Insect tea attenuates hydrochloric acid and ethanol‑induced mice acute gastric injury

  • Authors:
    • Xin Zhao
    • Qiang Cheng
    • Yu Qian
    • Ruokun Yi
    • Lianjie Gu
    • Shanshan Wang
    • Jia‑Le Song
  • View Affiliations

  • Published online on: September 22, 2017     https://doi.org/10.3892/etm.2017.5181
  • Pages: 5135-5142
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Abstract

The aim of the present study was to investigate the protective effect of insect tea on HCl/ethanol‑induced gastric ulcers in ICR mice. The serum levels of vasoactive intestinal peptide, substance P, somatostatin, motilin and endothelin‑1 in mice were assessed using commercial kits and gastric tissues of superoxide dismutase (SOD, nitric oxide (NO) and malondialdehyde (MDA) were determined using western blot analysis Insect tea significantly reduced HCl/ethanol‑induced gastric juice secretion and increased the pH of gastric juice (P<0.05). Insect tea treatment signfiicantly increased vasoactive intestinal peptide and somatostatin, and significantly decreased motilin, substance P and endothelin levels in the serum (P<0.05). Treatment with insect tea was demonstrated to significantly increase levels of gastric SOD and NO and to reduce levels of MDA in the gastric ulcer mouse model (P<0.05). The gastric expression of inhibitor of nuclear factor‑κB (NF‑κB), epidermal growth factor (EGF), EGF receptor, neuronal nitric oxide synthase (nNOS), endothelial NOS, Mn‑SOD, Cu/Zn‑SOD and catalase was significantly increased in mice treated with inset tea compared with untreated model mice (P<0.05). Levels of NF‑κB, and inducible NOS were demonstrated to be decreased in mice treated with insect tea compared with untreated model mice (P<0.05). The results of the present study suggest that insect tea has a protective effect against HCl/ethanol‑induced gastric ulcers in ICR mice. This effect may be achieved via modulating serum neuropeptide levels, reducing gastric juice secretion, and modulating the inflammation‑ and antioxidant‑associated protein expressions in gastric tissue.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhao X, Cheng Q, Qian Y, Yi R, Gu L, Wang S and Song JL: Insect tea attenuates hydrochloric acid and ethanol‑induced mice acute gastric injury. Exp Ther Med 14: 5135-5142, 2017
APA
Zhao, X., Cheng, Q., Qian, Y., Yi, R., Gu, L., Wang, S., & Song, J. (2017). Insect tea attenuates hydrochloric acid and ethanol‑induced mice acute gastric injury. Experimental and Therapeutic Medicine, 14, 5135-5142. https://doi.org/10.3892/etm.2017.5181
MLA
Zhao, X., Cheng, Q., Qian, Y., Yi, R., Gu, L., Wang, S., Song, J."Insect tea attenuates hydrochloric acid and ethanol‑induced mice acute gastric injury". Experimental and Therapeutic Medicine 14.5 (2017): 5135-5142.
Chicago
Zhao, X., Cheng, Q., Qian, Y., Yi, R., Gu, L., Wang, S., Song, J."Insect tea attenuates hydrochloric acid and ethanol‑induced mice acute gastric injury". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5135-5142. https://doi.org/10.3892/etm.2017.5181