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Article

Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules

  • Authors:
    • Lili Hu
    • Yuanwei Pan
    • Zhigang Zhou
    • Jianbo Gao
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 5109-5113
    |
    Published online on: September 22, 2017
       https://doi.org/10.3892/etm.2017.5194
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Abstract

The aim of the present study was to investigate the value of positron emission tomography‑computed tomography (PET‑CT) using 18F‑fluorodeoxyglucose in the clinical diagnosis of pulmonary ground‑glass nodule. In total, 54 patients with pulmonary GGN that were identified by PET‑CT examination were selected and confirmed by pathology and clinical diagnosis in hospital between April 2014 and April 2015. The association between PET‑CT findings and pathology, and the value of PET‑CT were then evaluated. In the 54 patients, solitary pulmonary GGN with a nodule diameter of between 0.6 and 2.0 cm were detected. Amongst them, the PET‑CT examination of 42 patients revealed hyper metabolic nodules, and were all mixed GGN type nodules with a diameter >1 cm. The PET‑CT examination of the remaining 12 patients demonstrated no evidence of metabolic abnormalities and the nodules in these patients were pure or mixed GGN with a diameter <1 cm (except 2 cases with a diameter ≥1 cm). Furthermore, the diagnoses for all patients were pathologically confirmed by CT‑guided needle biopsy or thoracoscopic surgical resection. Amongst them, there were 41 cases of lung adenocarcinoma, 4 cases of fungal infection, 7 cases of inflammation and 2 cases of adenomatoid hyperplasia. Additionally, PET‑CT has a lower detection rate for smaller GGN exhibits no clear advantage for pure GGN, but has a higher detection rate for larger GGN. In conclusion, to a certain extent, PET‑CT makes up for the shortcomings of traditional imaging and has some clinical value for the diagnosis of GGN.
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1 

Gao YJ and Zsolt Szabo: Metabolic and anatomic characteristics of bronchioloalveolar carcinoma on 18F-FDG PET/CT. Chin J Nucl Med. 29:238–241. 2009.

2 

Naidich DP, Bankier AA, MacMahon H, Schaefer-Prokop CM, Pistolesi M, Goo JM, Macchiarini P, Crapo JD, Herold CJ, Austin JH and Travis WD: Recommendations for the management of subsolid pulmonary nodules detected at CT: A statement from the fleishchner society. Radiology. 266:304–317. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Kim H, Park CM, Koh JM, Lee SM and Goo JM: Pulmonary subsolid nodules: What radiologists need to know about the imaging features and management strategy. Diagn Interv Radiol. 20:47–57. 2014.PubMed/NCBI

4 

Park CM, Goo JM, Lee HJ, Lee CH, Chun EJ and Im JG: Nodular Ground-glass opacity at thin-section CT: Histologic correlation and evaluation of change at follow up. Radiographics. 27:391–408. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Eglinton T, Luck A, Bartholomeusz D, Varghese R and Lawrence M: Positron-emission tomography/computed tomography (PET/CT) in the initial staging of primary rectal cancer. Colorectal Dis. 12:667–673. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Jung W, Jang JY, Kang MJ, Chang YR, Shin YC, Chang J and Kim SW: The clinical usefulness of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in follow-up of curatively resected pancreatic cancer patients. HPB (Oxford). 18:57–64. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Mac Manus MP and Hicks RJ: PET scanning in lung cancer: Current status and future directions. Semin Surg Oneol. 21:149–155. 2003. View Article : Google Scholar

8 

Liu W, Li X, Quan J, Ouyang X and Zheng H: Diagnostic value of 18F-FDG PET/CT for solitary nodular-type bronchoalveolar carcinoma. Nan Fang Yi Ke Da Xue Xue Bao. 33:114–116. 2013.(In Chinese). PubMed/NCBI

9 

Dalli A, Sen H Selimoglu, Coskunsel M, Komek H, Abakay O, Sergi C and Tanrikulu A Cetin: Diagnostic value of PET/CT in differentiating benign from malignant solitary pulmonary nodules. J BUON. 18:935–941. 2013.PubMed/NCBI

10 

Christensen JA, Nathan MA, Mullan BP, Hartman TE, Swensen SJ and Lowe VJ: Characterization of the solitary pulmonary nodule: 18F FDG PET versus nodule-enhancement CT. AJR Am J Roentgenol. 187:1361–1367. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Collins J and Stern EJ: Ground-glass opacity at CT: The ABCs. AJR Am J Roentgenol. 169:355–367. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Kandemir Z, Sentürk A, Ozdemir E, Yildirim N, Hasanoğlu HC, Keskin M and Türkölmez S: The evaluation of hypermetabolic mediastinal-hilar lymph nodes determined by PET/CT in pulmonary and extrapulmonary malignancies: Correlation with EBUS-TBNA. Turk J Med Sci. 45:1234–1242. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Park CM, Goo JM, Lee HJ, Lee CH, Chun EJ and Im JG: Nodular ground-glass opacity at thin-section CT: Histologic correlation and evaluation of change at follow-up. Radiographics. 27:391–408. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Lei Z, Xu N, Zhang J, et al: MSCT diagnosis of unusual interstitial pneumonia. Chin J Mod Med. 22:76–79. 2012.

15 

Qi YG, Huang Y, Zheng JS, et al: The Features and diagnostic value of CT and PET in pneumonia type of bronchioloalveolar carcinoma. J Clin Radic. 29:187–190. 2010.

16 

Guo G, Chen N, Li GF, et al: Complete video-assisted thoracoscopic surgery for the diagnosis and treatment of focal ground-glass opacity. Chin J Min Inv Surg. 12:641–643. 2012.

17 

Jiang BG and Li L: Characteristics of thin slice spiral CT imaging in 45 cases of solitary pulmonary nodule. Chin J Geront. 31:1541–1543. 2011.

18 

Porcu P: A look at the national comprehensive cancer network guidelines for cutaneous lymphomas. Clin Lymphoma Myeloma Leuk. 10 Suppl 2:S109–S111. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Lin CC, Chen LC, Tseng VS, Yan JJ, Lai WW, Su WP, Lin CH, Huang CY and Su WC: Malignant pleural effusion cells show aberrant glucose metabolism gene expression. Eur Respir J. 37:1453–1465. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Erasmus JJ, McAdams HP, Rossi SE, Goodman PC, Coleman RE and Patz EF: FDG PET of pleural effusions in patients with non-small cell lung cancer. AJR Am J Roentgenol. 175:245–249. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Endo K, Oriuchi N, Higuchi T, Iida Y, Hanaoka H, Miyakubo M, Ishikita T and Koyama K: PET and PET/CT using 18 F-FDG in the diagnosis and management of cancer patients. Int J Clin Oncol. 11:286–296. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Glaudemans AW, de Vries EF, Galli F, Dierckx RA, Slart RH and Signore A: The use of (18)F-FDG-PET/CT for diagnosis and treatment monitoring of inflammatory and infectious diseases. Clin Dev Immunol. 2013:6230362013. View Article : Google Scholar : PubMed/NCBI

23 

Mi B, Wan W, Yu C, You X, Jiang F and You Q: The value of extra-lung lesions on ¹8F-FDG PET/CT in improving diagnosis of lung cancer. Zhongguo Fei Ai Za Zhi. 15:78–83. 2012.(In Chinese). PubMed/NCBI

24 

Birim O, Kappetein AP, Stijnen T and Bogers AJ: Meta-analysis of positron emission tomographic and computed tomographic imaging in detecting mediastinal lymph node metastases in nonsmall cell lung cancer. Ann Thorac Surg. 79:375–382. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Waki A, Fujibayashi Y, Yonekura Y, Sadato N, Ishii Y and Yokoyama A: Reassessment of FDG uptake in tumor cells: High FDG uptake as a reflection of oxygen-independent glycolysis dominant energy production. Nucl Med Biol. 24:665–670. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Macheda ML, Rogers S and Best JD: Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol. 202:654–662. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Arabi M and Piert M: Hypoxia PET/CT imaging: Implications for radiation oncology. Q J Nucl Mol Imaging. 54:500–509. 2010.

28 

Chan WK, Au WY, Wong CY, Liang R, Leung AY, Kwong YL and Khong PL: Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B- and T-cell lymphomas. Clin Nucl Med. 35:571–575. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Koiso K, Kakizoe T, Murahashi I, Umeda T and Ueno A: Studies on the metabolic activities of the bladder tumors. 2. Studies on the energy metabolism of the bladder tumors (author's transl). Nihon Hinyokika Gakkai Zasshi. 68:22–32. 1977.(In Japanese).

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Copy and paste a formatted citation
Spandidos Publications style
Hu L, Pan Y, Zhou Z and Gao J: Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules. Exp Ther Med 14: 5109-5113, 2017.
APA
Hu, L., Pan, Y., Zhou, Z., & Gao, J. (2017). Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules. Experimental and Therapeutic Medicine, 14, 5109-5113. https://doi.org/10.3892/etm.2017.5194
MLA
Hu, L., Pan, Y., Zhou, Z., Gao, J."Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules". Experimental and Therapeutic Medicine 14.5 (2017): 5109-5113.
Chicago
Hu, L., Pan, Y., Zhou, Z., Gao, J."Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5109-5113. https://doi.org/10.3892/etm.2017.5194
Copy and paste a formatted citation
x
Spandidos Publications style
Hu L, Pan Y, Zhou Z and Gao J: Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules. Exp Ther Med 14: 5109-5113, 2017.
APA
Hu, L., Pan, Y., Zhou, Z., & Gao, J. (2017). Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules. Experimental and Therapeutic Medicine, 14, 5109-5113. https://doi.org/10.3892/etm.2017.5194
MLA
Hu, L., Pan, Y., Zhou, Z., Gao, J."Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules". Experimental and Therapeutic Medicine 14.5 (2017): 5109-5113.
Chicago
Hu, L., Pan, Y., Zhou, Z., Gao, J."Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5109-5113. https://doi.org/10.3892/etm.2017.5194
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