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Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease

  • Authors:
    • Furong Guo
    • Xin Yi
    • Mingjiang Li
    • Jinrong Fu
    • Sha Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4231-4237
    |
    Published online on: August 31, 2017
       https://doi.org/10.3892/etm.2017.5084
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Abstract

The present study investigated the association between Snail1 and atrial fibrosis in patients with atrial fibrillation (AF) and rheumatic heart disease (RHD) and to determine the possible mechanism underlying this interrelation. A total of 19 patients were included in the current study and were divided into two groups: A sinus rhythm (SR) group (n=9) and an AF group (n=10). All patients underwent heart valve replacement surgery, during which ~200 mg right atrium tissue was obtained. Hematoxylin and eosin and Masson's trichrome‑stained sections were used to evaluate the morphological changes of cardiomyocytes and the level of fibrosis. Immunohistochemistry was applied to observe the location and expression of Snail1. Reverse transcription‑quantitative polymerase chain reaction was used to measure Snail1 mRNA levels. Western blotting was used to determine changes in the expression of Snail1, as well as in the expression of proteins involved in the Wnt pathway, including Wnt1, Wnt 3a, Wnt8a, Wnt5a and Wnt11. Compared with the SR group, expanded cardiomyocytes and higher collagen deposition was detected in the atrial tissue of the AF group. The expression of Snail1 mRNA and protein was significantly higher in the AF group than in the SR group (P<0.05). Additionally, the expression of Wnt1, 3a and 8a in the canonical Wnt signaling pathway, and Wnt5a and 11 in the noncanonical Wnt signaling pathway were significantly increased in the AF group. Furthermore, the phosphorylation level of glycogen synthase kinase 3β (GSK3β) and the levels of β‑catenin and GSK3β were significantly increased in the AF group compared with the SR group (P<0.05). Snail1 may be involved in the development and maintenance of atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease and may be developed as a novel biomarker to evaluate myocardial fibrosis in the future. Additionally, the current study suggests that the Wnt signaling pathway may participate in the process of increased Snail1 expression and atrial fibrosis in patients with AF and RHD.
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1 

Li M, Yi X, Ma L and Zhou Y: Hepatocyte growth factor and basic fibroblast growth factor regulate atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease via the mitogen-activated protein kinase signaling pathway. Exp Ther Med. 6:1121–1126. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Jalife J and Kaur K: Atrial remodeling, fibrosis, and atrial fibrillation. Trends Cardiovasc Med. 25:475–484. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Tan AY and Zimetbaum P: Atrial fibrillation and atrial fibrosis. J Cardiovasc Pharmacol. 57:625–629. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Sun Y, Huang ZY, Wang ZH, Li CP, Meng XL, Zhang YJ, Su F and Ma N: TGF-β1 and TIMP-4 regulate atrial fibrosis in atrial fibrillation secondary to rheumatic heart disease. Mol Cell Biochem. 406:131–138. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Zhang YJ, Ma N, Su F, Liu H and Mei J: Increased TRPM6 expression in atrial fibrillation patients contribute to atrial fibrosis. Exp Mol Pathol. 98:486–490. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Miyasato SK, Loeffler J, Shohet R, Zhang J, Lindsey M and Le Saux CJ: Caveolin-1 modulates TGF-β1 signaling in cardiac remodeling. Matrix Biol. 30:318–329. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Zhang L, Huang B, Scherlag BJ, Ritchey JW, Embi AA, Hu J, Hou Y and Po SS: Structural changes in the progression of atrial fibrillation: Potential role of glycogen and fibrosis as perpetuating factors. Int J Clin Exp Pathol. 8:1712–1718. 2015.PubMed/NCBI

8 

Kiryu M, Niwano S, Niwano H, Kishihara J, Aoyama Y, Fukaya H, Masaki Y and Izumi T: Angiotensin II-mediated up-regulation of connective tissue growth factor promotes atrial tissue fibrosis in the canine atrial fibrillation model. Europace. 14:1206–1214. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wang R, Yi X, Li X and Jiang X: Fibroblast growth factor-21 is positively associated with atrial fibrosis in atrial fibrillation patients with rheumatic heart disease. Int J Clin Exp Pathol. 8:14901–14908. 2015.PubMed/NCBI

10 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Baum B, Settleman J and Quinlan MP: Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol. 19:294–308. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K and Hasegawa Y: Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 43:161–172. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Tennakoon AH, Izawa T, Kuwamura M and Yamate J: Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in renal and hepatic fibrosis. J Clin Med. 5:pii:E42015. View Article : Google Scholar

14 

Widyantoro B, Emoto N, Nakayama K, Anggrahini DW, Adiarto S, Iwasa N, Yagi K, Miyagawa K, Rikitake Y, Suzuki T, et al: Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation. 121:2407–2418. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Barrallo-Gimeno A and Nieto MA: The Snail genes as inducers of cell movement and survival: Implications in development and cancer. Development. 132:3151–3161. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Liu Y, Du J, Zhang J, Weng M, Li X, Pu D, Gao L, Deng S, Xia S and She Q: Snail1 is involved in de novo cardiac fibrosis after myocardial infarction in mice. Acta Biochim Biophys Sin (Shanghai). 44:902–910. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Dang Y, Liu B, Xu P, Zhu P, Zhai Y, Liu M and Ye X: Gpr48 deficiency induces polycystic kidney lesions and renal fibrosis in mice by activating Wnt signal pathway. PLoS One. 9:e898352014. View Article : Google Scholar : PubMed/NCBI

18 

Kim TH, Kim SH, Seo JY, Chung H, Kwak HJ, Lee SK, Yoon HJ, Shin DH, Park SS and Sohn JW: Blockade of the Wnt/β-catenin pathway attenuates bleomycin-induced pulmonary fibrosis. Tohoku J Exp Med. 223:45–54. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Ge WS, Wang YJ, Wu JX, Fan JG, Chen YW and Zhu L: β-catenin is overexpressed in hepatic fibrosis and blockage of Wnt/β-catenin signaling inhibits hepatic stellate cell activation. Mol Med Rep. 9:2145–2151. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Yu F, Lu Z, Huang K, Wang X, Xu Z, Chen B, Dong P and Zheng J: MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis. Oncotarget. 7:81–93. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Boutet A, De Frutos CA, Maxwell PH, Mayol MJ, Romero J and Nieto MA: Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J. 25:5603–5613. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Xu-Dubois YC, Galichon P, Brocheriou I, Baugey E, Morichon R, Jouanneau C, Ouali N, Rondeau E and Hertig A: Expression of the transcriptional regulator snail1 in kidney transplants displaying epithelial-to-mesenchymal transition features. Nephrol Dial Transplant. 29:2136–2144. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Rowe RG, Lin Y, Shimizu-Hirota R, Hanada S, Neilson EG, Greenson JK and Weiss SJ: Hepatocyte-derived Snail1 propagates liver fibrosis progression. Mol Cell Biol. 31:2392–2403. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, et al: Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 121:1894–1904. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan JN, Rojas M, Willis M, Leask A, et al: Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 31:429–442. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Ohnuki K, Umezono T, Abe M, Kobayashi T, Kato M, Miyauchi M, Yamamoto N, Kimura M, Toyoda M and Suzuki D: Expression of transcription factor Snai1 and tubulointerstitial fibrosis in progressive nephropathy. J Nephrol. 25:233–239. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo F, Yi X, Li M, Fu J and Li S: Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease. Exp Ther Med 14: 4231-4237, 2017.
APA
Guo, F., Yi, X., Li, M., Fu, J., & Li, S. (2017). Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease. Experimental and Therapeutic Medicine, 14, 4231-4237. https://doi.org/10.3892/etm.2017.5084
MLA
Guo, F., Yi, X., Li, M., Fu, J., Li, S."Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease". Experimental and Therapeutic Medicine 14.5 (2017): 4231-4237.
Chicago
Guo, F., Yi, X., Li, M., Fu, J., Li, S."Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4231-4237. https://doi.org/10.3892/etm.2017.5084
Copy and paste a formatted citation
x
Spandidos Publications style
Guo F, Yi X, Li M, Fu J and Li S: Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease. Exp Ther Med 14: 4231-4237, 2017.
APA
Guo, F., Yi, X., Li, M., Fu, J., & Li, S. (2017). Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease. Experimental and Therapeutic Medicine, 14, 4231-4237. https://doi.org/10.3892/etm.2017.5084
MLA
Guo, F., Yi, X., Li, M., Fu, J., Li, S."Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease". Experimental and Therapeutic Medicine 14.5 (2017): 4231-4237.
Chicago
Guo, F., Yi, X., Li, M., Fu, J., Li, S."Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4231-4237. https://doi.org/10.3892/etm.2017.5084
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