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Article

Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma

  • Authors:
    • Mateusz Jonakowski
    • Jan Zioło
    • Marcelina Koćwin
    • Marcelina Przemęcka
    • Łukasz Mokros
    • Michał Panek
    • Janusz Szemraj
    • Piotr Kuna
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 90‑153 Lodz, Poland, Department of Clinical Pharmacology, Medical University of Lodz, 90‑153 Lodz, Poland, Department of Medical Biochemistry, Medical University of Lodz, 92‑215 Lodz, Poland
  • Pages: 4533-4540
    |
    Published online on: September 5, 2017
       https://doi.org/10.3892/etm.2017.5108
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Abstract

Transforming growth factor (TGF)‑β1 has an essential role in bronchitis and the induction of bronchial remodelling, which are critical processes in the pathogenesis of asthma. However, the role of interleukin (IL)‑15 in asthma inflammation remains unclear. The aim of the present study was to evaluate the effect of TGF‑β1 mRNA expression on IL‑15 mRNA expression in asthmatic patients and to assess the role of IL‑15 in the clinical course of asthma. The study included 221 participants, comprising 130 patients with asthma and 91 healthy volunteers. The participants were subjected to testing using spirometry, as well as the Asthma Control Test™ and Borg Scale. The expression of TGF‑β1 and IL‑15 mRNA was analyzed in blood samples using reverse transcription‑quantitative polymerase chain reaction. Statistical analysis indicated that IL‑15 and TGF‑β1 mRNA expression each differed significantly between the patient and control groups (P=0.0016 and P=0.033, respectively). A significant correlation was identified between IL‑15 expression and TGF‑β1 expression (R=0.41, P=0.0005). No correlation was observed between IL‑15 expression and the degree of asthma severity, the results of spirometric examination or the frequency of asthma exacerbations. Further analysis revealed that IL‑15 expression was elevated following the administration of inhaled glucocorticosteroids (iGCs; P=0.024), and reduced following methylxanthine treatment (P<0.001). The occurrence of dyspnoea differed between the study and control groups, and this was not found to be associated with IL‑15 expression. Since IL‑15 expression was correlated with TGF‑β1 expression among asthmatic patients, and IL‑15 expression was elevated following iGC administration, the results of the study suggest that IL‑15 activity might be associated with the pathogenesis of asthma.
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1 

Droszcz W: AstmaWydawnictwo Lekarskie PZWL. Warszawa: 2007

2 

Reddel HK and Levy ML: The GINA asthma strategy report: What's new for primary care? Primary Care Respiratory Med. 25:150502015. View Article : Google Scholar

3 

Bel EH: Clinical phenotypes of asthma. Curr Opin Pulm Med. 10:44–50. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Moustakas A: Smad signalling network. J Cell Sci. 115:3355–3356. 2002.PubMed/NCBI

5 

Attisano L and Wrana JL: Signal transduction by the TGF-beta superfamily. Science. 296:1646–1647. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Verrecchia F and Mauviel A: Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation. J Invest Dermatol. 118:211–215. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Halwani R, Al-Muhsen S, Al-Jahdali H and Hamid Q: Role of transforming growth factor-β in airway remodeling in asthma. Am J Respir Cell Mol Biol. 44:127–133. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Letterio JJ and Roberts AB: TGF-beta: A critical modulator of immune cell function. Clin Immunol Immunopathol. 84:244–250. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Duvernelle C, Freund V and Frossard N: Transforming growth factor-beta and its role in asthma. Pulm Pharmacol Ther. 16:181–196. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Mehta AA and Mahajan S: Role of cytokines in pathophysiology of asthma. Iranian J Pharmacol Therapeut. 5:1–14. 2006.

11 

McInnes IB and Gracie JA: Interleukin-15: A new cytokine target for the treatment of inflammatory diseases. Curr Opin Pharmacol. 4:392–397. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Anderson DM, Johnson L, Glaccum MB, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW, et al: Chromosomal assignment and genomic structure of II15. Genomics. 25:701–706. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Doherty TM, Seder RA and Sher A: Induction and regulation of IL-15 expression in murine macrophages. J Immunol. 156:735–741. 1996.PubMed/NCBI

14 

Kennedy MK and Park LS: Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex. J Clin Immunol. 16:134–143. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Leclercq G, Debacker V, de Smedt M and Plum J: Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells. J Exp Med. 184:325–336. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Armitage RJ, Macduff BM, Eisenman J, Paxton R and Grabstein KH: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol. 154:483–490. 1995.PubMed/NCBI

17 

Kirman I, Vainer B and Nielsen OH: Interleukin-15 and its role in chronic inflammatory diseases. Inflamm Res. 47:285–289. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Muro S, Taha R, Tsicopoulos A, Olivenstein R, Tonnel AB, Christodoulopoulos P, Wallaert B and Hamid Q: Expression of IL-15 in inflammatory pulmonary diseases. J Allergy Clin Immunol. 108:970–975. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Hoontrakoon R, Chu HW, Gardai SJ, Wenzel SE, McDonald P, Fadok VA, Henson PM and Bratton DL: Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation. Am J Respir Cell Mol Biol. 26:404–412. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Mori A, Suko M, Kaminuma O, Inoue S, Ohmura T, Nishizaki Y, Nagahori T, Asakura Y, Hoshino A, Okumura Y, et al: IL-15 promotes cytokine production of human T helper cells. J Immunol. 156:2400–2405. 1996.PubMed/NCBI

21 

Ishimitsu R, Nishimura H, Yajima T, Watase T, Kawauchi H and Yoshikai Y: Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma. J Immunol. 166:1991–2001. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Laza-Stanca V, Message SD, Edwards MR, Parker HL, Zdrenghea MT, Kebadze T, Kon OM, Mallia P, Stanciu LA and Johnston SL: The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. PLoS Pathog. 7:e10021142011. View Article : Google Scholar : PubMed/NCBI

23 

Komai-Koma M, McKay A, Thomson L, McSharry C, Chalmers GW, Liew FY and Thomson NC: Immuno-regulatory cytokines in asthma: IL-15 and IL-13 in induced sputum. Clin Exp Allergy. 31:1441–1448. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention, Updated. 2017.http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention/

25 

Zalecenia Polskiego Towarzystwa Ftyzjopneumonologicznego dotyczące wykonywania badań spirometrycznych. PPneumonologia i Alergologia Polska. 74 (Suppl 1):2006.

26 

Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, et al: Standardisation of spirometry. Eur Respir J. 26:319–338. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ and Pendergraft TB: Development of the asthma control test: A survey for assessing asthma control. J Allergy Clin Immunol. 113:59–65. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Borg GA: Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 14:377–381. 1982. View Article : Google Scholar : PubMed/NCBI

29 

Chomczynski P and Sacchi N: The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on. Nat Protoc. 1:581–585. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987. View Article : Google Scholar : PubMed/NCBI

31 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Winer J, Jung CK, Shackel I and Williams PM: Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem. 270:41–49. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Panek M, Pietras T, Szemraj J, Fabijan A and Kuna P: Identification and association of TGFβ-1 expression in patients with asthma in a Polish population-Lodz metropolitan area study. Int J Biochem Mol Biol. 4:67–74. 2013.PubMed/NCBI

34 

Koćwin M, Jonakowski M, Przemęcka M, Zioło J, Panek M and Kuna P: The role of the TGF-SMAD signalling pathway in the etiopathogenesis of severe asthma. Pneumonol Alergol Pol. 84:290–301. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Panek M, Pietras T, Fabijan A, Zioło J, Wieteska L, Małachowska B, Fendler W, Szemraj J and Kuna P: Identification and association of the single nucleotide polymorphisms, C-509T, C+466T and T+869C, of the TGF-β1 gene in patients with asthma and their influence on the mRNA expression level of TGF-β1. Int J Mol Med. 34:975–986. 2014.PubMed/NCBI

36 

Panek M, Pietras T, Fabijan A, Zioło J, Wieteska Ł, Małachowska B, Fendler W, Szemraj J and Kuna P: The NR3C1 glucocorticoid receptor gene polymorphisms may modulate the TGF-beta mRNA expression in asthma patients. Inflammation. 38:1479–1492. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Christensen U, Haagerup A, Binderup HG, Vestbo J, Kruse TA and Børglum AD: Family based association analysis of the IL2 and IL15 genes in allergic disorders. Eur J Hum Genet. 14:227–235. 2005. View Article : Google Scholar

38 

Pinto LA, Depner M, Steudemann L, Klopp N, Illig T, von Mutius E and Kabesch M: IL15 gene variants are not associated with asthma and atopy. Allergy. 64:643–646. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Bierbaum S, Nickel R, Zitnik S, Ahlert I, Lau S, Deichmann KA, Wahn U and Heinzmann A: Confirmation of association of IL-15 with pediatric asthma and comparison of different controls. Allergy. 61:576–580. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Jachnik M, Szczepankiewicz A and Bręborowicz A: Influence of IL15 gene polymorphism on the course of bronchial asthma in children. Alergia Astma Immunologia. 16:200–204. 2011.

41 

Sanjabi S, Mosaheb MM and Flavell RA: Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity. 31:131–144. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Benahmed M, Meresse B, Arnulf B, Barbe U, Mention JJ, Verkarre V, Allez M, Cellier C, Hermine O and Cerf-Bensussan N: Inhibition of TGF-beta signaling by IL-15: A new role for IL-15 in the loss of immune homeostasis in celiac disease. Gastroenterology. 132:994–1008. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Zdrenghea MT, Telcian AG, Laza-Stanca V, Bellettato CM, Edwards MR, Nikonova A, Khaitov MR, Azimi N, Groh V, Mallia P, et al: RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells. Eur Respir J. 39:712–720. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Azimi N, Shiramizu KM, Tagaya Y, Mariner J and Waldmann TA: Viral activation of interleukin-15 (IL-15): Characterization of a virus-inducible element in the IL-15 promoter region. J Virol. 74:7338–7348. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Esen M, Forster J, Ajua A, Spänkuch I, Paparoupa M, Mordmüller B and Kremsner PG: Effect of IL-15 on IgG versus IgE antibody-secreting cells in vitro. J Immunol Methods. 375:7–13. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Roth M, Zhao F, Zhong J, Lardinois D and Tamm M: Serum IgE induced airway smooth muscle cell remodeling is independent of allergens and is prevented by omalizumab. PLoS One. 10:e01365492015. View Article : Google Scholar : PubMed/NCBI

47 

Domingo C: Omalizumab for severe asthma: Efficacy beyond the atopic patient? Drugs. 74:521–533. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Menzella F, Piro R, Facciolongo N, Castagnetti C, Simonazzi A and Zucchi L: Long-term benefits of omalizumab in a patient with severe non-allergic asthma. Allergy Asthma Clin Immunol. 7:92011. View Article : Google Scholar : PubMed/NCBI

49 

Kupryś-Lipińska I and Kuna P: Omalizumab, recombinant humanized monoclonal antibody anti-IgE-new fields of studies on the therapeutic indications. Pneumonol Alergol Pol. 77:43–51. 2009.(In Polish). PubMed/NCBI

50 

Yan L, Xiao-Ling S, Zheng-Yan C, Guo-Ping L, Sen Z and Zhuang C: HSP70/CD80 DNA vaccine inhibits airway remodeling by regulating the transcription factors T-bet and GATA-3 in a murine model of chronic asthma. Archives Med Sci. 9:906–915. 2013. View Article : Google Scholar

51 

Moustaki A, Argyropoulos KV, Baxevanis CN, Papamichail M and Perez SA: Effect of the simultaneous administration of glucocorticoids and IL-15 on human NK cell phenotype, proliferation and function. Cancer Immunol Immunother. 60:1683–1695. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Wiegers GJ and Reul JM: Induction of cytokine receptors by glucocorticoids: Functional and pathological significance. Trends Pharmacol Sci. 19:317–321. 1998. View Article : Google Scholar : PubMed/NCBI

53 

Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, et al: Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol. 13:1187–1195. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Sher ER, Leung DY, Surs W, Kam JC, Zieg G, Kamada AK and Szefler SJ: Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest. 93:33–39. 1994. View Article : Google Scholar : PubMed/NCBI

55 

Sugiura H, Kawabata H, Ichikawa T, Koarai A, Yanagisawa S, Kikuchi T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, et al: Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 302:L764–L774. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Layseca-Espinosa E, Sanchez-Madrid F and Gonzalez-Amaro R: Phosphodiesterase inhibitors as immunomodulatory drugs. Inmunología. 22:39–52. 2003.

57 

Cohen Y, Eini H, Chaimovitz C and Douvdevani A: 53: Inhibition of interleukin-15 dependent cytotoxic T-cell proliferation by the action of adenosine on dendritic cell. Cytokine. 63:255–256. 2013. View Article : Google Scholar

58 

Zdrenghea MT: Could interleukin-15 potentiate histone deacetylase inhibitor effects in haematological malignancy? Med Hypotheses. 81:311–315. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jonakowski M, Zioło J, Koćwin M, Przemęcka M, Mokros Ł, Panek M, Szemraj J and Kuna P: Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma. Exp Ther Med 14: 4533-4540, 2017.
APA
Jonakowski, M., Zioło, J., Koćwin, M., Przemęcka, M., Mokros, Ł., Panek, M. ... Kuna, P. (2017). Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma. Experimental and Therapeutic Medicine, 14, 4533-4540. https://doi.org/10.3892/etm.2017.5108
MLA
Jonakowski, M., Zioło, J., Koćwin, M., Przemęcka, M., Mokros, Ł., Panek, M., Szemraj, J., Kuna, P."Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma". Experimental and Therapeutic Medicine 14.5 (2017): 4533-4540.
Chicago
Jonakowski, M., Zioło, J., Koćwin, M., Przemęcka, M., Mokros, Ł., Panek, M., Szemraj, J., Kuna, P."Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4533-4540. https://doi.org/10.3892/etm.2017.5108
Copy and paste a formatted citation
x
Spandidos Publications style
Jonakowski M, Zioło J, Koćwin M, Przemęcka M, Mokros Ł, Panek M, Szemraj J and Kuna P: Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma. Exp Ther Med 14: 4533-4540, 2017.
APA
Jonakowski, M., Zioło, J., Koćwin, M., Przemęcka, M., Mokros, Ł., Panek, M. ... Kuna, P. (2017). Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma. Experimental and Therapeutic Medicine, 14, 4533-4540. https://doi.org/10.3892/etm.2017.5108
MLA
Jonakowski, M., Zioło, J., Koćwin, M., Przemęcka, M., Mokros, Ł., Panek, M., Szemraj, J., Kuna, P."Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma". Experimental and Therapeutic Medicine 14.5 (2017): 4533-4540.
Chicago
Jonakowski, M., Zioło, J., Koćwin, M., Przemęcka, M., Mokros, Ł., Panek, M., Szemraj, J., Kuna, P."Role of IL‑15 in the modulation of TGF‑β1‑mediated inflammation in asthma". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4533-4540. https://doi.org/10.3892/etm.2017.5108
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