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Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients

  • Authors:
    • Guangya Wang
    • Guangyao Song
    • Linxia Wang
    • Fang Gao
    • Ningning Guo
    • Yunna Zhang
    • Nairui Zhao
    • Xiuping Yin
  • View Affiliations / Copyright

    Affiliations: Teaching and Research Section of Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Second Department of Endocrinology and Metabolism, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5002-5006
    |
    Published online on: September 20, 2017
       https://doi.org/10.3892/etm.2017.5149
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Abstract

The aim of the present study was to determine the correlation between adiponectin (APN) gene polymorphism, metabolic syndrome incidence, and degree of atherosclerosis in patients with this disease. The study was conducted on 369 unrelated patients, diagnosed with metabolic abnormalities. The patients were divided into the metabolic syndrome group (MS group, n=182), the metabolic abnormality group (n=187) and the control group with metabolic normality (n=134), as per the degree of metabolic abnormality. The gene polymorphism of rs121917815 site of APN gene was detected by TaqMAN probe technique, and the OR values of different genotypes and alleles were calculated. The APN protein, C-reactive protein (CRP), IL-1 and high-density lipoprotein (HDL) 2a and 2b expression level changes were detected by immunoblotting. The atherosclerosis index (AI) of each allele in patients with MS was calculated. Compared with the control group, the expression levels of APN protein in the metabolic abnormality and MS groups were significantly decreased. However, there was no distinct difference in the comparison of gene polymorphism between the control and metabolic abnormality groups. The CC genotype frequency and C allele frequency of rs121917815 polymorphic site in the MS group were significantly increased, compared with the control group. The TT genotype frequency and T allele frequency were significantly decreased and the OR values of the CC genotype and C allele were increased. The results of immunoblotting showed that there was no obvious change of CRP, IL-1, HDL-2a and HDL-2b in the three groups, and there was no statistically significant difference in the comparison of AI between the MS and control groups as well as the metabolic abnormality group. The APN gene polymorphic site rs121917815 is associated with MS. The occurrence of CC genotype and C allele increased the incidence of MS, but it did not increase the degree of atherosclerosis in MS patients.
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1 

Alberti KGM, Zimmet P and Shaw J: IDF Epidemiology Task Force Consensus Group: The metabolic syndrome - a new worldwide definition. Lancet. 366:1059–1062. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Gastrich MD, Lasser NL, Wien M and Bachmann G: Dietary complex carbohydrates and low glycemic index/load decrease levels of specific metabolic syndrome/cardiovascular disease risk factors. Top Clin Nutr. 23:76–96. 2008. View Article : Google Scholar

3 

Kim B and Feldman EL: Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome. Exp Mol Med. 47:e1492015. View Article : Google Scholar : PubMed/NCBI

4 

Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, et al: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 8:1288–1295. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K and Tobe K: Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 116:1784–1792. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Lee S and Kwak HB: Role of adiponectin in metabolic and cardiovascular disease. J Exerc Rehabil. 10:54–59. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Nigro E, Scudiero O, Monaco ML, Palmieri A, Mazzarella G, Costagliola C, Bianco A and Daniele A: New insight into adiponectin role in obesity and obesity-related diseases. Biomed Res Int. 2014:6589132014.https://doi.org/10.1155/2014/658913 View Article : Google Scholar : PubMed/NCBI

8 

Fu Y: Adiponectin signaling and metabolic syndrome. Prog Mol Biol Transl Sci. 121:293–319. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Bouatia-Naji N, Meyre D, Lobbens S, Séron K, Fumeron F, Balkau B, Heude B, Jouret B, Scherer PE, Dina C, et al: ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes. 55:545–550. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Hussain T, Yakout S, Vinodson B and Sabico S: Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population. Gene. 493:142–147. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Cai X, Gan Y, Fan Y, Hu J, Jin Y, Chen F, Chen T, Sun Y, Wang J, Qin W, et al: The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk. Clin Transl Oncol. 16:166–172. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Samson SL and Garber AJ: Metabolic syndrome. Endocrinol Metab Clin North Am. 43:1–23. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yesil A and Yilmaz Y: Review article: Coffee consumption, the metabolic syndrome and non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 38:1038–1044. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, Machicao F and Häring H: Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: Interaction with family history of type 2 diabetes. Diabetes. 51:37–41. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Fredriksson J, Carlsson E, Orho-Melander M, Groop L and Ridderstråle M: A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects. Int J Obes. 30:226–232. 2006. View Article : Google Scholar

16 

Zietz B, Buechler C, Kobuch K, Neumeier M, Schölmerich J and Schäffler A: Serum levels of adiponectin are associated with diabetic retinopathy and with adiponectin gene mutations in Caucasian patients with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes. 116:532–536. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Hutter N, Baena M, Sangüesa G, Dávalos A, Latasa MJ, Escolà-Gil JC, Sánchez RM, Roglans N, Alegret M and Laguna JC: Liquid fructose supplementation in LDL-R−/− mice fed a western-type diet enhances lipid burden and atherosclerosis despite identical calorie consumption. Int J Cardiol. 9:12–21. 2015.

18 

Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, et al: Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res. 56:22–37. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Rudolf J and Lewandrowski KB: Cholesterol, lipoproteins, high-sensitivity c-reactive protein, and other risk factors for atherosclerosis. Clin Lab Med. 34(113–127): vii. 2014.PubMed/NCBI

20 

Parhofer KG: Increasing HDL-cholesterol and prevention of atherosclerosis: A critical perspective. Atheroscler Suppl. 18:109–111. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang G, Song G, Wang L, Gao F, Guo N, Zhang Y, Zhao N and Yin X: Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients. Exp Ther Med 14: 5002-5006, 2017.
APA
Wang, G., Song, G., Wang, L., Gao, F., Guo, N., Zhang, Y. ... Yin, X. (2017). Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients. Experimental and Therapeutic Medicine, 14, 5002-5006. https://doi.org/10.3892/etm.2017.5149
MLA
Wang, G., Song, G., Wang, L., Gao, F., Guo, N., Zhang, Y., Zhao, N., Yin, X."Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients". Experimental and Therapeutic Medicine 14.5 (2017): 5002-5006.
Chicago
Wang, G., Song, G., Wang, L., Gao, F., Guo, N., Zhang, Y., Zhao, N., Yin, X."Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5002-5006. https://doi.org/10.3892/etm.2017.5149
Copy and paste a formatted citation
x
Spandidos Publications style
Wang G, Song G, Wang L, Gao F, Guo N, Zhang Y, Zhao N and Yin X: Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients. Exp Ther Med 14: 5002-5006, 2017.
APA
Wang, G., Song, G., Wang, L., Gao, F., Guo, N., Zhang, Y. ... Yin, X. (2017). Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients. Experimental and Therapeutic Medicine, 14, 5002-5006. https://doi.org/10.3892/etm.2017.5149
MLA
Wang, G., Song, G., Wang, L., Gao, F., Guo, N., Zhang, Y., Zhao, N., Yin, X."Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients". Experimental and Therapeutic Medicine 14.5 (2017): 5002-5006.
Chicago
Wang, G., Song, G., Wang, L., Gao, F., Guo, N., Zhang, Y., Zhao, N., Yin, X."Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5002-5006. https://doi.org/10.3892/etm.2017.5149
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