posterior stroma and endothelium in either group. The results of the present study revealed that CXL and pl‑ACXL were safe and effective procedures in stabilizing the progression of keratoconus. The CXL technique offers more effective visual and topographic outcomes compared with pl‑ACXL, while pl‑ACXL ensures shorter treatment time and reduced microstructural damage.
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1 

Edrington TB, Zadnik K and Barr JT: Keratoconus. Optom Clin. 4:65–73. 2004.

2 

Leccisotti A, Aslanides IM, Moore JE and Shah S: Keratoconus and Keratoectasia: Advancements in diagnosis and treatment. J Ophthalmol. 2012:5260582012. View Article : Google Scholar : PubMed/NCBI

3 

Georgiou T, Funnell CL, Cassels-Brown A and O'Conor R: Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients. Eye. 18:379–383. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Meek KM, Tuft SJ, Huang Y, Gill PS, Hayes S, Newton RH and Bron AJ: Changes in collagen orientation and distribution in keratoconus corneas. Invest Ophthalmol Vis Sci. 46:1948–1956. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Roberts CJ and Dupps WJ Jr: Biomechanics of corneal ectasia and biomechanical treatments. J Cataract Refract Surg. 40:991–998. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Wittig-Silva C, Chan E, Islam FM, Wu T, Whiting M and Snibson GR: A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: Three-year results. Ophthalmology. 121:812–821. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Meiri Z, Keren S, Rosenblatt A, Sarig T, Shenhav L and Varssano D: Efficacy of corneal collagen cross-linking for the treatment of keratoconus: A systematic review and meta-analysis. Cornea. 35:2016. View Article : Google Scholar : PubMed/NCBI

8 

Kling S, Remon L, Pérez-Escudero A, Merayo-Lloves J and Marcos S: Corneal biomechanical changes after collagen cross-linking from porcine eye inflation experiments. Invest Ophthalmol Vis Sci. 51:3961–3968. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Wollensak G, Spoerl E and Seiler T: Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg. 29:1780–1785. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Spoerl E, Wollensak G and Seiler T: Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res. 29:35–40. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Raiskup-Wolf F, Hoyer A, Spoerl E and Pillunat LE: Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: Long-term results. J Cataract Refract Surg. 34:796–801. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Hersh PS, Greenstein SA and Fry KL: Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results. J Cataract Refract Surg. 37:149–160. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Hashemi H, Seyedian MA, Miraftab M, Fotouhi A and Asgari S: Corneal collagen cross-linking with riboflavin and ultraviolet a irradiation for keratoconus: Long-term results. Ophthalmology. 120:1515–1520. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Spoerl E, Mrochen M, Sliney D, Trokel S and Seiler T: Safety of UVA-riboflavin cross-linking of the cornea. Cornea. 26:385–389. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Wernli J, Schumacher S, Spoerl E and Mrochen M: The efficacy of corneal cross-linking shows a sudden decrease with very high intensity UV light and short treatment time. Invest Ophthalmol Vis Sci. 54:1176–1180. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Mrochen M: Current status of accelerated corneal cross-linking. Indian J Ophthalmol. 61:428–429. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Kurt T, Ozgurhan EB, Yildirim Y, Akcay BI, Cosar MG, Bozkurt E and Taskapili M: Accelerated (18 mW/cm(2)) corneal cross-linking for progressive keratoconus: 18-Month results. J Ocul Pharmacol Ther. 32:186–191. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Richoz O, Hammer A, Tabibian D, Gatzioufas Z and Hafezi F: The Biomechanical effect of corneal collagen cross-linking (CXL) with riboflavin and UV-A is oxygen dependent. Transl Vis Sci Technol. 2:62013. View Article : Google Scholar : PubMed/NCBI

19 

Hammer A, Richoz O, Mosquera Arba S, Tabibian D, Hoogewoud F and Hafezi F: Corneal biomechanical properties at different corneal cross-linking (CXL) irradiances. Invest Ophthalmol Vis Sci. 55:2881–2884. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Peyman A, Nouralishahi A, Hafezi F, Kling S and Peyman M: Stromal demarcation line in pulsed versus continuous light accelerated corneal cross-linking for keratoconus. J Refract Surg. 32:206–208. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Kamiya K, Ishii R, Shimizu K and Igarashi A: Evaluation of corneal elevation, pachymetry and keratometry in keratoconic eyes with respect to the stage of Amsler-Krumeich classification. Br J Ophthalmol. 98:459–463. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Krumeich JH and Kezirian GM: Circular keratotomy to reduce astigmatism and improve vision in stage I and II keratoconus. J Refract Surg. 25:357–365. 2009. View Article : Google Scholar : PubMed/NCBI

23 

O'Brart DP, Chan E, Samaras K, Patel P and Shah SP: A randomised, prospective study to investigate the efficacy of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linkage to halt the progression of keratoconus. Br J Ophthalmol. 95:1519–1524. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Konstantopoulos A and Mehta JS: Conventional versus accelerated collagen cross-linking for keratoconus. Eye Contact Lens. 41:65–71. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Razmjoo H, Rahimi B, Kharraji M, Koosha N and Peyman A: Corneal haze and visual outcome after collagen crosslinking for keratoconus: A comparison between total epithelium off and partial epithelial removal methods. Adv Biomed Res. 3:2212014. View Article : Google Scholar : PubMed/NCBI

26 

Salomão MQ, Chaurasia SS, Sinha-Roy A, Ambrósio R Jr, Esposito A, Sepulveda R, Agrawal V and Wilson SE: Corneal wound healing after ultraviolet-A/riboflavin collagen cross-linking: a rabbit study. J Refract Surg. 27:401–407. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Kymionis GD, Portaliou DM, Diakonis VF, Kontadakis GA, Krasia MS, Papadiamantis AG, Coskunseven E and Pallikaris AI: Posterior linear stromal haze formation after simultaneous photorefractive keratectomy followed by corneal collagen cross-linking. Invest Ophthalmol Vis Sci. 51:5030–5033. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Waszczykowska A and Jurowski P: Two-year accelerated corneal cross-linking outcome in patients with progressive keratoconus. Biomed Res Int. 2015:3251572015. View Article : Google Scholar : PubMed/NCBI

29 

Caporossi A, Mazzotta C, Baiocchi S and Caporossi T: Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: The Siena eye cross study. Am J Ophthalmol. 149:585–593. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Mazzotta C, Traversi C, Paradiso AL, Latronico ME and Rechichi M: Pulsed light accelerated crosslinking versus continuous light accelerated crosslinking: One-year results. J Ophthalmol. 2014:6047312014. View Article : Google Scholar : PubMed/NCBI

31 

Beshtawi IM, Akhtar R, Hillarby MC, O'Donnell C, Zhao X, Brahma A, Carley F, Derby B and Radhakrishnan H: Biomechanical properties of human corneas following low- and high-intensity collagen cross-linking determined with scanning acoustic microscopy. Invest Ophthalmol Vis Sci. 54:5273–5280. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Seiler T and Hafezi F: Corneal cross-linking-induced stromal demarcation line. Cornea. 25:1057–1059. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Kohlhaas M, Spoerl E, Schilde T, Unger G, Wittig C and Pillunat LE: Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg. 32:279–283. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Vinciguerra P, Camesasca FI, Albè E and Trazza S: Corneal collagen cross-linking for ectasia after excimer laser refractive surgery: 1-year results. J Refract Surg. 26:486–497. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C and Caporossi A: Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: Ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea. 26:390–397. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Jordan C, Patel DV, Abeysekera N and Mcghee CN: In vivo confocal microscopy analyses of corneal microstructural changes in a prospective study of collagen cross-linking in keratoconus. Ophthalmology. 121:469–474. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Ku JY, Niederer RL, Patel DV, Sherwin T and Mcghee CN: Laser scanning in vivo confocal analysis of keratocyte density in keratoconus. Ophthalmology. 115:845–850. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Messmer EM, Meyer P, Herwig MC, Loeffler KU, Schirra F, Seitz B, Thiel M, Reinhard T, Kampik A and Auw-Haedrich C: Morphological and immunohistochemical changes after corneal cross-linking. Cornea. 32:111–117. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang LZ, Jiang W and Qiu SY: Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study. Exp Ther Med 14: 4238-4244, 2017.
APA
Jiang, L., Jiang, W., & Qiu, S. (2017). Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study. Experimental and Therapeutic Medicine, 14, 4238-4244. https://doi.org/10.3892/etm.2017.5031
MLA
Jiang, L., Jiang, W., Qiu, S."Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study". Experimental and Therapeutic Medicine 14.5 (2017): 4238-4244.
Chicago
Jiang, L., Jiang, W., Qiu, S."Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4238-4244. https://doi.org/10.3892/etm.2017.5031
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang LZ, Jiang W and Qiu SY: Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study. Exp Ther Med 14: 4238-4244, 2017.
APA
Jiang, L., Jiang, W., & Qiu, S. (2017). Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study. Experimental and Therapeutic Medicine, 14, 4238-4244. https://doi.org/10.3892/etm.2017.5031
MLA
Jiang, L., Jiang, W., Qiu, S."Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study". Experimental and Therapeutic Medicine 14.5 (2017): 4238-4244.
Chicago
Jiang, L., Jiang, W., Qiu, S."Conventional vs. pulsed‑light accelerated corneal collagen cross‑linking for the treatment of progressive keratoconus: 12‑month results from a prospective study". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4238-4244. https://doi.org/10.3892/etm.2017.5031
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