Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma

  • Authors:
    • Huilong Chen
    • Xiangqin Xu
    • Sheng Cheng
    • Yuzhu Xu
    • Qi Xuefei
    • Yong Cao
    • Jungang Xie
    • Cong‑Yi Wang
    • Yongjian Xu
    • Weining Xiong
  • View Affiliations

  • Published online on: September 1, 2017     https://doi.org/10.3892/etm.2017.5093
  • Pages: 4391-4396
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Abstract

Asthma is a chronic T helper type 2 (Th2) cell‑mediated inflammatory disease characterized by airway hyperresponsiveness (AHR) and airway inflammation. Although the majority of patients with asthma can achieve a good level of control with existing treatments, asthma runs a chronic course and the effectiveness of current treatment is not satisfactory for certain patients. MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the post‑transcriptional level; their role in regulating allergic inflammation remains largely unknown. The present study aimed to explore the role of miRNA‑155 in the pathogenesis of asthma and its potential as a target for treatment. The expression of miRNA‑155 increased in ovalbumin‑sensitized and challenged mice compared with control mice, and lentiviral vector‑delivered small interfering (si)RNA targeting miRNA‑155 resulted in reduced AHR, airway inflammation and Th2 cytokine production. The data from the present study indicate that miRNA‑155 serves an important role in the pathogenesis of asthma, and that lentiviral vector‑delivered siRNA targeting miRNA‑155 may serve as a novel approach for the treatment of allergic asthma.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen H, Xu X, Cheng S, Xu Y, Xuefei Q, Cao Y, Xie J, Wang CY, Xu Y, Xiong W, Xiong W, et al: Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma. Exp Ther Med 14: 4391-4396, 2017
APA
Chen, H., Xu, X., Cheng, S., Xu, Y., Xuefei, Q., Cao, Y. ... Xiong, W. (2017). Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma. Experimental and Therapeutic Medicine, 14, 4391-4396. https://doi.org/10.3892/etm.2017.5093
MLA
Chen, H., Xu, X., Cheng, S., Xu, Y., Xuefei, Q., Cao, Y., Xie, J., Wang, C., Xu, Y., Xiong, W."Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma". Experimental and Therapeutic Medicine 14.5 (2017): 4391-4396.
Chicago
Chen, H., Xu, X., Cheng, S., Xu, Y., Xuefei, Q., Cao, Y., Xie, J., Wang, C., Xu, Y., Xiong, W."Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4391-4396. https://doi.org/10.3892/etm.2017.5093