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Article

MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway

  • Authors:
    • Hongling Hu
    • Yu Ding
    • Yang Wang
    • Shuang Geng
    • Jue Liu
    • Jinrong He
    • Yang Lu
    • Xueying Li
    • Mingli Yuan
    • Shan Zhu
    • Su Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China, Key Laboratory for Molecular Diagnosis of Hubei, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China, Department of Clinical Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China
  • Pages: 6105-6112
    |
    Published online on: October 17, 2017
       https://doi.org/10.3892/etm.2017.5322
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Abstract

Previous results have indicated that mitochondrial ATP‑sensitive potassium (mitoKATP) channels are associated with the hypoxic proliferation of pulmonary artery smooth muscle cells (PASMCs). However, the mechanism underlying the promotive effects of mitoKATP channels on cell proliferation in response to hypoxia remains unknown. mitoKATP channel opening results in a collapse of mitochondrial membrane potential and generation of mitochondrial reactive oxygen species (ROS). As hypoxia‑inducible factor‑1α (HIF‑1α) is a critical oxygen sensor and major transcriptional regulator of the hypoxic adaptive response, the current study assessed whether mitoKATP opening contributes to the chronic proliferation of human PASMCs (hPASMCs) in collaboration with HIF‑1α and its downstream targets under hypoxic conditions. The present study demonstrated that there was crosstalk between mitoKATP channels and HIF‑1α signaling in PASMCs under hypoxic conditions. The results suggest that mitoKATP channels are involved in the proliferation of PASMCs during hypoxia through upregulation of the ROS/HIF/microRNA‑210/iron‑sulfur cluster protein signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Hu H, Ding Y, Wang Y, Geng S, Liu J, He J, Lu Y, Li X, Yuan M, Zhu S, Zhu S, et al: MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway. Exp Ther Med 14: 6105-6112, 2017.
APA
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J. ... Zhao, S. (2017). MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway. Experimental and Therapeutic Medicine, 14, 6105-6112. https://doi.org/10.3892/etm.2017.5322
MLA
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J., Lu, Y., Li, X., Yuan, M., Zhu, S., Zhao, S."MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway". Experimental and Therapeutic Medicine 14.6 (2017): 6105-6112.
Chicago
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J., Lu, Y., Li, X., Yuan, M., Zhu, S., Zhao, S."MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6105-6112. https://doi.org/10.3892/etm.2017.5322
Copy and paste a formatted citation
x
Spandidos Publications style
Hu H, Ding Y, Wang Y, Geng S, Liu J, He J, Lu Y, Li X, Yuan M, Zhu S, Zhu S, et al: MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway. Exp Ther Med 14: 6105-6112, 2017.
APA
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J. ... Zhao, S. (2017). MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway. Experimental and Therapeutic Medicine, 14, 6105-6112. https://doi.org/10.3892/etm.2017.5322
MLA
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J., Lu, Y., Li, X., Yuan, M., Zhu, S., Zhao, S."MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway". Experimental and Therapeutic Medicine 14.6 (2017): 6105-6112.
Chicago
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J., Lu, Y., Li, X., Yuan, M., Zhu, S., Zhao, S."MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6105-6112. https://doi.org/10.3892/etm.2017.5322
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