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Article

Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease

  • Authors:
    • Xiang‑Jun Lu
    • Hai‑Tao Wang
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    Affiliations: Radiological Department, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China, Cardiothoracic Department, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China
  • Pages: 4339-4343
    |
    Published online on: August 30, 2017
       https://doi.org/10.3892/etm.2017.5068
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Abstract

The aim of the present study was to investigate the functional role of gap junction protein α 5 (Gja5) in arterial endothelial cells in the arteriogenesis that occurs during acute ischemic cardiovascular disease. Gja5 knockout mice and the femoral artery occlusion (FAO) model were used in the current study. Perfusions of both hindlimbs were obtained separately prior to FAO, immediately following FAO and 1, 3, 7, 14 and 21 days after FAO using a Laser Doppler Flow Imager. Genetic evidence concerning the gastrocnemicus (GC) muscle was collected by reverse transcription‑quantitative polymerase chain reaction. There were significant reductions in the hindlimb perfusion of Gja5‑/‑ mice compared with Gja5+/+ mice 1, 3, 7, 14 and 21 days following FAO. In Gja5+/‑ and in Gja5+/+ mice, the expression of Gja5 in the GC muscle was increased 4‑fold in the ischemic hindlimb 3 days following FAO. Levels of Gja5 expression then returned to baseline values 7 days after FAO. The results of the present study demonstrated that arterial Gja5 expression serves a functional role in acute ischemic cardiovascular disease.
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Copy and paste a formatted citation
Spandidos Publications style
Lu XJ and Wang HT: Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease. Exp Ther Med 14: 4339-4343, 2017.
APA
Lu, X., & Wang, H. (2017). Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease. Experimental and Therapeutic Medicine, 14, 4339-4343. https://doi.org/10.3892/etm.2017.5068
MLA
Lu, X., Wang, H."Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease". Experimental and Therapeutic Medicine 14.5 (2017): 4339-4343.
Chicago
Lu, X., Wang, H."Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4339-4343. https://doi.org/10.3892/etm.2017.5068
Copy and paste a formatted citation
x
Spandidos Publications style
Lu XJ and Wang HT: Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease. Exp Ther Med 14: 4339-4343, 2017.
APA
Lu, X., & Wang, H. (2017). Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease. Experimental and Therapeutic Medicine, 14, 4339-4343. https://doi.org/10.3892/etm.2017.5068
MLA
Lu, X., Wang, H."Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease". Experimental and Therapeutic Medicine 14.5 (2017): 4339-4343.
Chicago
Lu, X., Wang, H."Reduced Gja5 expression in arterial endothelial cells impairs arteriogenesis during acute ischemic cardiovascular disease". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4339-4343. https://doi.org/10.3892/etm.2017.5068
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