Open Access

Effects of activated carbon N‑acetylcysteine sustained‑release microcapsule on dipeptidyl peptidase IV expression in young rats with non‑alcoholic fatty liver disease

  • Authors:
    • Hongping Zhou
    • Tingting Shi
    • Jun Yan
    • Xiaojin Chen
    • Li Liao
    • Shiyong Zhao
    • Hongying Fang
    • Rangxiao Zhuang
  • View Affiliations

  • Published online on: September 19, 2017     https://doi.org/10.3892/etm.2017.5128
  • Pages: 4737-4744
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑alcoholic fatty liver disease (NAFLD) in children has become the most common liver disease influencing adolescent health and one of the most influencing chronic liver diseases among children in Chinese wealthy families, particularly in coastal regions. However, the medicine available for the treatment of NAFLD is deficient. In order to solve this problem, our team studied the activated carbon N‑acetylcysteine (NAC) sustained‑release microcapsule, which improves the oxidation resistance, bioavailability and drug stability of acetylcysteine and reduces toxic and side effects. In addition, it accords with the characteristics of medication in infants and children. The present study mainly discusses whether the activated carbon NAC sustained‑release microcapsule has effects on dipeptidyl peptidase IV (DPPIV) activity and protein in young rats with NAFLD, and whether it has the effect of an DPPIV inhibitor, hoping to provide new thoughts and methods with respect of basic studies on young rats with NAFLD/non‑alcoholic steatohepatitis.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou H, Shi T, Yan J, Chen X, Liao L, Zhao S, Fang H and Zhuang R: Effects of activated carbon N‑acetylcysteine sustained‑release microcapsule on dipeptidyl peptidase IV expression in young rats with non‑alcoholic fatty liver disease. Exp Ther Med 14: 4737-4744, 2017.
APA
Zhou, H., Shi, T., Yan, J., Chen, X., Liao, L., Zhao, S. ... Zhuang, R. (2017). Effects of activated carbon N‑acetylcysteine sustained‑release microcapsule on dipeptidyl peptidase IV expression in young rats with non‑alcoholic fatty liver disease. Experimental and Therapeutic Medicine, 14, 4737-4744. https://doi.org/10.3892/etm.2017.5128
MLA
Zhou, H., Shi, T., Yan, J., Chen, X., Liao, L., Zhao, S., Fang, H., Zhuang, R."Effects of activated carbon N‑acetylcysteine sustained‑release microcapsule on dipeptidyl peptidase IV expression in young rats with non‑alcoholic fatty liver disease". Experimental and Therapeutic Medicine 14.5 (2017): 4737-4744.
Chicago
Zhou, H., Shi, T., Yan, J., Chen, X., Liao, L., Zhao, S., Fang, H., Zhuang, R."Effects of activated carbon N‑acetylcysteine sustained‑release microcapsule on dipeptidyl peptidase IV expression in young rats with non‑alcoholic fatty liver disease". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4737-4744. https://doi.org/10.3892/etm.2017.5128