Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis

  • Authors:
    • Miaoyun Wen
    • Zhesi Lian
    • Linqiang Huang
    • Senzhi Zhu
    • Bei Hu
    • Yongli Han
    • Yiyu Deng
    • Hongke Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Emergency and Critical Care Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China, Tufts University School of Medicine, Boston, MA 02111, USA, Department of Acute Critical Care Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4118-4124
    |
    Published online on: August 25, 2017
       https://doi.org/10.3892/etm.2017.5034
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The diagnostic value of magnetic resonance spectroscopy (MRS), T2-weighted imaging (T2WI) and serum markers of brain injury in a rat model of sepsis were investigated. Rats were randomly divided into the control group and 6, 12 and 24 h after lipopolysaccharide-injection groups. Brain morphology and metabolism were assessed with T2WI magnetic resonance imaging (MRI) and MRS. Serum and brain tissue samples were then collected to examine the concentrations of neuron‑specific enolase (NSE) and S100-β protein. Brain T2WI showed no differences between the groups. N-acetylaspartate/choline (NAA/Cr) ratio measured by MRS showed different degrees of decrease in the sepsis groups, and serum NSE and S100-β concentrations were increased compared with the control group. Apoptosis rates were measured in the right hippocampal area, and there were statistically significant differences between the indicated groups and the control group (p<0.05). The correlation between apoptosis rate and NAA/Cr ratio was closer than that between apoptosis rate and NSE or S100-β (-0.925 vs. 0.434 vs. 0.517, respectively). In conclusion, MRS is a sensitive, non-invasive method to investigate complications of brain injury in septic rats, which may be utilized for the early diagnosis of brain injury caused by sepsis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Cotena S and Piazza O: Sepsis-associated encephalopathy. Transl Med UniSa. 2:20–27. 2012.PubMed/NCBI

2 

Young GB, Bolton CF, Austin TW, Archibald YM, Gonder J and Wells GA: The encephalopathy associated with septic illness. Clin Invest Med. 13:297–304. 1990.PubMed/NCBI

3 

Salluh JI, Soares M, Teles JM, Ceraso D, Raimondi N, Nava VS, Blasquez P, Ugarte S, Ibanez-Guzman C, Centeno JV, et al: Delirium Epidemiology in Critical Care Study Group: Delirium epidemiology in critical care (DECCA): an international study. Crit Care. 14:R2102010. View Article : Google Scholar : PubMed/NCBI

4 

Zampieri FG, Park M, Machado FS and Azevedo LC: Sepsis-associated encephalopathy: not just delirium. Clinics (Sao Paulo). 66:1825–1831. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Pytel P and Alexander JJ: Pathogenesis of septic encephalopathy. Curr Opin Neurol. 22:283–287. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Rodríguez-Núñez A, Cid E, Rodríguez-García J, Camiña F, Rodríguez-Segade S and Castro-Gago M: Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis. J Child Neurol. 16:704–706. 2001. View Article : Google Scholar : PubMed/NCBI

7 

van den Boogaard M, Ramakers BP, van Alfen N, van der Werf SP, Fick WF, Hoedemaekers CW, Verbeek MM, Schoonhoven L, van der Hoeven JG and Pickkers P: Endotoxemia-induced inflammation and the effect on the human brain. Crit Care. 14:R812010. View Article : Google Scholar : PubMed/NCBI

8 

Piazza O, Russo E, Cotena S, Esposito G and Tufano R: Elevated S100B levels do not correlate with the severity of encephalopathy during sepsis. Br J Anaesth. 99:518–521. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Heizmann CW: S100B protein in clinical diagnostics: assay specificity. Clin Chem. 50:249–251. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Piazza O, Cotena S, De Robertis E, Caranci F and Tufano R: Sepsis associated encephalopathy studied by MRI and cerebral spinal fluid S100B measurement. Neurochem Res. 34:1289–1292. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Lim MK, Suh CH, Kim HJ, Cho YK, Choi SH, Kang JH, Park W and Lee JH: Systemic lupus erythematosus: brain MR imaging and single-voxel hydrogen 1 MR spectroscopy. Radiology. 217:43–49. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Castillo M, Kwock L and Mukherji SK: Clinical applications of proton MR spectroscopy. AJNR Am J Neuroradiol. 17:1–15. 1996.PubMed/NCBI

13 

Cohen BA, Inglese M, Rusinek H, Babb JS, Grossman RI and Gonen O: Proton MR spectroscopy and MRI-volumetry in mild traumatic brain injury. AJNR Am J Neuroradiol. 28:907–913. 2007.PubMed/NCBI

14 

Inder TE and Volpe JJ: Mechanisms of perinatal brain injury. Semin Neonatol. 5:3–16. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Mishra AM, Gupta RK, Jaggi RS, Reddy JS, Jha DK, Husain N, Prasad KN, Behari S and Husain M: Role of diffusion-weighted imaging and in vivo proton magnetic resonance spectroscopy in the differential diagnosis of ring-enhancing intracranial cystic mass lesions. J Comput Assist Tomogr. 28:540–547. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Lin LC, Chen YY, Lee WT, Chen HL and Yang RC: Heat shock pretreatment attenuates sepsis-associated encephalopathy in LPS-induced septic rats. Brain Dev. 32:371–377. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Van Zijl PC and Barker PB: Magnetic resonance spectroscopy and spectroscopic imaging for the study of brain metabolism. Ann N Y Acad Sci. 820:75–96. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Bozza FA, Garteiser P, Oliveira MF, Doblas S, Cranford R, Saunders D, Jones I, Towner RA and Castro-Faria-Neto HC: Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab. 30:440–448. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Messaris E, Memos N, Chatzigianni E, Konstadoulakis MM, Menenakos E, Katsaragakis S, Voumvourakis C and Androulakis G: Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis. Crit Care Med. 32:1764–1770. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Ayala A, Perl M, Venet F, Lomas-Neira J, Swan R and Chung CS: Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets. Curr Pharm Des. 14:1853–1859. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Mouihate A and Pittman QJ: Lipopolysaccharide-induced fever is dissociated from apoptotic cell death in the rat brain. Brain Res. 805:95–103. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Sharshar T, Gray F, de la Grandmaison Lorin G, Hopkinson NS, Ross E, Dorandeu A, Orlikowski D, Raphael JC, Gajdos P and Annane D: Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet. 362:1799–1805. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Davies DC: Blood-brain barrier breakdown in septic encephalopathy and brain tumours. J Anat. 200:639–646. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Orihuela CJ, Fillon S, Smith-Sielicki SH, El Kasmi KC, Gao G, Soulis K, Patil A, Murray PJ and Tuomanen EI: Cell wall-mediated neuronal damage in early sepsis. Infect Immun. 74:3783–3789. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Papadopoulos MC, Lamb FJ, Moss RF, Davies DC, Tighe D and Bennett ED: Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex. Clin Sci (Lond). 96:461–466. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Undén J, Christensson B, Bellner J, Alling C and Romner B: Serum S100B levels in patients with cerebral and extracerebral infectious disease. Scand J Infect Dis. 36:10–13. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wen M, Lian Z, Huang L, Zhu S, Hu B, Han Y, Deng Y and Zeng H: Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis. Exp Ther Med 14: 4118-4124, 2017.
APA
Wen, M., Lian, Z., Huang, L., Zhu, S., Hu, B., Han, Y. ... Zeng, H. (2017). Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis. Experimental and Therapeutic Medicine, 14, 4118-4124. https://doi.org/10.3892/etm.2017.5034
MLA
Wen, M., Lian, Z., Huang, L., Zhu, S., Hu, B., Han, Y., Deng, Y., Zeng, H."Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis". Experimental and Therapeutic Medicine 14.5 (2017): 4118-4124.
Chicago
Wen, M., Lian, Z., Huang, L., Zhu, S., Hu, B., Han, Y., Deng, Y., Zeng, H."Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4118-4124. https://doi.org/10.3892/etm.2017.5034
Copy and paste a formatted citation
x
Spandidos Publications style
Wen M, Lian Z, Huang L, Zhu S, Hu B, Han Y, Deng Y and Zeng H: Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis. Exp Ther Med 14: 4118-4124, 2017.
APA
Wen, M., Lian, Z., Huang, L., Zhu, S., Hu, B., Han, Y. ... Zeng, H. (2017). Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis. Experimental and Therapeutic Medicine, 14, 4118-4124. https://doi.org/10.3892/etm.2017.5034
MLA
Wen, M., Lian, Z., Huang, L., Zhu, S., Hu, B., Han, Y., Deng, Y., Zeng, H."Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis". Experimental and Therapeutic Medicine 14.5 (2017): 4118-4124.
Chicago
Wen, M., Lian, Z., Huang, L., Zhu, S., Hu, B., Han, Y., Deng, Y., Zeng, H."Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4118-4124. https://doi.org/10.3892/etm.2017.5034
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team