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Article

Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice

  • Authors:
    • Jinbo Zhang
    • Shiqing Li
    • Li Sun
    • Yanxia Chen
    • Lei Zhang
    • Zhenghui Zhang
  • View Affiliations / Copyright

    Affiliations: Center for Preventive Treatment of Disease, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264016, P.R. China, Department of Encephalopathy, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264016, P.R. China, Department of Gynecology and Obstetrics, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264016, P.R. China, Department of Rehabilitation, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264016, P.R. China, Department of Heart Disease, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264016, P.R. China
  • Pages: 4453-4459
    |
    Published online on: September 1, 2017
       https://doi.org/10.3892/etm.2017.5092
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Abstract

Particulate matter 2.5 (PM2.5) is a growing concern worldwide due to its association with respiratory diseases, including chronic obstructive pulmonary disease (COPD). Stemonine, a traditional Chinese herb, has been demonstrated to exhibit anti‑inflammatory and antioxidant properties, making it a potential drug for the treatment of respiratory diseases. The therapeutic effects of stemonine on mice with PM2.5‑induced COPD were investigated in the present study. Kunming mice were randomly divided into the following five groups (n=10/group): Control, model, low‑dose stemonine, moderate‑dose stemonine and high‑dose stemonine. The model mice received an intranasal instillation of PM2.5 suspension (40 mg/kg). The levels of specific enzymes, markers of oxidative stress, and the inflammatory cytokines tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 were measured in the bronchoalveolar lavage fluid of the mice using ELISA kits. Hematoxylin and eosin staining was performed to determine inflammatory changes to the lung tissue. It was demonstrated that stemonine could significantly alleviate lung injury by decreasing the levels of enzymes and cytokines associated with inflammation and oxidative stress in a dose‑dependent manner. In addition, stemonine dose‑dependently increased the amount of superoxide dismutase. These results suggest that stemonine reduces lung inflammation in mice with PM2.5‑induced COPD, providing a novel approach for the treatment of PM2.5‑induced respiratory diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Li S, Sun L, Chen Y, Zhang L and Zhang Z: Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice. Exp Ther Med 14: 4453-4459, 2017.
APA
Zhang, J., Li, S., Sun, L., Chen, Y., Zhang, L., & Zhang, Z. (2017). Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice. Experimental and Therapeutic Medicine, 14, 4453-4459. https://doi.org/10.3892/etm.2017.5092
MLA
Zhang, J., Li, S., Sun, L., Chen, Y., Zhang, L., Zhang, Z."Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice". Experimental and Therapeutic Medicine 14.5 (2017): 4453-4459.
Chicago
Zhang, J., Li, S., Sun, L., Chen, Y., Zhang, L., Zhang, Z."Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4453-4459. https://doi.org/10.3892/etm.2017.5092
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Li S, Sun L, Chen Y, Zhang L and Zhang Z: Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice. Exp Ther Med 14: 4453-4459, 2017.
APA
Zhang, J., Li, S., Sun, L., Chen, Y., Zhang, L., & Zhang, Z. (2017). Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice. Experimental and Therapeutic Medicine, 14, 4453-4459. https://doi.org/10.3892/etm.2017.5092
MLA
Zhang, J., Li, S., Sun, L., Chen, Y., Zhang, L., Zhang, Z."Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice". Experimental and Therapeutic Medicine 14.5 (2017): 4453-4459.
Chicago
Zhang, J., Li, S., Sun, L., Chen, Y., Zhang, L., Zhang, Z."Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4453-4459. https://doi.org/10.3892/etm.2017.5092
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