Open Access

Serological evaluation of antigen Tp0693 for diagnosis of syphilis

  • Authors:
    • Li Zhang
    • Meixia Deng
    • Xiaohong Zhang
    • Weiguo Yin
    • Wen Liu
    • Xi Luo
    • Jie Yang
    • Fei Chen
    • Feijun Zhao
  • View Affiliations

  • Published online on: September 21, 2017     https://doi.org/10.3892/etm.2017.5158
  • Pages: 4729-4736
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the diagnostic value of the Treponema pallidum (Tp) antigen Tp0693 for syphilis. ELISA was used to examine the serum levels of Tp0693. The sample‑to‑cutoff ratio (S/CO) value was used to generate a receiver operating characteristic (ROC) curve. A correlation analysis was performed to compare the detection efficacy of Tp0693‑specific ELISA, Treponema pallidum Particle Agglutination (TPPA), Tolulized Red Unheated Serum test (TRUST) and LiZhu™ Tp‑ELISA. The area under the ROC curve was 0.99, indicating good diagnostic efficacy. When the diagnostic specificity reached 100%, the diagnostic sensitivity was up to 93.5%. Tp0693‑specific ELISA results were not correlated with those of TPPA, TRUST and LiZhu™ Tp‑ELISA (correlation coefficient, 0.122, 0.114 and 0.025, respectively). The latent syphilis rate was highest (12%, 9/75) for all syphilis specimens with a S/CO in the grey area. In conclusion, for syphilis specimens with a S/CO in the grey area, TPPA should be used for further confirmation of the diagnosis. Tp0693 may be used as a diagnostic antigen for syphilis; however, further study regarding its potential use is required.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang L, Deng M, Zhang X, Yin W, Liu W, Luo X, Yang J, Chen F and Zhao F: Serological evaluation of antigen Tp0693 for diagnosis of syphilis. Exp Ther Med 14: 4729-4736, 2017
APA
Zhang, L., Deng, M., Zhang, X., Yin, W., Liu, W., Luo, X. ... Zhao, F. (2017). Serological evaluation of antigen Tp0693 for diagnosis of syphilis. Experimental and Therapeutic Medicine, 14, 4729-4736. https://doi.org/10.3892/etm.2017.5158
MLA
Zhang, L., Deng, M., Zhang, X., Yin, W., Liu, W., Luo, X., Yang, J., Chen, F., Zhao, F."Serological evaluation of antigen Tp0693 for diagnosis of syphilis". Experimental and Therapeutic Medicine 14.5 (2017): 4729-4736.
Chicago
Zhang, L., Deng, M., Zhang, X., Yin, W., Liu, W., Luo, X., Yang, J., Chen, F., Zhao, F."Serological evaluation of antigen Tp0693 for diagnosis of syphilis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4729-4736. https://doi.org/10.3892/etm.2017.5158