Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice

  • Authors:
    • Hui‑Min Li
    • Ying‑Lu Shi
    • Di Wen
    • Huan‑Min Luo
    • Xi Lin
    • Fei Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China, International School of Clinical Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5186-5192
    |
    Published online on: September 21, 2017
       https://doi.org/10.3892/etm.2017.5157
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

There is no effective drug for the therapy of acute carbon monoxide (CO) poisoning. The purpose of the present study was to investigate the potential preventive and therapeutic effects of hemin on an animal model of acute CO poisoning and to provide a potential therapeutic candidate drug. A total of 80 Kunming mice were randomly divided into four groups, namely the air control, acute CO poisoning, hemin‑treatment + CO and hemin‑pretreatment + CO groups (n=20 each). Furthermore, the mortality rate of mice, blood carboxyhaemoglobin (HbCO) concentration and serum malondialdehyde (MDA) concentration were measured, and pathological changes of the hippocampal area were determined using histochemical staining. The mice with acute CO poisoning had a 50% mortality rate at 1 h, with an increase in blood HbCO, serum MDA levels and pathological impairments of the hippocampus. Furthermore, the mortality rate, blood HbCO and serum MDA levels of mice with pretreatment and treatment of hemin were decreased. Additionally, the pathological changes of the hippocampal area were improved in the hemin‑treatment and hemin‑pretreatment groups compared with the mice treated with CO. These results suggest that hemin is a novel effective chemical for the prevention and treatment of acute CO poisoning in mice. Therefore, the present study provides a novel method and experimental basis for the application of hemin in treating patients with acute CO poisoning.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Braubach M, Algoet A, Beaton M, Lauriou S, Héroux ME and Krzyzanowski M: Mortality associated with exposure to carbon monoxide in WHO European Member States. Indoor Air. 23:115–125. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Prockop LD and Chichkova RI: Carbon monoxide intoxication: An updated review. J Neurol Sci. 262:122–130. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, Orme JF Jr, Thomas FO and Morris AH: Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med. 347:1057–1067. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Pace N, Strajman E and Walker EL: Acceleration of carbon monoxide elimination in man by high pressure oxygen. Science. 111:652–654. 1950. View Article : Google Scholar : PubMed/NCBI

5 

Hawkins M, Harrison J and Charters P: Severe carbon monoxide poisoning: Outcome after hyperbaric oxygen therapy. Br J Anaesth. 84:584–586. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Hampson NB and Zmaeff JL: Outcome of patients experiencing cardiac arrest with carbon monoxide poisoning treated with hyperbaric oxygen. Ann Emerg Med. 38:36–41. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Li Q, Song JJ, Zhang HY, Fu K, Lan HB and Deng Y: Dexamethasone therapy for preventing delayed encephalopathy after carbon monoxide poisoning. Biotech Histochem. 90:561–567. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Akyol S, Yuksel S, Pehlivan S, Erdemli HK, Gulec MA, Adam B and Akyol O: Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits. Med Hypotheses. 92:3–6. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Wang H, Li Y, Wu Q, Xu C and Liu Q: Combination of butylphthalide with umbilical mesenchymal stem cells for the treatment of delayed encephalopathy after carbon monoxide poisoning. Medicine (Baltimore). 95:e54122016. View Article : Google Scholar : PubMed/NCBI

10 

Ochi S, Abe M, Li C, Mori Y, Ishimaru T, Yoshino Y, Yamazaki K, Mori T, Fukuhara R, Tanimukai S, et al: The nicotinic cholinergic system is affected in rats with delayed carbon monoxide encephalopathy. Neurosci Lett. 569:33–37. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Hu MC, Shiah IS, Yeh CB, Chen HK and Chen CK: Ziprasidone in the treatment of delayed carbon monoxide encephalopathy. Prog Neuropsychopharmacol Biol Psychiatry. 30:755–757. 2006. View Article : Google Scholar : PubMed/NCBI

12 

O'Bryan EC, Veser FH, Veser B and Casey R: Therapeutic effects of glucagon on carbon monoxide poisoning. Annals Emergency Med. 44:S922004. View Article : Google Scholar

13 

Cuadrado A and Rojo AI: Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr Pharm Des. 14:429–442. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Zhu Y, Sun Y, Jin K and Greenberg DA: Hemin induces neuroglobin expression in neural cells. Blood. 100:2494–2498. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Guan L, Wen T, Zhang Y, Wang X and Zhao J: Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning. Toxicology. 262:146–152. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Fechter LD, Thorne PR and Nuttall AL: Effects of carbon monoxide on cochlear electrophysiology and blood flow. Hear Res. 27:37–45. 1987. View Article : Google Scholar : PubMed/NCBI

17 

Bruce RD: An up-and-down procedure for acute toxicity testing. Fundam Appl Toxicol. 5:151–157. 1985. View Article : Google Scholar : PubMed/NCBI

18 

Hamilton MA, Russo RC and Thurston RV: Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environmental Sci Technol. 11:714–719. 1977. View Article : Google Scholar

19 

Ramieri A Jr, Jatlow P and Seligson D: New method for rapid determination of carboxyhemoglobin by use of double-wavelength spectrophotometry. Clin Chem. 20:278–281. 1974.PubMed/NCBI

20 

Placer ZA, Cushman LL and Johnson BC: Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem. 16:359–364. 1966. View Article : Google Scholar : PubMed/NCBI

21 

Todorova I, Simeonova G, Kyuchukova D, Dinev D and Gadjeva V: Reference values of oxidative stress parameters (MDA, SOD, CAT) in dogs and cats. Comparative Clinical Pathol. 13:190–194. 2005. View Article : Google Scholar

22 

Nabeshima T, Katoh A, Ishimaru H, Yoneda Y, Ogita K, Murase K, Ohtsuka H, Inari K, Fukuta T and Kameyama T: Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice. J Pharmacol Exp Ther. 256:378–384. 1991.PubMed/NCBI

23 

Sidman RL, Angevine JB and Pierce ET: Atlas of the mouse brain and spinal cord. Harvard University Press; Cambridge, Mass: 1971

24 

Raub JA, Mathieu-Nolf M, Hampson NB and Thom SR: Carbon monoxide poisoning-a public health perspective. Toxicology. 145:1–14. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Penney DG: Acute carbon monoxide poisoning: Animal models: A review. Toxicology. 62:123–160. 1990. View Article : Google Scholar : PubMed/NCBI

26 

Lopez DM, Weingarten-Arams JS, Singer LP and Conway EE Jr: Relationship between arterial, mixed venous, and internal jugular carboxyhemoglobin concentrations at low, medium and high concentrations in a piglet model of carbon monoxide toxicity. Crit Care Med. 28:1998–2001. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Fechter LD, Thorne PR and Nuttall AL: Effects of carbon monoxide on cochlear electrophysiology and blood flow. Hear Res. 27:37–45. 1987. View Article : Google Scholar : PubMed/NCBI

28 

Fan Y, Li J, Yin Q, Zhang Y, Xu H, Shi X, Li C, Zhou Y and Zhou C: Effect of extractions from Ephedra sinica Stapf on hyperlipidemia in mice. Exp Ther Med. 9:619–625. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Burmester T, Weich B, Reinhardt S and Hankeln T: A vertebrate globin expressed in the brain. Nature. 407:520–523. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Chen NC, Huang CW, Lui CC, Lee CC, Chang WN, Huang SH, Chen C and Chang CC: Diffusion-weighted imaging improves prediction in cognitive outcome and clinical phases in patients with carbon monoxide intoxication. Neuroradiology. 55:107–115. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Kurauchi Y, Hisatsune A, Isohama Y and Katsuki H: Nitric oxide-cyclic GMP signaling pathway limits inflammatory degeneration of midbrain dopaminergic neurons: Cell type-specific regulation of heme oxygenase-1 expression. Neuroscience. 158:856–866. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Morse D and Choi AM: Heme oxygenase-1: From bench to bedside. Am J Respir Crit Care Med. 172:660–670. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Wu L and Wang R: Carbon monoxide: Endogenous production, physiological functions, and pharmacological applications. Pharmacol Rev. 57:585–630. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Elbirt KK and Bonkovsky HL: Heme oxygenase: Recent advances in understanding its regulation and role. Proc Assoc Am Physicians. 111:pp. 438–447. 1999; PubMed/NCBI

35 

Akyol S, Erdogan S, Idiz N, Celik S, Kaya M, Ucar F, Dane S and Akyol O: The role of reactive oxygen species and oxidative stress in carbon monoxide toxicity: An in-depth analysis. Redox Rep. 19:180–189. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Amemiya S, Kamiya T, Nito C, Inaba T, Kato K, Ueda M, Shimazaki K and Katayama Y: Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J Pharmacol. 516:125–130. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Hampson NB, Simonson SG, Kramer CC and Piantadosi CA: Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning. Undersea Hyperb Med. 23:215–219. 1996.PubMed/NCBI

38 

Ulbrich F and Goebel U: Argon: A novel therapeutic option to treat neuronal ischemia and reperfusion injuries? Neural Regen Res. 10:1043–1044. 2015. View Article : Google Scholar : PubMed/NCBI

39 

O'Donnell P, Buxton PJ, Pitkin A and Jarvis LJ: The magnetic resonance imaging appearances of the brain in acute carbon monoxide poisoning. Clin Radiol. 55:273–280. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li HM, Shi YL, Wen D, Luo HM, Lin X and Xiao F: A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice. Exp Ther Med 14: 5186-5192, 2017.
APA
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., & Xiao, F. (2017). A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice. Experimental and Therapeutic Medicine, 14, 5186-5192. https://doi.org/10.3892/etm.2017.5157
MLA
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., Xiao, F."A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice". Experimental and Therapeutic Medicine 14.5 (2017): 5186-5192.
Chicago
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., Xiao, F."A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5186-5192. https://doi.org/10.3892/etm.2017.5157
Copy and paste a formatted citation
x
Spandidos Publications style
Li HM, Shi YL, Wen D, Luo HM, Lin X and Xiao F: A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice. Exp Ther Med 14: 5186-5192, 2017.
APA
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., & Xiao, F. (2017). A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice. Experimental and Therapeutic Medicine, 14, 5186-5192. https://doi.org/10.3892/etm.2017.5157
MLA
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., Xiao, F."A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice". Experimental and Therapeutic Medicine 14.5 (2017): 5186-5192.
Chicago
Li, H., Shi, Y., Wen, D., Luo, H., Lin, X., Xiao, F."A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5186-5192. https://doi.org/10.3892/etm.2017.5157
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team