Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats

  • Authors:
    • Xiaowei Wang
    • Liaobin Chen
    • Wei Peng
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Anesthesiology, Hospital of Stomatology Wuhan University, Wuhan, Hubei 430079, P.R. China
  • Pages: 5032-5038
    |
    Published online on: September 20, 2017
       https://doi.org/10.3892/etm.2017.5147
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine the protective effects of resveratrol on a rat model of osteoporosis and examine the associated mechanisms of its action. Rats were randomized into the following groups: Control, osteoporosis, osteoporosis + low‑dose resveratrol, osteoporosis + middle‑dose resveratrol and osteoporosis + high‑dose resveratrol groups. Resveratrol treatment was administered 7 days after surgery for 8 weeks. ELISA assay was used to analyze alkaline phosphatase (ALP) and osteocalcin (OC) protein levels. Western blotting was performed to assess the protein expression of sirtuin 1 (SIRT1), nuclear factor (NF)‑κB and NF‑κB inhibitor (IkB) α. In the present study, the results indicated that resveratrol markedly improved the bone mineral density value, femoral porosity and bone mechanical tests in osteoporosis rats. Administration of resveratrol significantly decreased the serum levels of ALP and OC in rats with osteoporosis. Finally, treatment with resveratrol significantly promoted the protein expression of SIRT1, suppressed NF‑κB and activated the IkBα protein expression in rats with osteoporosis. In conclusion, treatment with resveratrol significantly improved the final body weight of the osteoporosis rats via the SIRT1‑NF‑κB signaling pathway. The present study suggested that resveratrol exerted a protective effect on osteoporosis through activation of the SIRT1‑NF‑κB signaling pathway in rats.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Mattei TA, Rehman AA, Issawi A and Fassett DR: Surgical challenges in the management of cervical kyphotic deformity in patients with severe osteoporosis: An illustrative case of a patient with Hajdu-Cheney syndrome. Eur Spine J. 24:2746–2753. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Ohtori S, Akazawa T, Murata Y, Kinoshita T, Yamashita M, Nakagawa K, Inoue G, Nakamura J, Orita S, Ochiai N, et al: Risedronate decreases bone resorption and improves low back pain in postmenopausal osteoporosis patients without vertebral fractures. J Clin Neurosci. 17:209–213. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Otrock ZK, Azar ST, Shamseddeen WA, Habr D, Inati A, Koussa S, Mahfouz RA and Taher AT: Intravenous zoledronic acid treatment in thalassemia-induced osteoporosis: Results of a phase II clinical trial. Ann Hematol. 85:605–609. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Bastian L, Schils F, Tillman JB and Fueredi G: SCORE Investigators: A randomized trial comparing 2 techniques of balloon kyphoplasty and curette use for obtaining vertebral body height restoration and angular-deformity correction in vertebral compression fractures due to osteoporosis. AJNR Am J Neuroradiol. 34:666–675. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Jiang Y, Zeng Y, Huang X, Qin Y, Luo W, Xiang S, Sooranna SR and Pinhu L: Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model. Am J Physiol Lung Cell Mol Physiol. 311:L1023–L1035. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Dvir-Ginzberg M and Steinmeyer J: Towards elucidating the role of SirT1 in osteoarthritis. Front Biosci (Landmark Ed). 18:343–355. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Bai B, Vanhoutte PM and Wang Y: Loss-of-SIRT1 function during vascular ageing: Hyperphosphorylation mediated by cyclin-dependent kinase 5. Trends Cardiovasc Med. 24:81–84. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Jung-Hynes B and Ahmad N: SIRT1 controls circadian clock circuitry and promotes cell survival: A connection with age-related neoplasms. FASEB J. 23:2803–2809. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Javkhedkar AA and Banday AA: Antioxidant resveratrol restores renal sodium transport regulation in SHR. Physiol Rep. 3:pii: e12618. 2015. View Article : Google Scholar : PubMed/NCBI

10 

McGill MR, Du K, Weemhoff JL and Jaeschke H: Critical review of resveratrol in xenobiotic-induced hepatotoxicity. Food Chem Toxicol. 86:309–318. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Shankar S, Singh G and Srivastava RK: Chemoprevention by resveratrol: Molecular mechanisms and therapeutic potential. Front Biosci. 12:4839–4854. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Zhao L, Wang Y, Wang Z, Xu Z, Zhang Q and Yin M: Effects of dietary resveratrol on excess-iron-induced bone loss via antioxidative character. J Nutr Biochem. 26:1174–1182. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Szkudelski T and Szkudelska K: Resveratrol and diabetes: From animal to human studies. Biochim Biophys Acta. 1852:1145–1154. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Lee JH, Kim JS, Park SY and Lee YJ: Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1. Oncol Rep. 35:524–529. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Kumar S, Eroglu E, Stokes JA III, Scissum-Gunn K, Saldanha SN, Singh UP, Manne U, Ponnazhagan S and Mishra MK: Resveratrol induces mitochondria-mediated, caspase-independent apoptosis in murine prostate cancer cells. Oncotarget. 8:20895–20908. 2017.PubMed/NCBI

16 

Lopez MS, Dempsey RJ and Vemuganti R: Resveratrol neuroprotection in stroke and traumatic CNS injury. Neurochem Int. 89:75–82. 2015. View Article : Google Scholar : PubMed/NCBI

17 

de Ligt M, Timmers S and Schrauwen P: Resveratrol and obesity: Can resveratrol relieve metabolic disturbances? Biochim Biophys Acta. 1852:1137–1144. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Ozcicek A, Cetin N, Cimen Keskin F, Tumkaya L, Malkoc I, Gulaboglu M, Yarali O and Suleyman B: The impact of resveratrol on oxidative stress induced by methotrexate in rat ileum tissue: Evaluation of biochemical and histopathological features and analysis of gene expression. Med Princ Pract. 25:181–186. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Mathavan N, Bosemark P, Isaksson H and Tägil M: Investigating the synergistic efficacy of BMP-7 and zoledronate on bone allografts using an open rat osteotomy model. Bone. 56:440–448. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Khajuria DK, Razdan R, Mahapatra DR and Bhat MR: Osteoprotective effect of propranolol in ovariectomized rats: A comparison with zoledronic acid and alfacalcidol. J Orthop Sci. 18:832–842. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Gamsjaeger S, Buchinger B, Zwettler E, Recker R, Black D, Gasser JA, Eriksen EF, Klaushofer K and Paschalis EP: Bone material properties in actively bone-forming trabeculae in postmenopausal women with osteoporosis after three years of treatment with once-yearly Zoledronic acid. J Bone Miner Res. 26:12–18. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Haines CJ, Chung TK, Leung PC, Hsu SY and Leung DH: Calcium supplementation and bone mineral density in postmenopausal women using estrogen replacement therapy. Bone. 16:529–531. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Wang T, Pang L, Huang H and Wang WY: Observation on influence of bone metabolism biochemical indices of senile osteoporosis treated with distant acupuncture and nearby tuina. Zhongguo Zhen Jiu. 32:13–16. 2012.(In Chinese). PubMed/NCBI

24 

Pedraza CE, Marelli B, Chicatun F, McKee MD and Nazhat SN: An in vitro assessment of a cell-containing collagenous extracellular matrix-like scaffold for bone tissue engineering. Tissue Eng Part A. 16:781–793. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Reid JW, Pietak A, Sayer M, Dunfield D and Smith TJ: Phase formation and evolution in the silicon substituted tricalcium phosphate/apatite system. Biomaterials. 26:2887–2897. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Levaot N, Simoncic PD, Dimitriou ID, Scotter A, La Rose J, Ng AH, Willett TL, Wang CJ, Janmohamed S, Grynpas M, et al: 3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions. J Clin Invest. 121:3244–3257. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Nowwarote N, Osathanon T, Jitjaturunt P, Manopattanasoontorn S and Pavasant P: Asiaticoside induces type I collagen synthesis and osteogenic differentiation in human periodontal ligament cells. Phytother Res. 27:457–462. 2013. View Article : Google Scholar : PubMed/NCBI

28 

He N, Zhu X, He W, Zhao S, Zhao W and Zhu C: Resveratrol inhibits the hydrogen dioxide-induced apoptosis via Sirt 1 activation in osteoblast cells. Biosci Biotechnol Biochem. 79:1779–1786. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Shakibaei M, Shayan P, Busch F, Aldinger C, Buhrmann C, Lueders C and Mobasheri A: Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: Potential role of Runx2 deacetylation. PLoS One. 7:e357122012. View Article : Google Scholar : PubMed/NCBI

30 

Saravanan S, Vimalraj S, Vairamani M and Selvamurugan N: Role of mesoporous wollastonite (Calcium Silicate) in mesenchymal stem cell proliferation and osteoblast differentiation: A cellular and molecular study. J Biomed Nanotechnol. 11:1124–1138. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Sin TK, Yung BY, Yip SP, Chan LW, Wong CS, Tam EW and Siu PM: SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression. Front Physiol. 6:2932015. View Article : Google Scholar : PubMed/NCBI

32 

Zhang F, Lu M, Wang H and Ren T: Aspirin attenuates angiotensin II-induced inflammation in bone marrow mesenchymal stem cells via the inhibition of ERK1/2 and NF-κB activation. Biomed Rep. 1:930–934. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Wu CM, Chen PC, Li TM, Fong YC and Tang CH: Si-Wu-tang extract stimulates bone formation through PI3K/Akt/NF-κB signaling pathways in osteoblasts. BMC Complement Altern Med. 13:2772013. View Article : Google Scholar : PubMed/NCBI

34 

Yao Z, Li Y, Yin X, Dong Y, Xing L and Boyce BF: NF-κB RelB negatively regulates osteoblast differentiation and bone formation. J Bone Miner Res. 29:866–877. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Tsubaki M, Takeda T, Kino T, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T and Nishida S: Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β and RANKL through inhibiting the activation of NF-κB and ERK1/2. Am J Transl Res. 7:1371–1381. 2015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang X, Chen L and Peng W: Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats. Exp Ther Med 14: 5032-5038, 2017.
APA
Wang, X., Chen, L., & Peng, W. (2017). Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats. Experimental and Therapeutic Medicine, 14, 5032-5038. https://doi.org/10.3892/etm.2017.5147
MLA
Wang, X., Chen, L., Peng, W."Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats". Experimental and Therapeutic Medicine 14.5 (2017): 5032-5038.
Chicago
Wang, X., Chen, L., Peng, W."Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5032-5038. https://doi.org/10.3892/etm.2017.5147
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Chen L and Peng W: Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats. Exp Ther Med 14: 5032-5038, 2017.
APA
Wang, X., Chen, L., & Peng, W. (2017). Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats. Experimental and Therapeutic Medicine, 14, 5032-5038. https://doi.org/10.3892/etm.2017.5147
MLA
Wang, X., Chen, L., Peng, W."Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats". Experimental and Therapeutic Medicine 14.5 (2017): 5032-5038.
Chicago
Wang, X., Chen, L., Peng, W."Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5032-5038. https://doi.org/10.3892/etm.2017.5147
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team