Open Access

Comparison of the effect of rosuvastatin versus rosuvastatin/ezetimibe on markers of inflammation in patients with acute myocardial infarction

  • Authors:
    • Yizhi Ren
    • Hao Zhu
    • Zhongguo Fan
    • Yali Gao
    • Nailiang Tian
  • View Affiliations

  • Published online on: September 21, 2017     https://doi.org/10.3892/etm.2017.5175
  • Pages: 4942-4950
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Statins lower low‑density lipoprotein cholesterol (LDL‑C) and high‑sensitivity C‑reactive protein (hsCRP), and the addition of ezetimibe to statins further reduces LDL‑C and hsCRP. Lipoprotein‑associated phospholipase A2 (Lp‑PLA2) is a potentially important pathogenic factor participating in the progression of atherosclerosis. The aim of current study was to investigate how the addition of ezetimibe to rosuvastatin treatment affects reductions in LDL‑C, hsCRP and Lp‑PLA2 in patients with acute myocardial infarction (AMI). A total of 135 patients were enrolled in the study within 24 h of AMI, and were randomized to receive 10 mg rosuvastatin or 10 mg rosuvastatin plus 10 mg ezetimibe daily. HsCRP, Lp‑PLA2, total cholesterol (TC), triglycerides (TG), LDL‑C and high‑density lipoprotein cholesterol (HDL‑C) were determined at baseline and after 1, 3, 6 and 12 months of treatment. The addition of ezetimibe to rosuvastatin led to greater reduction of LDL‑C compared with rosuvastatin monotherapy (from 3.00 to 1.19 mmol/l vs. 2.93 to 1.49 mmol/l, respectively; P<0.05), as well as reduced levels of hsCRP (from 5.15 to 0.68 mg/l vs. 4.33 to 1.49 mg/l, respectively; P<0.05) and Lp‑PLA2 (from 333.13 to 79.07 mg/l vs. 327.95 to 123.62 mg/l, respectively; P<0.05). A positive association was identified between reductions of Lp‑PLA2 and the changes of LDL‑C (r=0.367; P=0.002). However, no significant correlation was observed between changes in Lp‑PLA2 and hsCRP (r=0.264; P=0.512). The values of hsCRP and Lp‑PLA2 appeared to increase during the first week after randomization, but dropped steeply to a lower level and remained stable thereafter. In conclusion, the addition of ezetimibe to rosuvastatin was demonstrated to further reduce LDL‑C, hsCRP and Lp‑PLA2 compared with rosuvastatin monotherapy in patients with AMI.
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November-2017
Volume 14 Issue 5

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Online ISSN:1792-1015

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Spandidos Publications style
Ren Y, Zhu H, Fan Z, Gao Y and Tian N: Comparison of the effect of rosuvastatin versus rosuvastatin/ezetimibe on markers of inflammation in patients with acute myocardial infarction. Exp Ther Med 14: 4942-4950, 2017
APA
Ren, Y., Zhu, H., Fan, Z., Gao, Y., & Tian, N. (2017). Comparison of the effect of rosuvastatin versus rosuvastatin/ezetimibe on markers of inflammation in patients with acute myocardial infarction. Experimental and Therapeutic Medicine, 14, 4942-4950. https://doi.org/10.3892/etm.2017.5175
MLA
Ren, Y., Zhu, H., Fan, Z., Gao, Y., Tian, N."Comparison of the effect of rosuvastatin versus rosuvastatin/ezetimibe on markers of inflammation in patients with acute myocardial infarction". Experimental and Therapeutic Medicine 14.5 (2017): 4942-4950.
Chicago
Ren, Y., Zhu, H., Fan, Z., Gao, Y., Tian, N."Comparison of the effect of rosuvastatin versus rosuvastatin/ezetimibe on markers of inflammation in patients with acute myocardial infarction". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4942-4950. https://doi.org/10.3892/etm.2017.5175