Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease

  • Authors:
    • Jianzheng Zhang
    • Juan Wang
    • Xiaowei Wang
    • Zhi Liu
    • Jixin Ren
    • Tiansheng Sun
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Beijing Army General Hospital, Beijing 100700, P.R. China
  • Pages: 4541-4546
    |
    Published online on: August 28, 2017
       https://doi.org/10.3892/etm.2017.5044
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hip fractures are one of the most common injuries in elderly individuals and are associated with a high incidence of complications and mortality. Clinical guidelines recommend early reparative surgery within 24‑48 h from hospital admission; however, it is currently unknown whether this principle of early surgery is applicable for patients with hip fracture and chronic obstructive pulmonary disease (COPD). To investigate the systemic inflammatory response and lung injury as a result early surgery in elderly patients with hip fracture and COPD, a COPD model was created, by daily exposure to cigarette smoke, and evaluated. Rats (5 months of age) were exposed to cigarette smoking for 37 weeks to create a COPD group. Rats not exposed to cigarette smoke formed the control group. All rats experienced hip fracture, which was subsequently treated with surgery at 24 h (early fixation; EF) or 72 h (late fixation; LF) after fracture, respectively. Serum mitochondrial DNA (mtDNA), tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑6 and IL‑10 were measured at 2 and 24 h after surgery. Cytokine and myeloperoxidase (MPO) activity in the lung tissue were measured and assessed via bronchoalveolar lavage. The serum mtDNA, IL‑6 and IL‑10 levels in the control group and in the COPD group increased rapidly at 2 h and peaked at 24 h, while TNF‑α levels peaked at 2 h and subsequently decreased. Rats that received EF in the COPD group demonstrated a significant increase of TNF‑α (P<0.001 at 2 h), IL‑6 (P<0.001 at 2 and 24 h), IL‑10 (P=0.010 at 2 h and P=0.001 at 24 h) and mtDNA (P<0.001 at 24 h) compared with the rats that received LF. LF in experimental rats also significantly reduced the severity of MPO activity (P<0.001 and P=0.001) and permeability (P=0.009 and P=0.018) in pulmonary samples at 2 or 24 h, respectively, compared with EF. However, LF in the control group did not demonstrate a significant advantage at reducing MPO and permeability in serum and pulmonary samples. The present study indicated that early surgery increased mtDNA and cytokine release in a model of elderly hip fracture with COPD, and LF may reduce the severity of the inflammatory response and degree of permeability in pulmonary tissues.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Buecking B, Bohl K, Eschbach D, Bliemel C, Aigner R, Balzer-Geldsetzer M, Dodel R, Ruchholtz S and Debus F: Factors influencing the progress of mobilization in hip fracture patients during the early postsurgical period? A prospective observational study. Arch Gerontol Geriatr. 60:457–463. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Caillet P, Klemm S, Ducher M, Aussem A and Schott AM: Hip fracture in the elderly: A re-analysis of the EPIDOS study with causal Bayesian networks. PLoS One. 10:e01201252015. View Article : Google Scholar : PubMed/NCBI

3 

Cook WL, Schiller C, McAllister MM, Hanson HM, Brasher PM, Donaldson MG, Macri E, Preto R, Guy P and Ashe MC: Feasibility of a follow-up hip fracture clinic. J Am Geriatr Soc. 63:598–599. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Hawkes D, Baxter J, Bailey C, Holland G, Ruddlesdin J, Wall A and Wykes P: Improving the care of patients with a hip fracture: A quality improvement report. BMJ Qual Saf. 24:532–538. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Heyes GJ, Tucker A, Marley D and Foster A: Predictors for 1-year mortality following hip fracture: A retrospective review of 465 consecutive patients. Eur J Trauma Emerg Surg. 43:113–119. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Heyes GJ, Tucker A, Marley D and Foster A: Predictors for readmission up to 1 year following hip fracture. Arch Trauma Res. 4:e271232015.PubMed/NCBI

7 

Boylan MR, Rosenbaum J, Adler A, Naziri Q and Paulino CB: Hip fracture and the weekend effect: Does weekend admission affect patient outcomes? Am J Orthop (Belle Mead NJ). 44:458–464. 2015.PubMed/NCBI

8 

Clague JE, Craddock E, Andrew G, Horan MA and Pendleton N: Predictors of outcome following hip fracture. Admission time predicts length of stay and in-hospital mortality. Injury. 33:1–6. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Lo IL, Siu CW, Tse HF, Lau TW, Leung F and Wong M: Pre-operative pulmonary assessment for patients with hip fracture. Osteoporos Int. 21 Suppl 4:S579–S586. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Vogiatzis I and Zakynthinos S: Factors limiting exercise tolerance in chronic lung diseases. Compr Physiol. 2:1779–1817. 2012.PubMed/NCBI

11 

Sathiyakumar V, Avilucea FR, Whiting PS, Jahangir AA, Mir HR, Obremskey WT and Sethi MK: Risk factors for adverse cardiac events in hip fracture patients: An analysis of NSQIP data. Int Orthop. 40:439–445. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Gan L, Zhong J, Zhang R, Sun T, Li Q, Chen X and Zhang J: The immediate intramedullary nailing surgery increased the mitochondrial DNA release that aggravated systemic inflammatory response and lung injury induced by elderly hip fracture. Mediators Inflamm. 2015:5873782015. View Article : Google Scholar : PubMed/NCBI

13 

Gan L, Chen X, Sun T, Li Q, Zhang R, Zhang J and Zhong J: Significance of serum mtDNA concentration in lung injury induced by hip fracture. Shock. 44:52–57. 2015. View Article : Google Scholar : PubMed/NCBI

14 

McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM and Balogh ZJ: Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery. J Crit Care. 29(1133): e1–e5. 2014.

15 

Tranah GJ, Nalls MA, Katzman SM, Yokoyama JS, Lam ET, Zhao Y, Mooney S, Thomas F, Newman AB, Liu Y, et al: Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly. J Alzheimers Dis. 32:357–372. 2012.PubMed/NCBI

16 

Zhong N, Zhang Y, Zhu HF and Zhou ZN: Intermittent hypoxia exposure prevents mtDNA deletion and mitochondrial structure damage produced by ischemia/reperfusion injury. Sheng Li Xue Bao. 52:375–380. 2000.PubMed/NCBI

17 

Zheng H, Liu Y, Huang T, Fang Z, Li G and He S: Development and characterization of a rat model of chronic obstructive pulmonary disease (COPD) induced by sidestream cigarette smoke. Toxicol Lett. 189:225–234. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Sun T, Wang X, Liu Z, Liu S and Zhang J: Patterns of cytokine release and evolution of remote organs from proximal femur fracture in COPD rats. Injury. 42:825–832. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Chen PX and Moldoveanu SC: Mainstream smoke chemical analyses for 2R4F kentucky reference cigarette. Beiträge Zur Tabakforschung International/Contributions to Tobacco Research. 20:448–458. 2014.

20 

Ellinger J, Müller DC, Müller SC, Hauser S, Heukamp LC, von Ruecker A, Bastian PJ and Walgenbach-Brunagel G: Circulating mitochondrial DNA in serum: A universal diagnostic biomarker for patients with urological malignancies. Urol Oncol. 30:509–515. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Pape HC: Effects of changing strategies of fracture fixation on immunologic changes and systemic complications after multiple trauma: damage control orthopedic surgery. J Orthop Res. 26:1478–1484. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Lin HH, Murray M, Cohen T, Colijn C and Ezzati M: Effects of smoking and solid-fuel use on COPD, lung cancer, and tuberculosis in China: A time-based, multiple risk factor, modelling study. Lancet. 372:1473–1483. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Rossini M, Viapiana O, Adami S, Idolazzi L, Buda S, Veronesi C, Esposti Degli L and Gatti D: Medication use before and after hip fracture: A population-based cohort and case-control study. Drugs Aging. 31:547–553. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Nettleman MD, Alsip J, Schrader M and Schulte M: Predictors of mortality after acute hip fracture. J Gen Intern Med. 11:765–767. 1996. View Article : Google Scholar : PubMed/NCBI

25 

de Luise C, Brimacombe M, Pedersen L and Sørensen HT: Chronic obstructive pulmonary disease and mortality following hip fracture: A population-based cohort study. Eur J Epidemiol. 23:115–122. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Hirose J, Mizuta H, Ide J and Nomura K: Evaluation of estimation of physiologic ability and surgical stress (E-PASS) to predict the postoperative risk for hip fracture in elder patients. Arch Orthop Trauma Surg. 128:1447–1452. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Pape HC, van Griensven M, Rice J, Gänsslen A, Hildebrand F, Zech S, Winny M, Lichtinghagen R and Krettek C: Major secondary surgery in blunt trauma patients and perioperative cytokine liberation: Determination of the clinical relevance of biochemical markers. J Trauma. 50:989–1000. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Pape HC, Grimme K, Van Griensven M, Sott AH, Giannoudis P, Morley J, Roise O, Ellingsen E, Hildebrand F, Wiese B, et al: Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: Prospective randomized analysis by the EPOFF Study Group. J Trauma. 55:7–13. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Scalea TM: Optimal timing of fracture fixation: Have we learned anything in the past 20 years? J Trauma. 65:253–260. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Harwood PJ, Giannoudis PV, van Griensven M, Krettek C and Pape HC: Alterations in the systemic inflammatory response after early total care and damage control procedures for femoral shaft fracture in severely injured patients. J Trauma. 58:446–454. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Zhang JZ, Liu Z, Liu J, Ren JX and Sun TS: Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue. Int J Mol Med. 33:817–824. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Wang J, Wang X, Liu Z, Ren J and Sun T: Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease. Exp Ther Med 14: 4541-4546, 2017.
APA
Zhang, J., Wang, J., Wang, X., Liu, Z., Ren, J., & Sun, T. (2017). Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease. Experimental and Therapeutic Medicine, 14, 4541-4546. https://doi.org/10.3892/etm.2017.5044
MLA
Zhang, J., Wang, J., Wang, X., Liu, Z., Ren, J., Sun, T."Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 14.5 (2017): 4541-4546.
Chicago
Zhang, J., Wang, J., Wang, X., Liu, Z., Ren, J., Sun, T."Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4541-4546. https://doi.org/10.3892/etm.2017.5044
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Wang J, Wang X, Liu Z, Ren J and Sun T: Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease. Exp Ther Med 14: 4541-4546, 2017.
APA
Zhang, J., Wang, J., Wang, X., Liu, Z., Ren, J., & Sun, T. (2017). Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease. Experimental and Therapeutic Medicine, 14, 4541-4546. https://doi.org/10.3892/etm.2017.5044
MLA
Zhang, J., Wang, J., Wang, X., Liu, Z., Ren, J., Sun, T."Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 14.5 (2017): 4541-4546.
Chicago
Zhang, J., Wang, J., Wang, X., Liu, Z., Ren, J., Sun, T."Early surgery increases mitochondrial DNA release and lung injury in a model of elderly hip fracture and chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4541-4546. https://doi.org/10.3892/etm.2017.5044
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team