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Article Open Access

Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate

  • Authors:
    • Lili Qin
    • Wenjun Qin
    • Jianfei Wang
    • Lin Lin
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Urology, Hanting People's Hospital of Weifang, Weifang, Shandong 261100, P.R. China, Department of Radiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
    Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5012-5016
    |
    Published online on: September 12, 2017
       https://doi.org/10.3892/etm.2017.5115
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Abstract

This study investigated the effects of alprostadil combined with calcium dobesilate on the treatment of diabetic nephropathy. We recruited 80 patients with diabetic nephropathy, who were randomly divided into experimental (n=40) and control (n=40) groups. Patients received high-quality low-protein diabetic diet intervention and subcutaneous injection of insulin to adjust blood glucose, combined with antihypertensive, antiplatelet drugs, and other comprehensive treatments. The control group received alprostadil and the experimental group received alprostadil combined with calcium dobesilate. Both groups were treated for 12 weeks as one treatment cycle. The time to remission of clinical symptoms such as mental fatigue and weakness, limb edema, soreness and swelling of waist and knee, cold limbs and limb numbness and pain was significantly shorter in the experimental group than that in the control group (p<0.05). After intervention, the blood levels of small molecular weight proteins, such as β2-microglobulin (β2-MG), cystatin C (CysC), and retinol binding protein (RBP), were significantly lower in the experimental group than those in the control group (p<0.05). The levels of the inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP) were significantly lower in the experimental group than those in the control group (p<0.05). The levels of 25-hydroxyvitamin D and parathyroid hormone were significantly higher in the experimental group than those in the control group (p<0.05). The level of angiotensin II was lower in the experimental group than that in the control group (p<0.05) and the level of fasting serum insulin was significantly higher in the experimental group than that in the control group (p<0.05). The homeostasis model assessment of insulin resistance (HOMA‑IR) index was lower in the experimental group than that in the control group (p<0.05). The levels of renal function indexes, blood urea nitrogen, creatinine and uric acid, in experimental group were lower than those in control group (p<0.05). The levels of brain derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) were significantly higher in both groups after the intervention than those before the intervention (p<0.05). The levels of BDNF and IGF-1 were higher in the experimental group than that in control group after intervention (p<0.05). The application of alprostadil combined with calcium dobesilate in patients with diabetic nephropathy can effectively relieve clinical symptoms, improve renal functions, reduce blood levels small proteins, alleviate the inflammatory response, and regulate the levels of BDNF and IGF-1, thus improving the clinical treatment effect.
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1 

Hung CC, Lin HY, Hwang DY, Kuo IC, Chiu YW, Lim LM, Hwang SJ and Chen HC: Diabetic retinopathy and clinical parameters favoring the presence of diabetic nephropathy could predict renal outcome in patients with diabetic kidney disease. Sci Rep. 7:12362017. View Article : Google Scholar : PubMed/NCBI

2 

Das F, Ghosh-Choudhury N, Venkatesan B, Kasinath BS and Choudhury Ghosh G: PDGF receptor-β uses Akt/mTORC1 signaling node to promote high glucose-induced renal proximal tubular cell collagen I (α2) expression. Am J Physiol Renal Physiol. 313:F291–F307. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Chen YL, Qiao YC, Xu Y, Ling W, Pan YH, Huang YC, Geng LJ, Zhao HL and Zhang XX: Serum TNF-α concentrations in type 2 diabetes mellitus patients and diabetic nephropathy patients: A systematic review and meta-analysis. Immunol Lett. 186:52–58. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Eissa S, Matboli M and Bekhet MM: Clinical verification of a novel urinary microRNA panal: 133b, −342 and −30 as biomarkers for diabetic nephropathy identified by bioinformatics analysis. Biomed Pharmacother. 83:92–99. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Gnudi L, Coward RJ and Long DA: Diabetic nephropathy: Perspective on novel molecular mechanisms. Trends Endocrinol Metab. 27:820–830. 2016. View Article : Google Scholar : PubMed/NCBI

6 

John S: Complication in diabetic nephropathy. Diabetes Metab Syndr. 10:247–249. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Yun KJ, Kim HJ, Kim MK, Kwon HS, Baek KH, Roh YJ and Song KH: Risk factors for the development and progression of diabetic kidney disease in patients with type 2 diabetes mellitus and advanced diabetic retinopathy. Diabetes Metab J. 40:473–481. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Kubota M, Watanabe R, Yamaguchi M, Hosojima M, Saito A, Fujii M, Fujimura S and Kadowaki M: Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats. Br J Nutr. 116:1326–1335. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Al-Rasheed NM, Al-Rasheed NM, Al-Amin MA, Hasan IH, Al-Ajmi HN, Mohammad RA and Attia HA: Fenofibrate attenuates diabetic nephropathy in experimental diabetic rat's model via suppression of augmented TGF-β1/Smad3 signaling pathway. Arch Physiol Biochem. 122:186–194. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Jose MJ, Varkey V, Chandni R, Zubaida PA and Maliekkal J: The role of smoking as a modifiable risk factor in diabetic nephropathy. J Assoc Physicians India. 64:34–38. 2016.PubMed/NCBI

11 

Liljedahl L, Pedersen MH, Norlin J, McGuire JN and James P: N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models. Clin Proteomics. 13:22–27. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wang M, Yao D, Wang S, Yan Q and Lu W: Long non-coding RNA ENSMUST00000147869 protects mesangial cells from proliferation and fibrosis induced by diabetic nephropathy. Endocrine. 54:81–92. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Ma R, Chaudhari S and Li W: Canonical transient receptor potential 6 channel: A new target of reactive oxygen species in renal physiology and pathology. Antioxid Redox Signal. 25:732–748. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Hanefeld M, Appelt D, Engelmann K, Sandner D, Bornstein SR, Ganz X, Henkel E, Haase R and Birkenfeld AL: Serum and plasma levels of vascular endothelial growth factors in relation to quality of glucose control, biomarkers of inflammation, and diabetic nephropathy. Horm Metab Res. 48:6202016. View Article : Google Scholar : PubMed/NCBI

15 

Ge J, Miao JJ, Sun XY and Yu JY: Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, improves diabetic nephropathy via activating peroxisome proliferator-activated receptor (PPAR)-α/γ and attenuating endoplasmic reticulum stress in rats. J Ethnopharmacol. 189:238–249. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Kang YS, Lee MH, Song HK, Kim JE, Ghee JY, Cha JJ, Lee JE, Kim HW, Han JY and Cha DR: Chronic administration of visfatin ameliorated diabetic nephropathy in type 2 diabetic mice. Kidney Blood Press Res. 41:311–324. 2016. View Article : Google Scholar : PubMed/NCBI

17 

You YK, Huang XR, Chen HY, Lyu XF, Liu HF and Lan HY: C-reactive protein promotes diabetic kidney disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway. Sci Rep. 6:267402016. View Article : Google Scholar : PubMed/NCBI

18 

Ji ZZ and Xu YC: Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model. Mol Med Rep. 14:920–926. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Lu Y, Tang L, Li Y and He Q: High glucose-induced fibronectin upregulation in cultured mesangial cells involves caveolin-1-dependent RhoA-GTP activation via Src kinase. Mol Med Rep. 14:963–968. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Misra A and Shrivastava U: Obstructive sleep apnea and diabetic nephropathy. Diabetes Technol Ther. 18:405–407. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qin L, Qin W, Wang J and Lin L: Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate. Exp Ther Med 14: 5012-5016, 2017.
APA
Qin, L., Qin, W., Wang, J., & Lin, L. (2017). Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate. Experimental and Therapeutic Medicine, 14, 5012-5016. https://doi.org/10.3892/etm.2017.5115
MLA
Qin, L., Qin, W., Wang, J., Lin, L."Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate". Experimental and Therapeutic Medicine 14.5 (2017): 5012-5016.
Chicago
Qin, L., Qin, W., Wang, J., Lin, L."Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5012-5016. https://doi.org/10.3892/etm.2017.5115
Copy and paste a formatted citation
x
Spandidos Publications style
Qin L, Qin W, Wang J and Lin L: Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate. Exp Ther Med 14: 5012-5016, 2017.
APA
Qin, L., Qin, W., Wang, J., & Lin, L. (2017). Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate. Experimental and Therapeutic Medicine, 14, 5012-5016. https://doi.org/10.3892/etm.2017.5115
MLA
Qin, L., Qin, W., Wang, J., Lin, L."Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate". Experimental and Therapeutic Medicine 14.5 (2017): 5012-5016.
Chicago
Qin, L., Qin, W., Wang, J., Lin, L."Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5012-5016. https://doi.org/10.3892/etm.2017.5115
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