Open Access

A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice

  • Authors:
    • Hui‑Min Li
    • Ying‑Lu Shi
    • Di Wen
    • Huan‑Min Luo
    • Xi Lin
    • Fei Xiao
  • View Affiliations

  • Published online on: September 21, 2017     https://doi.org/10.3892/etm.2017.5157
  • Pages: 5186-5192
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

There is no effective drug for the therapy of acute carbon monoxide (CO) poisoning. The purpose of the present study was to investigate the potential preventive and therapeutic effects of hemin on an animal model of acute CO poisoning and to provide a potential therapeutic candidate drug. A total of 80 Kunming mice were randomly divided into four groups, namely the air control, acute CO poisoning, hemin‑treatment + CO and hemin‑pretreatment + CO groups (n=20 each). Furthermore, the mortality rate of mice, blood carboxyhaemoglobin (HbCO) concentration and serum malondialdehyde (MDA) concentration were measured, and pathological changes of the hippocampal area were determined using histochemical staining. The mice with acute CO poisoning had a 50% mortality rate at 1 h, with an increase in blood HbCO, serum MDA levels and pathological impairments of the hippocampus. Furthermore, the mortality rate, blood HbCO and serum MDA levels of mice with pretreatment and treatment of hemin were decreased. Additionally, the pathological changes of the hippocampal area were improved in the hemin‑treatment and hemin‑pretreatment groups compared with the mice treated with CO. These results suggest that hemin is a novel effective chemical for the prevention and treatment of acute CO poisoning in mice. Therefore, the present study provides a novel method and experimental basis for the application of hemin in treating patients with acute CO poisoning.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li HM, Shi YL, Wen D, Luo HM, Lin X and Xiao F: A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice. Exp Ther Med 14: 5186-5192, 2017
APA
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., & Xiao, F. (2017). A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice. Experimental and Therapeutic Medicine, 14, 5186-5192. https://doi.org/10.3892/etm.2017.5157
MLA
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., Xiao, F."A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice". Experimental and Therapeutic Medicine 14.5 (2017): 5186-5192.
Chicago
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., Xiao, F."A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5186-5192. https://doi.org/10.3892/etm.2017.5157