Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer

  • Authors:
    • Ninglu Yuan
    • Xiaohe Zhang
    • Yonghui Cao
    • Xiaojie Jiang
    • Si Zhao
    • Yingying Feng
    • Yimeng Fan
    • Zhitao Lu
    • Hongmei Gao
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050011, P.R. China, Department of Cardiothoracic Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050011, P.R. China, Department of Computerized Tomography, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 5063-5068
    |
    Published online on: September 19, 2017
       https://doi.org/10.3892/etm.2017.5140
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Non‑small cell lung cancer (NSCLC) is a major cause of morbidity and mortality, and patients with NSCLC are frequently diagnosed at an advanced stage. This is primarily due to a lack of advanced and sensitive protocols for the detection of early stage NSCLC. Therefore, methods for the accurate diagnosis of early stage NSCLC are urgently required to improve survival rates. The present study investigated the use of contrast‑enhanced computerized tomography (CECT) combined with a targeted nanoparticle contrast agent (TNCA) to diagnose early‑stage NSCLC in a mice xenograft model. The TNCA used was lenvatinib, a multi‑target tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor 1‑3, fibroblast growth factor receptor 1‑4, platelet‑derived growth factor receptor β, proto‑oncogene tyrosine‑protein kinase receptor Ret and mast/stem cell growth factor receptor Kit. Xenograft NSCLC mice were established and used to analyze the efficacy of CECT‑TNCA compared with CT scanning alone. The TNCA was inhaled with the use of an atomizer. The results demonstrated that CECT‑TNCA improved the sensitivity of the diagnosis of early stage NSCLC. In addition, imaging using the TNCA enabled the visualization of nodules in the lung in mice with early stage NSCLC. In addition, lung nodule signal enhancement was increased in CECT‑TNCA compared with CT, suggesting a high accurate accumulation of the TNCA in tumor nodules. Mice diagnosed with early stage NSCLC exhibited a higher eradication rate of NSCLC after treatment with cisplatin compared with mice with advanced stage NSCLC. These data indicate that the sensitivity and accuracy of CT imaging for the diagnosis of early stage NSCLC was improved through combination with the liposome‑encapsulated TNCA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

van der Wekken AJ, Saber A, Hiltermann TJ, Kok K, van den Berg A and Groen HJ: Resistance mechanisms after tyrosine kinase inhibitors afatinib and crizotinib in non-small cell lung cancer, a review of the literature. Crit Rev Oncol Hematol. 100:107–116. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Joseph SS, Yentz SE, Mikkilineni S, Nelson C and Kalemkerian GP: Eyelid metastasis in non-small cell lung cancer: Diagnosis and management. Am J Med. 129:e169–e172. 2016. View Article : Google Scholar : PubMed/NCBI

3 

DeCotiis C, Hu Y, Greenberg AK, Huie M, Tsay JC, Pass H, Goldberg JD and Rom WN: Inflammatory cytokines and non-small cell lung cancer in a CT-scan screening cohort: Background review of the literature. Cancer Biomark. 16:219–233. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Kepka L and Socha J: PET-CT use and the occurrence of elective nodal failure in involved field radiotherapy for non-small cell lung cancer: A systematic review. Radiother Oncol. 115:151–156. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Morinaga R, Okamoto I, Furuta K, Kawano Y, Sekijima M, Dote K, Satou T, Nishio K, Fukuoka M and Nakagawa K: Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation. Lung Cancer. 58:411–413. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Khreish F, Hellwig D, Mathews J, Bücker A, Kirsch CM and Grgic A: Simultaneous occurrence of typical carcinoid and non-small-cell lung cancer in the same lung lobe: Value of nuclear medicine. Clin Nucl Med. 36:481–483. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Targowski T, Janda P, Owczarek W, Raczka A, Jahnz-Rózyk K and Plusa T: Evaluation of occurrence frequency of circulating p53 protein in serum of patients with chronic obstructive pulmonary diseases and non-small cell lung cancer. Pol Merkur Lekarski. 28:265–267. 2010.(In Polish). PubMed/NCBI

8 

Xie FJ, Lu HY, Zheng QQ, Qin J, Gao Y, Zhang YP, Hu X and Mao WM: The clinical pathological characteristics and prognosis of FGFR1 gene amplification in non-small-cell lung cancer: A meta-analysis. Onco Targets and Ther. 9:171–181. 2016. View Article : Google Scholar

9 

Moro-Sibilot D, Smit E, de Castro Carpeno J, Lesniewski-Kmak K, Aerts JG, Villatoro R, Kraaij K, Nacerddine K, Dyachkova Y, Smith KT, et al: Non-small cell lung cancer patients with brain metastases treated with first-line platinum-doublet chemotherapy: Analysis from the European FRAME study. Lung Cancer. 90:427–432. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Lim SH, Sun JM, Lee SH, Ahn JS, Park K and Ahn MJ: Pembrolizumab for the treatment of non-small cell lung cancer. Expert Opin Biol Ther. 16:397–406. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Ulivi P, Mercatali L, Casoni GL, Scarpi E, Bucchi L, Silvestrini R, Sanna S, Monteverde M, Amadori D, Poletti V and Zoli W: Multiple marker detection in peripheral blood for NSCLC diagnosis. PloS One. 8:e574012013. View Article : Google Scholar : PubMed/NCBI

12 

Mroczko B, Szmitkowski M and Czygier M: Granulocyte colony stimulating factor (G-CSF) in diagnosis and monitoring of non-small-cell lung cancer (NSCLC). Pol Arch Med Wewn. 103:163–168. 2000.(In Polish). PubMed/NCBI

13 

Muller B, Bovet M, Yin Y, Stichel D, Malz M, González-Vallinas M, Middleton A, Ehemann V, Schmitt J, Muley T, et al: Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells. J Pathol. 237:390–401. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Zhao Q, Yue J, Zhang C, Gu X, Chen H and Xu L: Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC). Oncotarget. 6:29335–29346. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Kim DS, Park KM, Won YS, Kim JY, Lee JK, Kim JG, Oh ST, Jung SS and Kang WK: Occurrence and prognosis of symptomatic venous thromboembolism in colorectal cancer surgery patients. Vasc Specialist Int. 30:49–55. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Thunnissen E, Kerr KM, Herth FJ, Lantuejoul S, Papotti M, Rintoul RC, Rossi G, Skov BG, Weynand B, Bubendorf L, et al: The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group. Lung Cancer. 76:1–18. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Geng J, Sun J, Lin Q, Gu J, Zhao Y, Zhang H, Feng X, He Y, Wang W, Zhou X and Yu J: Methylation status of NEUROG2 and NID2 improves the diagnosis of stage I NSCLC. Oncol Lett. 3:901–906. 2012.PubMed/NCBI

18 

Peters S, Adjei AA, Gridelli C, Reck M, Kerr K and Felip E: ESMO Guidelines Working Group: Metastatic non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 23 Suppl 7:vii56–vii64. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Jafri SH, Shi R and Mills G: Advance lung cancer inflammation index (ALI) at diagnosis is a prognostic marker in patients with metastatic non-small cell lung cancer (NSCLC): A retrospective review. BMC Cancer. 13:1582013. View Article : Google Scholar : PubMed/NCBI

20 

Vilmar AC, Santoni-Rugiu E and Sørensen JB: ERCC1 and histopathology in advanced NSCLC patients randomized in a large multicenter phase III trial. Ann Oncol. 21:1817–1824. 2010. View Article : Google Scholar : PubMed/NCBI

21 

National Lung Screening Trial Research Team, . Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM and Sicks JD: Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 365:395–409. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Saldias PF, Díaz PJ, Rain MC, Illanes CP, Díaz TR and Díaz PO: Early detection of lung cancer using computed tomography among patients with chronic obstructive pulmonary disease. Rev Med Chil. 144:202–210. 2016.(In Spanish). PubMed/NCBI

23 

Rubin GD: Lung nodule and cancer detection in computed tomography screening. J Thorac Imaging. 30:130–138. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Seigneurin A, Field JK, Gachet A and Duffy SW: A systematic review of the characteristics associated with recall rates, detection rates and positive predictive values of computed tomography screening for lung cancer. Ann Oncol. 25:781–791. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Sudarski S, Henzler T and Schoenberg SO: Post-therapeutic positron emission tomography/computed tomography for early detection of non-small cell lung cancer recurrence. Transl Lung Cancer Res. 2:295–303. 2013.PubMed/NCBI

26 

Hagberg GE, Mamedov I, Power A, Beyerlein M, Merkle H, Kiselev VG, Dhingra K, Kubìček V, Angelovski G and Logothetis NK: Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex. Contrast Media Mol Imaging. 9:71–82. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Turetschek K, Preda A, Novikov V, Brasch RC, Weinmann HJ, Wunderbaldinger P and Roberts TP: Tumor microvascular changes in antiangiogenic treatment: Assessment by magnetic resonance contrast media of different molecular weights. J Magn Reson Imaging. 20:138–144. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Samei E, Saunders RS, Badea CT, Ghaghada KB, Hedlund LW, Qi Y, Yuan H, Bentley RC and Mukundan S Jr: Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent. Int J Nanomedicine. 4:277–282. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Palekar RU, Jallouk AP, Lanza GM, Pan H and Wickline SA: Molecular imaging of atherosclerosis with nanoparticle-based fluorinated MRI contrast agents. Nanomedicine (Lond). 10:1817–1832. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Oghabian MA and Farahbakhsh NM: Potential use of nanoparticle based contrast agents in MRI: A molecular imaging perspective. J Biomed Nanotechnol. 6:203–213. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Cho EC, Glaus C, Chen J, Welch MJ and Xia Y: Inorganic nanoparticle-based contrast agents for molecular imaging. Trends Mol Med. 16:561–573. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Nakamoto Y, Ishimori T, Sano K, Temma T, Ueda M, Saji H and Togashi K: Clinical efficacy of dual-phase scanning using (68)Ga-DOTATOC-PET/CT in the detection of neuroendocrine tumours. Clin Radiol. 71:1069.e1–e5. 2016. View Article : Google Scholar

33 

Chen CL, Hu GY, Mei Q, Qiu H, Long GX and Hu GQ: Epidermal growth factor receptor-targeted ultra-small superparamagnetic iron oxide particles for magnetic resonance molecular imaging of lung cancer cells in vitro. Chin Med J (Engl). 125:2322–2328. 2012.PubMed/NCBI

34 

Yasugi M, Takigawa N, Ochi N, Ohashi K, Harada D, Ninomiya T, Murakami T, Honda Y, Ichihara E, Tanimoto M and Kiura K: Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors. Exp Cell Res. 326:201–209. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Fenton-Ambrose L and Kazerooni EA: Preventative care: Lung-cancer screens now worth the cost. Nature. 514:352014. View Article : Google Scholar : PubMed/NCBI

36 

Kulkarni S, Vella ET, Coakley N, Cheng S, Gregg R, Ung YC and Ellis PM: The use of systemic treatment in the maintenance of patients with non-small cell lung cancer: A systematic review. J Thorac Oncol. 11:989–1002. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Yoshiba S, Jansen M, Matsushima N, Chen S and Mendell J: Population pharmacokinetic analysis of patritumab, a HER3 inhibitor, in subjects with advanced non-small cell lung cancer (NSCLC) or solid tumors. Cancer Chemother Pharmacol. 77:987–996. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Weller A, O'Brien ME, Ahmed M, Popat S, Bhosle J, McDonald F, Yap TA, Du Y, Vlahos I and deSouza NM: Mechanism and non-mechanism based imaging biomarkers for assessing biological response to treatment in non-small cell lung cancer. Eur J Cancer. 59:65–78. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Kim SH, Cho BC, Choi HJ, Chung KY, Kim DJ, Park MS, Kim SK, Chang J, Shin SJ, Sohn JH and Kim JH: The number of residual metastatic lymph nodes following neoadjuvant chemotherapy predicts survival in patients with stage III NSCLC. Lung Cancer. 60:393–400. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Satouchi M, Negoro S, Funada Y, Urata Y, Shimada T, Yoshimura S, Kotani Y, Sakuma T, Watanabe H, Adachi S, et al: Predictive factors associated with prolonged survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib. Br J Cancer. 96:1191–1196. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Soldan K, Pooley FD, Hansen J, Andersen A, Chang-Claude J, Ferro G, Ohgaki H, Skov BG, Cherrie JW, Saracci R and Boffetta P: Lung fibre burden in lung cancer cases employed in the rock and slag wool industry. Ann Occup Hyg. 50:241–248. 2006.PubMed/NCBI

42 

Garcia Duenas OF, Villanueva Kerckoff H, Olvera Rico H and Plascencia Lira J: Benign peritoneal cystic mesothelioma as differential diagnose of an ovarian dependant tumor. Case report and review of the literature. Ginecol Obstet Mex. 75:111–114. 2007.(In Spanish). PubMed/NCBI

43 

Garg PK, Deo SV, Kumar R, Shukla NK, Thulkar S, Gogia A, Sharma DN and Mathur SR: Staging PET-CT scanning provides superior detection of lymph nodes and distant metastases than traditional imaging in locally advanced breast cancer. World J Surg. 40:2036–2042. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Nogami Y, Banno K, Irie H, Iida M, Masugi Y, Murakami K and Aoki D: Efficacy of 18-FDG PET-CT dual-phase scanning for detection of lymph node metastasis in gynecological cancer. Anticancer Res. 35:2247–2253. 2015.PubMed/NCBI

45 

Davison CA, Chapman SE, Sasser TA, Wathen C, Diener J, Schafer ZT and Leevy WM: Multimodal optical, X-ray CT and SPECT imaging of a mouse model of breast cancer lung metastasis. Curr Mol Med. 13:368–376. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Genestreti G, Burgio MA, Matteucci F, Piciucchi S, Scarpi E, Monti M, Bucchi L, Parisi E, Crociani L, Gurioli C, et al: Endobronchial/Endoesophageal Ultrasound (EBUS/EUS) guided fine needle aspiration (FNA) and 18F-FDG PET/CT scanning in restaging of locally advanced non-small cell lung cancer (NSCLC) Treated with Chemo-radiotherapy: A Mono-institutional pilot experience. Technol Cancer Res Treat. 14:721–727. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Manowitz A, Sedlar M, Griffon M, Miller A, Miller J and Markowitz S: Use of BMI guidelines and individual dose tracking to minimize radiation exposure from low-dose helical chest CT scanning in a lung cancer screening program. Acad Radiol. 19:84–88. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Rini BI and Atkins MB: Resistance to targeted therapy in renal-cell carcinoma. Lancet Oncol. 10:992–1000. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Eichelberg C, Junker K, Ljungberg B and Moch H: Diagnostic and prognostic molecular markers for renal cell carcinoma: A critical appraisal of the current state of research and clinical applicability. Eur Urol. 55:851–863. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Hutson TE: Targeted therapies for the treatment of metastatic renal cell carcinoma: Clinical evidence. Oncologist. 16 Suppl 2:S14–S22. 2011. View Article : Google Scholar

51 

Nishio M, Horai T, Horiike A, Nokihara H, Yamamoto N, Takahashi T, Murakami H, Yamamoto N, Koizumi F, Nishio K, et al: Phase 1 study of lenvatinib combined with carboplatin and paclitaxel in patients with non-small-cell lung cancer. Br J Cancer. 109:538–544. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Achenbach S, Paul JF, Laurent F, Becker HC, Rengo M, Caudron J, Leschka S, Vignaux O, Knobloch G, Benea G, et al: Erratum to: Comparative assessment of image quality for coronary CT angiography with iobitridol and two contrast agents with higher iodine concentrations: Iopromide and iomeprol. A multicentre randomized double-blind trial. Eur Radiol. 27:8312017. View Article : Google Scholar : PubMed/NCBI

53 

Mannheim JG, Schlichthaerle T, Kuebler L, Quintanilla-Martinez L, Kohlhofer U, Kneilling M and Pichler BJ: Comparison of small animal CT contrast agents. Contrast Media Mol Imaging. 11:272–284. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Honoris L, Zhong Y, Chu E, Rosenthal D, Li D, Lam F and Budoff MJ: Comparison of contrast enhancement, image quality and tolerability in Coronary CT angiography using 4 contrast agents: A prospective randomized trial. Int J Cardiol. 186:126–128. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yuan N, Zhang X, Cao Y, Jiang X, Zhao S, Feng Y, Fan Y, Lu Z and Gao H: Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer. Exp Ther Med 14: 5063-5068, 2017.
APA
Yuan, N., Zhang, X., Cao, Y., Jiang, X., Zhao, S., Feng, Y. ... Gao, H. (2017). Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer. Experimental and Therapeutic Medicine, 14, 5063-5068. https://doi.org/10.3892/etm.2017.5140
MLA
Yuan, N., Zhang, X., Cao, Y., Jiang, X., Zhao, S., Feng, Y., Fan, Y., Lu, Z., Gao, H."Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer". Experimental and Therapeutic Medicine 14.5 (2017): 5063-5068.
Chicago
Yuan, N., Zhang, X., Cao, Y., Jiang, X., Zhao, S., Feng, Y., Fan, Y., Lu, Z., Gao, H."Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5063-5068. https://doi.org/10.3892/etm.2017.5140
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan N, Zhang X, Cao Y, Jiang X, Zhao S, Feng Y, Fan Y, Lu Z and Gao H: Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer. Exp Ther Med 14: 5063-5068, 2017.
APA
Yuan, N., Zhang, X., Cao, Y., Jiang, X., Zhao, S., Feng, Y. ... Gao, H. (2017). Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer. Experimental and Therapeutic Medicine, 14, 5063-5068. https://doi.org/10.3892/etm.2017.5140
MLA
Yuan, N., Zhang, X., Cao, Y., Jiang, X., Zhao, S., Feng, Y., Fan, Y., Lu, Z., Gao, H."Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer". Experimental and Therapeutic Medicine 14.5 (2017): 5063-5068.
Chicago
Yuan, N., Zhang, X., Cao, Y., Jiang, X., Zhao, S., Feng, Y., Fan, Y., Lu, Z., Gao, H."Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5063-5068. https://doi.org/10.3892/etm.2017.5140
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team