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Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis

  • Authors:
    • Liu Hong
    • Yu Shanjiang
    • Wang Qian
    • Li Chunguo
    • Zhou Fei
    • Yu Jinming
    • Gao Jiyou
    • Li Na
    • Li Yang
    • Du Feng
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, People's Hospital of Linzi, Zibo, Shandong 255400, P.R. China, Department of Orthopedics, Shandong Provincial Hospital, Jinan, Shandong 250021, P.R. China, Department of Orthopedics, Central Hospital of Zibo Mining Group, Zibo, Shandong 255120, P.R. China
    Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5990-5996
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    Published online on: October 18, 2017
       https://doi.org/10.3892/etm.2017.5326
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Abstract

Cylindromatosis (CYLD) is a deubiquitinating enzyme that regulates multiple key signaling pathways involved in the pathophysiology of knee osteoarthritis (KOA). Previous studies have indicated that the expression of CYLD in the articular cartilage of patients with KOA is significantly higher than in healthy controls. However, limited data are available regarding the association between CYLD expression and the severity of KOA. The aim of the present study was to investigate the association between CYLD expression in joint tissues and the severity of KOA. A total of 156 individual tibial plateau samples were obtained between January 2011 and January 2016 from patients that had undergone total knee arthroplasty due to KOA or from healthy controls. The severity of KOA was evaluated using the Kellgren Lawrence (KL) and Mankin scoring systems. Additionally, CYLD expression in the articular cartilage and subchondral bone was analyzed using immunohistochemistry. Compared with the healthy controls, patients with KOA exhibited significantly increased CYLD levels in the articular cartilage (6.53±2.01 vs. 28.69±13.23, P<0.001) and significantly decreased CYLD levels in the subchondral bone (11.46±2.34 vs. 3.50±2.54, P<0.001). Correlation analysis indicated that CYLD expression in the articular cartilage was positively correlated with the KL (r=0.837, P<0.001) and Mankin scores (r=0.925, P<0.001), while its expression in the subchondral bone was negatively correlated with the KL (r=‑0.802, P<0.001) and Mankin scores (r=‑0.844, P<0.001). The results of the present study demonstrate that CYLD levels in the articular cartilage and subchondral bone are associated with the severity of KOA. Thus, CYLD may be a potential diagnostic and predictive biomarker for KOA and a novel target in its treatment.
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1 

Heidari B: Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I. Caspian J Intern Med. 2:205–212. 2011.PubMed/NCBI

2 

Man GS and Mologhianu G: Osteoarthritis pathogenesis-a complex process that involves the entire joint. J Med Life. 7:37–41. 2014.PubMed/NCBI

3 

Hayami T: Osteoarthritis of the knee joint as a cause of musculoskeletal ambulation disability symptom complex (MADS). Clin Calcium. 18:1574–1580. 2008.(In Japanese). PubMed/NCBI

4 

Guilak F: Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol. 25:815–823. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Powell A, Teichtahl AJ, Wluka AE and Cicuttini FM: Obesity: A preventable risk factor for large joint osteoarthritis which may act through biomechanical factors. Br J Sports Med. 39:4–5. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Mitomi H, Mori T, Juji T, Katsuragawa Y, Yamamoto S, et al: Regional differences in chondrocyte metabolism in osteoarthritis: A detailed analysis by laser capture microdissection. Arthritis Rheum. 58:154–163. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Hunter DJ, Nevitt M, Losina E and Kraus V: Biomarkers for osteoarthritis: Current position and steps towards further validation. Best Pract Res Clin Rheumatol. 28:61–71. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Attur M, Krasnokutsky-Samuels S, Samuels J and Abramson SB: Prognostic biomarkers in osteoarthritis. Curr Opin Rheumatol. 25:136–144. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Gao SG, Zeng C, Liu JJ, Tian J, Cheng C, Zhang FJ, Xiong YL, Pan D, Xiao YB and Lei GH: Association between Wnt inhibitory factor-1 expression levels in articular cartilage and the disease severity of patients with osteoarthritis of the knee. Exp Ther Med. 11:1405–1409. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Qing L, Lei P, Liu H, Xie J, Wang L, Wen T and Hu Y: Expression of hypoxia-inducible factor-1α in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis. Exp Ther Med. 13:63–68. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Al-Jarallah KF, Shehab D, Al-Awadhi A, Nahar I, Haider MZ and Moussa MA: Are 25(OH)D levels related to the severity of knee osteoarthritis and function? Med Princ Pract. 21:74–78. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Li Y, Xiao W, Sun M, Deng Z, Zeng C, Li H, Yang T, Li L, Luo W and Lei G: The expression of osteopontin and Wnt5a in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity. Biomed Res Int. 2016:95610582016.PubMed/NCBI

13 

Fang J, Xu L, Li Y and Zhao Z: Roles of TGF-beta 1 signaling in the development of osteoarthritis. Histol Histopathol. 31:1161–1167. 2016.PubMed/NCBI

14 

Rigoglou S and Papavassiliou AG: The NF-κB signalling pathway in osteoarthritis. Int J Biochem Cell Biol. 45:2580–2584. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Zeng GQ, Chen AB, Li W, Song JH and Gao CY: High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis. Genet Mol Res. 14:14811–14822. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J and Sun SC: Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest. 118:1858–1866. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, et al: CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt. Nat Commun. 3:7712012. View Article : Google Scholar : PubMed/NCBI

18 

Song J, Jin EH, Kim D, Kim KY, Chun CH and Jin EJ: MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis. BBA Clin. 3:79–89. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, et al: 2010 rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62:2569–2581. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Edwards MH, Parsons C, Bruyère O, Dop Petit F, Chapurlat R, Roemer FW, Guermazi A, Zaim S, Genant H, Reginster JY, et al: High kellgren-lawrence grade and bone marrow lesions predict worsening rates of radiographic joint space narrowing; the SEKOIA study. J Rheumatol. 43:657–665. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Jaiprakash A, Prasadam I, Feng JQ, Liu Y, Crawford R and Xiao Y: Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: A possible pathological role in subchondral bone sclerosis. Int J Biol Sci. 8:406–417. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Wei F, Zhou J, Wei X, Zhang J, Fleming BC, Terek R, Pei M, Chen Q, Liu T and Wei L: Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage. Osteoarthritis Cartilage. 20:755–763. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Welte S, Urbanik T, Elßner C, Kautz N, Koehler BC, Waldburger N, Bermejo JL, Pinna F, Weiss KH, Schemmer P, et al: Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma. PLoS One. 9:e1105912014. View Article : Google Scholar : PubMed/NCBI

24 

Burr DB and Gallant MA: Bone remodelling in osteoarthritis. Nat Rev Rheumatol. 8:665–673. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Anderson-MacKenzie JM, Quasnichka HL, Starr RL, Lewis EJ, Billingham ME and Bailey AJ: Fundamental subchondral bone changes in spontaneous knee osteoarthritis. Int J Biochem Cell Biol. 37:224–236. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA and Duong LT: Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone. 38:234–243. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Day JS, Ding M, van der Linden JC, Hvid I, Sumner DR and Weinans H: A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res. 19:914–918. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Zhang LZ, Zheng HA, Jiang Y, Tu YH, Jiang PH and Yang AL: Mechanical and biologic link between cartilage and subchondral bone in osteoarthritis. Arthritis Care Res (Hoboken). 64:960–967. 2012.PubMed/NCBI

29 

Sharma AR, Jagga S, Lee SS and Nam JS: Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis. Int J Mol Sci. 14:19805–19830. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Yuan XL, Meng HY, Wang YC, Peng J, Guo QY, Wang AY and Lu SB: Bone-cartilage interface crosstalk in osteoarthritis: Potential pathways and future therapeutic strategies. Osteoarthritis Cartilage. 22:1077–1089. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Findlay DM and Kuliwaba JS: Bone-cartilage crosstalk: A conversation for understanding osteoarthritis. Bone Res. 4:160282016. View Article : Google Scholar : PubMed/NCBI

32 

Shen J, Li S and Chen D: TGF-β signaling and the development of osteoarthritis. Bone Res. 2:pii: 14002. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Van der Kraan PM: Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis. Biomed Mater Eng. 24 1 Suppl:S75–S80. 2014.

34 

Jenkins ZA, van Kogelenberg M, Morgan T, Jeffs A, Fukuzawa R, Pearl E, Thaller C, Hing AV, Porteous ME, Garcia-Miñaur S, et al: Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nat Genet. 41:95–100. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H and Maurice MM: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell. 37:607–619. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Li X, Huang J and Zhang H: An analysis and of hospital preparedness capacity for public health emergency in four regions of China: Beijing, Shandong Guangxi and Hainan. BMC Public Health. 8:3192008. View Article : Google Scholar : PubMed/NCBI

37 

Guermazi A, Hayashi D, Roemer F, Felson DT, Wang K, Lynch J, Amin S, Torner J, Lewis CE and Nevitt MC: Severe radiographic knee osteoarthritis-does Kellgren and Lawrence grade 4 represent end stage disease?-the MOST study. Osteoarthritis Cartilage. 23:1499–1505. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Schiphof D, Boers M and Bierma-Zeinstra SM: Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis. Ann Rheum Dis. 67:1034–1036. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hong L, Shanjiang Y, Qian W, Chunguo L, Fei Z, Jinming Y, Jiyou G, Na L, Yang L, Feng D, Feng D, et al: Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis. Exp Ther Med 14: 5990-5996, 2017.
APA
Hong, L., Shanjiang, Y., Qian, W., Chunguo, L., Fei, Z., Jinming, Y. ... Feng, D. (2017). Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis. Experimental and Therapeutic Medicine, 14, 5990-5996. https://doi.org/10.3892/etm.2017.5326
MLA
Hong, L., Shanjiang, Y., Qian, W., Chunguo, L., Fei, Z., Jinming, Y., Jiyou, G., Na, L., Yang, L., Feng, D."Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis". Experimental and Therapeutic Medicine 14.6 (2017): 5990-5996.
Chicago
Hong, L., Shanjiang, Y., Qian, W., Chunguo, L., Fei, Z., Jinming, Y., Jiyou, G., Na, L., Yang, L., Feng, D."Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5990-5996. https://doi.org/10.3892/etm.2017.5326
Copy and paste a formatted citation
x
Spandidos Publications style
Hong L, Shanjiang Y, Qian W, Chunguo L, Fei Z, Jinming Y, Jiyou G, Na L, Yang L, Feng D, Feng D, et al: Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis. Exp Ther Med 14: 5990-5996, 2017.
APA
Hong, L., Shanjiang, Y., Qian, W., Chunguo, L., Fei, Z., Jinming, Y. ... Feng, D. (2017). Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis. Experimental and Therapeutic Medicine, 14, 5990-5996. https://doi.org/10.3892/etm.2017.5326
MLA
Hong, L., Shanjiang, Y., Qian, W., Chunguo, L., Fei, Z., Jinming, Y., Jiyou, G., Na, L., Yang, L., Feng, D."Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis". Experimental and Therapeutic Medicine 14.6 (2017): 5990-5996.
Chicago
Hong, L., Shanjiang, Y., Qian, W., Chunguo, L., Fei, Z., Jinming, Y., Jiyou, G., Na, L., Yang, L., Feng, D."Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5990-5996. https://doi.org/10.3892/etm.2017.5326
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