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Article

Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study

  • Authors:
    • Yoko Sawada
    • Atsushi Sugimoto
    • Takehito Hananouchi
    • Norimasa Sato
    • Isao Nagaoka
  • View Affiliations / Copyright

    Affiliations: Technology Research and Development Laboratory, Research and Development Headquarters, Asahi Group Foods, Ltd., Moriya, Ibaraki 302‑0106, Japan, Medical Engineering Laboratory, Department of Mechanical Engineering, Faculty of Engineering, Osaka Sangyo University, Osaka 574‑8530, Japan, Umeda Oak Clinic, Osaka 530‑0057, Japan, Department of Host Defense and Biochemical Research, Graduate School of Medicine, Juntendo University, Tokyo 113‑8421, Japan
  • Pages: 4561-4571
    |
    Published online on: August 29, 2017
       https://doi.org/10.3892/etm.2017.5064
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Abstract

The aim of the present study was to assess the efficacy and safety of the oral administration of Ajuga decumbens extract (ADE) supplement to individuals with knee discomfort associated with physical activity. A randomized, double‑blind, placebo‑controlled study was conducted using 48 subjects. The subjects were randomly allocated to an ADE diet group (oral administration of ADE‑containing diet, n=24) or a placebo group (n=24), and the intervention was conducted for 12 weeks. A total of 22 subjects in the placebo group and 22 subjects in the ADE diet group were assessed to be eligible for assessment of the efficacy of supplement. Knee function was assessed by changes in the scores of the Japanese Knee Osteoarthritis Measure (JKOM) questionnaire and the scores of the Japan Orthopedic Association (JOA) criteria, as well as by analyzing the levels of type II collagen synthesis and degradation biomarkers (procollagen II C‑terminal propeptide, cross‑linked C‑telopeptide of type II collagen, collagen type II cleavage and matrix metalloproteinase‑13). Outcomes were measured at the baseline and at 4, 8 and 12 weeks from the start of administration. Subscale II (joint flexion/stiffness) of the JOA criteria was markedly improved in the ADE diet group compared with the placebo group at 8 and 12 weeks during the intervention. Furthermore, in the subgroup analyses using subjects with mild knee discomfort, subscale II (pain/stiffness) and IV (general activities) scores of JKOM were significantly improved (P<0.05) and total JKOM score was markedly improved in the ADE diet group compared with the placebo group at week 8 of the intervention. No adverse effects were identified for the administration of ADE. In conclusion, these observations suggest that the administration of an ADE‑containing diet is safe and improves joint function (flexion and stiffness) and general activity in subjects with mild knee discomfort. Therefore, ADE could be a promising candidate as a functional food that is beneficial to joint health.
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1 

Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, et al: Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: The research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab. 27:620–628. 2009. View Article : Google Scholar : PubMed/NCBI

2 

McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, et al: OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 22:363–388. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Xu G and Wang Q: Practical Illustrations of Chinese Materia Medica. Fujian Science & Technology Publishing House; Fuzhou: pp. 92–93. 2006

4 

Ou M: Chinese-English Manual of Common-Used in Traditional Chinese Medicine. Joint Publishing (Hong Kong) Co., Ltd.; Hong Kong: pp. 164–165. 1989

5 

Rashad S, Low F, Revell P, Hemingway A, Rainsford K and Walker F: Effect of non-steroidal anti-inflammatory drugs on course of osteoarthritis. Lancet. 2:11491989. View Article : Google Scholar : PubMed/NCBI

6 

Herman JH and Hess EV: Nonsteroidal anti-inflammatory drugs and modulation of cartilaginous changes in osteoarthritis and rheumatoid arthritis. Clinical implications. Am J Med. 77:16–25. 1984. View Article : Google Scholar : PubMed/NCBI

7 

Ono Y, Fukaya Y, Imai S and Yamakuni T: Beneficial effects of Ajuga decumbens on osteoporosis and arthritis. Biol Pharm Bull. 31:1199–1204. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Sawada Y, Sugimoto A, Fukuda K, Osaki T and Minami S: Oral administration of Ajuga decumbens extract has a synergetic effect with glucosamine on cartilaginous injury in a rabbit osteoarthritis model. J Chitin Chitosan Sci. 2:191–196. 2014. View Article : Google Scholar

9 

Akai M, Iwaya T, Kurosawa H, Doi T, Nasu T, Hyashi K and Fujino K; JKOM (Japanese Knee Osteoarthritis Measure), : Development of new disease-specific QOL measure for patients with knee osteoarthritis: Japanese Knee Osteoarthritis Measure (JKOM). J Physical Medicine. 16:55–62. 2005.(In Japanese).

10 

Akai M, Doi T, Fujino K, Iwaya T, Kurosawa H and Nasu T: An outcome measure for Japanese people with knee osteoarthritis. J Rheumatol. 32:1524–1532. 2005.PubMed/NCBI

11 

Koshino T and Niwa J: Assessment criteria for knee diseases and treatments. J Jpn Orthop Assoc. 62:900–904. 1988.(In Japanese).

12 

Kellgren JH and Lawrence JS: Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 16:494–502. 1957. View Article : Google Scholar : PubMed/NCBI

13 

Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, et al: Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: The ROAD study. Osteoarthritis Cartilage. 17:1137–1143. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Reijman M, Hazes JM, Bierma-Zeinstra SM, Koes BW, Christgau S, Christiansen C, Uitterlinden AG and Pols HA: A new marker for osteoarthritis: Cross-sectional and longitudinal approach. Arthritis Rheum. 50:2471–2478. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Poole AR, Ionescu M, Fitzcharles MA and Billinghurst RC: The assessment of cartilage degradation in vivo: Development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases. J Immunol Methods. 294:145–153. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Nelson F, Dahlberg L, Laverty S, Reiner A, Pidoux I, Ionescu M, Fraser GL, Brooks E, Tanzer M, Rosenberg LC, et al: Evidence for altered synthesis of type II collagen in patients with osteoarthritis. J Clin Invest. 102:2115–2125. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Wang S, Wei X, Zhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB, Ehrlich MG, et al: Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis. Arthritis Rheum. 66:1843–1853. 2014. View Article : Google Scholar

18 

Poole AR, Nelson F, Dahlberg L, Tchetina E, Kobayashi M, Yasuda T, Laverty S, Squires G, Kojima T, Wu W and Billinghurst RC: Proteolysis of the collagen fibril in osteoarthritis. Biochem Soc Symp. 115–123. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Braham R, Dawson B and Goodman C: The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med. 37:45–49. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Nagaoka I, Suzuki A, Kurokawa M, Tamonaga A, Fukagawa M, Watanabe K and Yamamoto T: Effect of a dietary supplement containing collagen peptide on symptoms and biomarkeres in individuals with knee pain. Glucosamine Res. 9:40–47. 2013.(In Japanese).

21 

Watanabe H, Urabe K, Kamiya K, Hamazaki N, Miida K, Suda K, Hendona T, Fujita M, Aikawa J, Itoman M and Futami T: Relationship between quality of life using the Japan Knee Osteoarthritis Measure (JKOM) and physical function in patients with osteoarthritis of the knee. Jpn Physical Therapy Association. 34:67–73. 2007.(In Japanese).

22 

Watanabe H, Urabe K, Takahira N, Ikeda N, Fujita M, Obara S, Hendona T, Aikawa J and Itoman M: Quality of life, knee function, and physical activity in Japanese elderly women with early-stage knee osteoarthritis. J Orthop Surg (Hong Kong). 18:31–34. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Nozaki H, Takezawa Y, Suguro T, Igata L, Kudo Y and Motegi M: MRI of articular cartilaginous lesions: MRI findings in osteoarthritis of the knee joint. Jpn j rheum and joint surg. 13:341–352. 1994.

24 

Garnero P and Delmas PD: Biomarkers in osteoarthritis. Curr Opin Rheumatol. 15:641–646. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Christgau S, Henrotin Y, Tankó LB, Rovati LC, Collette J, Bruyere O, Deroisy R and Reginster JY: Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate. Clin Exp Rheumatol. 22:36–42. 2004.PubMed/NCBI

26 

Cibere J, Thorne A, Kopec JA, Singer J, Canvin J, Robinson DB, Pope J, Hong P, Grant E, Lobanok T, et al: Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: Randomized discontinuation trial results employing biomarkers. J Rheumatol. 32:896–902. 2005.PubMed/NCBI

27 

Mazieres B, Hucher M, Zaïm M and Garnero P: Effect of chondroitin sulphate in symptomatic knee osteoarthritis: A multicentre, randomised, double-blind, placebo-controlled study. Ann Rheum Dis. 66:639–645. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Yoshimura M, Sakamoto K, Tsuruta A, Yamamoto T, Ishida K, Yamaguchi H and Nagaoka I: Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. Int J Mol Med. 24:487–494. 2009.PubMed/NCBI

29 

Momomura R, Naito K, Igarashi M, Watari T, Terakado A, Oike S, Sakamoto K, Nagaoka I and Kaneko K: Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers. Mol Med Rep. 7:742–746. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Nagaoka I: Recent Aspects of the chondroprotective and anti-inflammatory actions of glucosamine, a functional food. Juntendo Med J. 60:580–587. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Sawada Y, Sugimoto A, Hananouchi T, Sato N and Nagaoka I: Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study. Exp Ther Med 14: 4561-4571, 2017.
APA
Sawada, Y., Sugimoto, A., Hananouchi, T., Sato, N., & Nagaoka, I. (2017). Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study. Experimental and Therapeutic Medicine, 14, 4561-4571. https://doi.org/10.3892/etm.2017.5064
MLA
Sawada, Y., Sugimoto, A., Hananouchi, T., Sato, N., Nagaoka, I."Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study". Experimental and Therapeutic Medicine 14.5 (2017): 4561-4571.
Chicago
Sawada, Y., Sugimoto, A., Hananouchi, T., Sato, N., Nagaoka, I."Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4561-4571. https://doi.org/10.3892/etm.2017.5064
Copy and paste a formatted citation
x
Spandidos Publications style
Sawada Y, Sugimoto A, Hananouchi T, Sato N and Nagaoka I: Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study. Exp Ther Med 14: 4561-4571, 2017.
APA
Sawada, Y., Sugimoto, A., Hananouchi, T., Sato, N., & Nagaoka, I. (2017). Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study. Experimental and Therapeutic Medicine, 14, 4561-4571. https://doi.org/10.3892/etm.2017.5064
MLA
Sawada, Y., Sugimoto, A., Hananouchi, T., Sato, N., Nagaoka, I."Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study". Experimental and Therapeutic Medicine 14.5 (2017): 4561-4571.
Chicago
Sawada, Y., Sugimoto, A., Hananouchi, T., Sato, N., Nagaoka, I."Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double‑blind, placebo‑controlled study". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4561-4571. https://doi.org/10.3892/etm.2017.5064
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