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Article

Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding

  • Authors:
    • Deng‑Feng Ding
    • Li‑Fang Wu
    • Ping Wang
    • Yuan‑Xu Jiang
    • Yao‑Wen Luo
    • Zhong‑Liang Dai
    • Xue‑Ping Zhang
    • Ya‑Li Li
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Shenzhen People's Hospital, Jinan University, Shenzhen, Guangdong 518020, P.R. China, Department of Anesthesiology, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010000, P.R. China
  • Pages: 4521-4526
    |
    Published online on: August 30, 2017
       https://doi.org/10.3892/etm.2017.5075
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Abstract

The aim of the present study was to investigate the effects of target‑controlled infusion (TCI) of propofol and remifentanil combined with dexmedetomidine on functional endoscopic sinus surgery (FESS) bleeding and surgical field. 62 patients scheduled to undergo FESS were randomly divided into experimental group (intravenous 0.5 µg kg‑1 h‑1 dexmedetomidine after 0.5 µg kg‑1 bolus within 15 min until the end of surgery) or control group (intravenous saline administration at the same dose). All patients underwent endotracheal intubation under general anesthesia with TCI of propofol and remifentanil for anesthesia induction and maintenance. During anesthesia, arterial pressure (MAP), heart rate (HR), intraoperative propofol and remifentanil dosage and intraoperative blood loss were recorded. Surgeons rated their satisfaction with the surgical field using the Numeric Rating Scale (NRS). Following surgery, visual analog scale (VAS) was assessed. During tracheal intubation and extubation, HR and MAP in the experimental group were significantly lower compared with the control group (P<0.05); HR was also significantly lower compared with the control group throughout surgery (P<0.05). The mean infusion rate of propofol and remifentanil was significantly lower in the experimental group compared with the control group (P=0.001 and P=0.045, respectively). Blood loss in the experimental group was significantly lower compared with the control group (P=0.007). NRS and VAS scores in the experimental group were significantly improved compared with control group (P<0.01). In conclusion, TCI of propofol and remifentanil for FESS combined with dexmedetomidine reduced intraoperative bleeding and improved the quality of surgical field compared with the same procedure without dexmedetomidine. Dexmedetomidine also reduced the increase in MAP and HR during tracheal intubation and extubation, and improved postoperative analgesia quality.
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1 

Slack R and Bates G: Functional endoscopic sinus surgery. Am Fam Physician. 58:707–718. 1998.PubMed/NCBI

2 

Cinčikas D, Ivaškevičius J, Martinkėnas JL and Balseris S: A role of anesthesiologist in reducing surgical bleeding in endoscopic sinus surgery. Medicina (Kaunas). 46:730–734. 2010.PubMed/NCBI

3 

Degoute CS: Controlled hypotension: A guide to drug choice. Drugs. 67:1053–1076. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Ge YL, Lv R, Zhou W, Ma XX, Zhong TD and Duan ML: Brain damage following severe acute normovolemic hemodilution in combination with controlled hypotension in rats. Acta Anaesthesiol Scand. 51:1331–1337. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Amorocho MR and Sordillo A: Anesthesia for functional endoscopic sinus surgery: A review. Anesthesiol Clin. 28:497–504. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Tirelli G, Bigarini S, Russolo M, Lucangelo U and Gullo A: Total intravenous anaesthesia in endoscopic sinus-nasal surgery. Acta Otorhinolaryngol Ital. 24:137–144. 2004.PubMed/NCBI

7 

Miłoński J, Zielińska-Bliźniewska H, Golusiński W, Urbaniak J, Sobański R and Olszewski J: Effects of three different types of anaesthesia on perioperative bleeding control in functional endoscopic sinus surgery. Eur Arch Otorhinolaryngol. 270:2045–2050. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Marzban S, Haddadi S, Nia Mahmoudi H, Heidarzadeh A, Nemati S and Nabi Naderi B: Comparison of surgical conditions during propofol or isoflurane anesthesia for endoscopic sinus surgery. Anesth Pain Med. 3:234–238. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Gerlach AT and Dasta JF: Dexmedetomidine: An updated review. Ann Pharmacother. 41:245–252. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Kim H, Ha SH, Kim CH, Lee SH and Choi SH: Efficacy of intraoperative dexmedetomidine infusion on visualization of the surgical field in endoscopic sinus surgery. Korean J Anesthesiol. 68:449–454. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Lee J, Kim Y, Park C, Jeon Y, Kim D, Joo J and Kang H: Comparison between dexmedetomidine and remifentanil for controlled hypotension and recovery in endoscopic sinus surgery. Ann Otol Rhinol Laryngol. 122:421–426. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Yeganeh N, Roshani B, Latifi H and Almasi A: Comparison of target-controlled infusion of sufentanil and remifentanil in blunting hemodynamic response to tracheal intubation. J Inj Violence Res. 5:101–107. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Hall DL, Weaver J, Ganzberg S, Rashid R and Wilson S: Bispectral EEG index monitoring of high-dose nitrous oxide and low-dose sevoflurane sedation. Anesth Prog. 49:56–62. 2002.PubMed/NCBI

14 

Boezaart AP, van der Merwe J and Coetzee A: Comparison of sodium nitroprusside- and esmolol-induced controlled hypotension for functional endoscopic sinus surgery. Can J Anaesth. 42:373–376. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Crawley BK, Barkdull GC, Dent S, Bishop M and Davidson TM: Relative hypotension and image guidance: Tools for training in sinus surgery. Arch Otolaryngol Head Neck Surg. 135:994–999. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Cardesín A, Pontes C, Rosell R, Escamilla Y, Marco J, Escobar MJ and Bernal-Sprekelsen M: Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: An observational study. Eur Arch Otorhinolaryngol. 271:1505–1511. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Jacobi KE, Böhm BE, Rickauer AJ, Jacobi C and Hemmerling TM: Moderate controlled hypotension with sodium nitroprusside does not improve surgical conditions or decrease blood loss in endoscopic sinus surgery. J Clin Anesth. 12:202–207. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Srivastava U, Dupargude AB, Kumar D, Joshi K and Gupta A: Controlled hypotension for functional endoscopic sinus surgery: Comparison of esmolol and nitroglycerine. Indian J Otolaryngol Head Neck Surg. 65:440–444. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Wormald PJ, Athanasiadis T, Rees G and Robinson S: An evaluation of effect of pterygopalatine fossa injection with local anesthetic and adrenalin in the control of nasal bleeding during endoscopic sinus surgery. Am J Rhinol. 19:288–292. 2005.PubMed/NCBI

20 

Nair S, Collins M, Hung P, Rees G, Close D and Wormald PJ: The effect of beta-blocker premedication on the surgical field during endoscopic sinus surgery. Laryngoscope. 114:1042–1046. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Eberhart LH, Folz BJ, Wulf H and Geldner G: Intravenous anesthesia provides optimal surgical conditions during microscopic and endoscopic sinus surgery. Laryngoscope. 113:1369–1373. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Wormald PJ, van Renen G, Perks J, Jones JA and Langton-Hewer CD: The effect of the total intravenous anesthesia compared with inhalational anesthesia on the surgical field during endoscopic sinus surgery. Am J Rhinol. 19:514–520. 2005.PubMed/NCBI

23 

Toivonen J, Virtanen H and Kaukinen S: Deliberate hypotension induced by labetalol with halothane, enflurane or isoflurane for middle-ear surgery. Acta Anaesthesiol Scand. 33:283–289. 1989. View Article : Google Scholar : PubMed/NCBI

24 

Snidvongs K, Tingthanathikul W, Aeumjaturapat S and Chusakul S: Dexmedetomidine improves the quality of the operative field for functional endoscopic sinus surgery: Systematic review. J Laryngol Otol. 129:S8–13. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Ragab SM and Hassanin MZ: Optimizing the surgical field in pediatric functional endoscopic sinus surgery: A new evidence-based approach. Otolaryngol Head Neck Surg. 142:48–54. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Shams T, El Bahnasawe NS, Abu-Samra M and El-Masry R: Induced hypotension for functional endoscopic sinus surgery: A comparative study of dexmedetomidine versus esmolol. Saudi J Anaesth. 7:175–180. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Talke P, Lobo E and Brown R: Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans. Anesthesiology. 99:65–70. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Larsen R and Kleinschmidt S: Controlled hypotension. Anaesthesist. 44:291–308. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Sieśkiewicz A, Drozdowski A and Rogowski M: The assessment of correlation between mean arterial pressure and intraoperative bleeding during endoscopic sinus surgery in patients with low heart rate. Otolaryngol Pol. 64:225–228. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Monk TG, Saini V, Weldon BC and Sigl JC: Anesthetic management and one-year mortality after noncardiac surgery. Anesth Analg. 100:4–10. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Arcangeli A, D'Alò C and Gaspari R: Dexmedetomidine use in general anaesthesia. Curr Drug Targets. 10:687–695. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Gunalan S, Venkatraman R, Sivarajan G and Sunder P: Comparative evaluation of bolus administration of dexmedetomidine and fentanyl for stress attenuation during laryngoscopy and endotracheal intubation. J Clin Diagn Res. 9:UC06–UC09. 2015.PubMed/NCBI

33 

Fan Q, Hu C, Ye M and Shen X: Dexmedetomidine for tracheal extubation in deeply anesthetized adult patients after otologic surgery: A comparison with remifentanil. BMC Anesthesiol. 15:1062015. View Article : Google Scholar : PubMed/NCBI

34 

Guven DG, Demiraran Y, Sezen G, Kepek O and Iskender A: Evaluation of outcomes in patients given dexmedetomidine in functional endoscopic sinus surgery. Ann Otol Rhinol Laryngol. 120:586–592. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding DF, Wu LF, Wang P, Jiang YX, Luo YW, Dai ZL, Zhang XP and Li YL: Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding. Exp Ther Med 14: 4521-4526, 2017.
APA
Ding, D., Wu, L., Wang, P., Jiang, Y., Luo, Y., Dai, Z. ... Li, Y. (2017). Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding. Experimental and Therapeutic Medicine, 14, 4521-4526. https://doi.org/10.3892/etm.2017.5075
MLA
Ding, D., Wu, L., Wang, P., Jiang, Y., Luo, Y., Dai, Z., Zhang, X., Li, Y."Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding". Experimental and Therapeutic Medicine 14.5 (2017): 4521-4526.
Chicago
Ding, D., Wu, L., Wang, P., Jiang, Y., Luo, Y., Dai, Z., Zhang, X., Li, Y."Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4521-4526. https://doi.org/10.3892/etm.2017.5075
Copy and paste a formatted citation
x
Spandidos Publications style
Ding DF, Wu LF, Wang P, Jiang YX, Luo YW, Dai ZL, Zhang XP and Li YL: Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding. Exp Ther Med 14: 4521-4526, 2017.
APA
Ding, D., Wu, L., Wang, P., Jiang, Y., Luo, Y., Dai, Z. ... Li, Y. (2017). Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding. Experimental and Therapeutic Medicine, 14, 4521-4526. https://doi.org/10.3892/etm.2017.5075
MLA
Ding, D., Wu, L., Wang, P., Jiang, Y., Luo, Y., Dai, Z., Zhang, X., Li, Y."Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding". Experimental and Therapeutic Medicine 14.5 (2017): 4521-4526.
Chicago
Ding, D., Wu, L., Wang, P., Jiang, Y., Luo, Y., Dai, Z., Zhang, X., Li, Y."Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4521-4526. https://doi.org/10.3892/etm.2017.5075
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