Open Access

MicroRNA‑155 regulates the proliferation, cell cycle, apoptosis and migration of colon cancer cells and targets CBL

  • Authors:
    • Hua Yu
    • Weiling Xu
    • Fangchao Gong
    • Baorong Chi
    • Junyi Chen
    • Ling Zhou
  • View Affiliations

  • Published online on: August 31, 2017     https://doi.org/10.3892/etm.2017.5085
  • Pages: 4053-4060
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNA‑155 (miR‑155) is a well‑studied miR and acts as an oncomiR in numerous cancer types. However, the biological functions of miR‑155 in colon cancer as well as its target genes have remained to be fully elucidated. In order to investigate the biological functions of miR‑155, MTT, colony formation and wound healing assays, cell cycle analysis and detection of apoptosis were performed. The results demonstrated that miR‑155 promoted the proliferation of colon cancer cells and enhanced their colony formation capacity, promoted their cell cycle progression and inhibited apoptosis. miR‑155 also promoted the migration of colon cancer cells. In the present study, casitas B‑lineage lymphoma was identified as a novel target of miR‑155. The present study suggested that miR‑155 functions as an oncomiR in colon cancer cells and may become a promising therapeutic target for colon cancer therapy.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yu H, Xu W, Gong F, Chi B, Chen J and Zhou L: MicroRNA‑155 regulates the proliferation, cell cycle, apoptosis and migration of colon cancer cells and targets CBL. Exp Ther Med 14: 4053-4060, 2017
APA
Yu, H., Xu, W., Gong, F., Chi, B., Chen, J., & Zhou, L. (2017). MicroRNA‑155 regulates the proliferation, cell cycle, apoptosis and migration of colon cancer cells and targets CBL. Experimental and Therapeutic Medicine, 14, 4053-4060. https://doi.org/10.3892/etm.2017.5085
MLA
Yu, H., Xu, W., Gong, F., Chi, B., Chen, J., Zhou, L."MicroRNA‑155 regulates the proliferation, cell cycle, apoptosis and migration of colon cancer cells and targets CBL". Experimental and Therapeutic Medicine 14.5 (2017): 4053-4060.
Chicago
Yu, H., Xu, W., Gong, F., Chi, B., Chen, J., Zhou, L."MicroRNA‑155 regulates the proliferation, cell cycle, apoptosis and migration of colon cancer cells and targets CBL". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4053-4060. https://doi.org/10.3892/etm.2017.5085